DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11696 and CG8388

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	179/654 - (27%)
Similarity:	287/654 - (43%)	Gaps:	129/654 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MICRLC---LEDAEHGVPIFGQE-PPMGQPAHRQLAELIERHLLLVLAENDVVSTCLCNRCWRQL 61
            |.|.||   ::||...:....:| ..:|      |..:||:|..|.:.::.... .:|..||.||
  Fly     1 MPCFLCTQTVDDAAGNIEFASEEADSLG------LRCIIEKHFWLQIPDSKRAG-YVCGPCWEQL 58

  Fly    62 AEIEQFCSMVAEKQRSLHRSLQLKTELPELPELTEPEPALVVWNTESPIEPKLSYEGDDIKDHIL 126
            .....|...|.:..::|.:::..:|..||:              ..|.:|           :||:
  Fly    59 LLFHNFYLNVEQAHKALEQTVLKETSPPEV--------------VASALE-----------EHIV 98

  Fly   127 CEPVIDALSAGDEKDSDYGDTFEPDFEPESQPDEEEEPEPDPVKPRPRGRPRKTALQQTHQIIKR 191
            .....|:::|.                               || |.||||||.|.|..
  Fly    99 KSEHDDSVAAA-------------------------------VK-RRRGRPRKVAQQDA------ 125

  Fly   192 KYEKRKQQNKAKITELSLRESRARQRELKRSSAGAEDDQDGDE-------DEEDEEDVGGELTPD 249
                 :::.|:.:.:::|.|.:....|...:.|...:||:..:       .:|..||      |:
  Fly   126 -----REELKSVLEQINLNEIKIEFPEADLTIADVLEDQEEQDFLPDDCISKEGAED------PE 179

  Fly   250 ADEQPKPRGKR---GRPKTKKLVTADDNDDTSEVPVKRSSIKEMDDYIAANVKLDCAICAAPLED 311
            ..|:..|..||   ||.:.::.|...:..:||.:| |....:|.:|||..:.|:.|.||..|:||
  Fly   180 VLEKKPPTLKRKVSGRSRGRRRVQLAERPNTSCLP-KIQKSQEFNDYIREHYKVQCHICNLPMED 243

  Fly   312 FNDLKRHFRVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVMHMLR 376
            |:::..|.|.||...||..|||.::.||.:.||||..|:||:.|.|..|.:...:|.|..:||..
  Fly   244 FSEMLAHVRREHKQRGYAMCCNRKFLKRGVLVDHLRRHQDPETFKCSICGRVMGHRRSLELHMRM 308

  Fly   377 FHSQQQELVHQCAICEARFAKKFLLTMHLKGHKGTERPEV-CDTCSKTFRTKFELSAHVKRMHAA 440
            ...:.:..:::|..|...|....:...|...|...|:.:| |..|.||:.:::.:..|||.:|..
  Fly   309 HEIKSRGRLYRCEQCSKAFYSAVVYERHKLTHIPREQWKVPCTHCEKTYPSQYTMQQHVKLVHLN 373

  Fly   441 DFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDRDGDT 505
            .:.. |||:||...|.:.....|.:. |..||.|.::|.||...|..:..|.:|:......:...
  Fly   374 LYAK-ICDVCGKSIRGREALARHMEE-HTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQ 436

  Fly   506 KYRCLLCNAEKSSRAALSSHMRY-HHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLYQCQFCT 569
            ..:|..|.....|..|...|::| |::|:.|:|.:|:|.||.|..|.|||.||||..||.|..|.
  Fly   437 PMQCEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTTHTGEVLYTCPHCP 501

  Fly   570 RTFKSHANMHNHKKKMHPNDW---------------------VRKYSQ--------PSSSITSTA 605
            :||.|:||||.|:||:|..:|                     |||.::        |:.:|.:|:
  Fly   502 QTFNSNANMHAHRKKVHRKEWEENRHKRLNRSRKSDTIIAVSVRKTTETRQDGGLVPAEAIATTS 566

  Fly   606 APLA 609
            :|.|
  Fly   567 SPRA 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	19/79 (24%)
		C2H2 Zn finger	332..349	CDD:275368	8/16 (50%)
		C2H2 Zn finger	357..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	4/19 (21%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	6/17 (35%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	6/20 (30%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..583	CDD:275368	10/17 (59%)
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	15/62 (24%)
		C2H2 Zn finger	264..281	CDD:275368	8/16 (50%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..369	CDD:275368	6/18 (33%)
		C2H2 Zn finger	440..461	CDD:275368	6/20 (30%)
		C2H2 Zn finger	469..489	CDD:275368	10/19 (53%)
		C2H2 Zn finger	497..515	CDD:275368	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10496
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.910