DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11696 and CG17568

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_609951.2	Gene:	CG17568 / 35198	FlyBaseID:	FBgn0032763	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	603	Identity:	140/603 - (23%)
Similarity:	224/603 - (37%)	Gaps:	151/603 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CRLCLEDAEHG-VPIFGQEPPMGQPAHRQLAELIERHLLLVLAENDVVSTCLCNRCWRQLAEIEQ 66
            ||||.:|..|| |.:...|...|. ....|...|.::..:.:...|.:|:.||..|:..::|:..
  Fly    11 CRLCAKDDAHGNVKVQMNENSQGN-WDNVLIMAIRKYFEVQMQLEDELSSVLCTECYTLISELID 74

  Fly    67 FCSMVAEKQRSLHRSLQLKTELPELPELTEPEPALVVWNTESPIEPKLSYEG--DDIKDHILCEP 129
            |...|.:.|           ::.|:...||.:     .:.|..:.......|  ||...||: :|
  Fly    75 FAEHVTKVQ-----------DIFEVLRRTETD-----GDQEMDVAALRQQFGLCDDDWTHII-KP 122

  Fly   130 VIDALSAGDEKDSDYGDTFE--PDF---EPESQPDEEEEPEPDPVKPRPRGRPRKTALQQTHQII 189
             |.||..  |.|:.|....|  .||   |..||..|..:            |...|.|.||.:.:
  Fly   123 -IPALEM--ESDNVYQKPAELLKDFPLAETSSQEMEISK------------RTTTTHLIQTKKNV 172

  Fly   190 KRKYEKRKQQNKAKITELSLRESRARQRELKRSSAGAEDDQDGDEDEEDEEDVGGELTPDADEQP 254
            :.:..|::..:...|    |.|....|.                    |.|||..||..:...||
  Fly   173 EMEIPKQEFIDLGPI----LLEKNTSQL--------------------DMEDVLDELPQEELSQP 213

  Fly   255 K------PRGKRGRPKTKKLVTADDNDDTSEVPVKRSSIKEMDDYIAANVKLDCAICAAP--LED 311
            :      |.......|::.|.:.:.:||.  :||.    .::.|.:        |:...|  ||.
  Fly   214 RLDSTTSPASMENDVKSEMLDSCEGDDDF--LPVD----GQLMDLV--------AVATTPNTLES 264

  Fly   312 FNDLKRHFRVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVMHMLR 376
            ..:.|.. |...||    :.|...|:.|..|..||.          :.||:  :.|..:|
  Fly   265 TAEEKAK-RGRMDC----EKCGKVYRNRASYEKHLE----------RECRR--IERRVKV----- 307

  Fly   377 FHSQQQELVHQCAICEARFAKKFLLTMHLKGHKGTERPEVCDTCSKTFRTKFELSAHVKRMHAAD 441
                 .:....|.||....:....|.:|.:|.....:|.:||:|.|..:|...|:.| |.:| .:
  Fly   308 -----DKTTTTCDICNKTLSSATALKLHKEGIHQNVKPYICDSCGKQLKTITALNEH-KLVH-TE 365

  Fly   442 FTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDRDGDTK 506
            ..|..|.:|...|:::|....|.: :|.:   ....|.:||:.|:..|:...|...|.:.
  Fly   366 SRPFECTVCKAGFKNRARLKAHYQ-IHAE---PSFVCNICGKKLQTRRTWNMHKVVHTEE----- 421

  Fly   507 YRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLYQCQFCTRT 571
                                      :|.||.:|...||..:.|..|:.:|||:..|.|.:|.::
  Fly   422 --------------------------RRLKCDVCGALFKRSKTLKTHLLSHTGLRPYVCNYCGKS 460

  Fly   572 FKSHANMHNHKKKMHPND 589
            |..:||..:||.|.||.:
  Fly   461 FACNANCRSHKLKKHPQE 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	21/75 (28%)
		C2H2 Zn finger	332..349	CDD:275368	6/16 (38%)
		C2H2 Zn finger	357..378	CDD:275368	4/20 (20%)
		C2H2 Zn finger	388..408	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	447..465	CDD:275368	5/17 (29%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	0/19 (0%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..583	CDD:275368	6/17 (35%)
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871	21/87 (24%)
		COG5048	<313..471	CDD:227381	47/194 (24%)
		C2H2 Zn finger	314..335	CDD:275368	6/20 (30%)
		C2H2 Zn finger	343..363	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..391	CDD:275368	5/20 (25%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..463	CDD:290200	9/23 (39%)
		C2H2 Zn finger	454..475	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010