DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11696 and CG2889

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	665	Identity:	179/665 - (26%)
Similarity:	285/665 - (42%)	Gaps:	133/665 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MICRLCLEDAEHGVPIFGQEPPMGQPAHRQLAELIERHLLLVLAENDVVSTCLCNRCWRQLAEIE 65
            |||||||.....|..:|..|.. ...|..:|.::|.:.|.|.:..:|.:||.:|..|...|.:..
  Fly     1 MICRLCLRCLSPGSAVFLFETD-DTLAETRLVKMIAKFLQLEILPDDGISTSVCTECCEHLEDFN 64

  Fly    66 QFCSMVAEKQRSLHR----------------SLQLKTELPELPELTEPEPALVVWN-TESPIE-P 112
            .|..:|.:||.||.:                .:.:...:.|||        |...: .|.|:: .
  Fly    65 GFWQLVEQKQCSLKKEFLTVDVDCAAMKWTGGVDVDVNIDELP--------LAAGDMDEKPLDLH 121

  Fly   113 KLSYEGDDIKDHI----LCEPVIDALSAGDEKDSDYGDTFEP-----DFEP---ESQPDEEEEPE 165
            .||..|..:..::    :.||:.:.|...:|:|.      :|     |.||   |.||:.|.:..
  Fly   122 NLSLLGSVLDVNVDSVEVREPIKEQLPCEEEEDE------KPCLQASDSEPEVTEGQPESESDSS 180

  Fly   166 PDP--VKPRPRGRPRKTALQQTHQIIKRKYEKRKQQNKAKITELSLRESRARQREL--------K 220
            .|.  |:.:.:.:|            |||...|..:::..|         :.|:||        |
  Fly   181 DDEPLVRLKSKMKP------------KRKTSARSSKDQGPI---------SLQQELADLLDDGGK 224

  Fly   221 RSSAGAEDDQDGDEDEEDEEDVGGELTPDADEQPKPRGKRGRPKTKKLVTADDNDDTSEVPVKRS 285
            |....|.|.:...|.:|.|        ..|..:.||:|                  .|...:.:|
  Fly   225 RRRRKAPDQRTTTESQESE--------LQAVLERKPKG------------------CSRAQLAKS 263

  Fly   286 SIKEMDDYIAANVKLDCAICAAPLEDFNDLKRHFRVEHDCTGYVKCCNNRYKKRTLYVDHLHCHK 350
            ..|.:..|::|:    |.:|.......::||.||...|....|:|||...:.:.:..:||:..|.
  Fly   264 YEKAIASYMSAS----CDLCEFSAPYLSELKTHFLEVHQREYYIKCCGKVFTRASKLMDHIRKHI 324

  Fly   351 DPQYFSCQSCRKNFLNRNSQVMHMLRFHSQQQE----LVHQCAICEARFAKKFLLTMHLKGHKGT 411
            :|:.|:|..|:|:..:::....|:...|::..:    |...|..||..|:.:..:..||..|...
  Fly   325 NPKLFTCTICKKSLNSQDYLATHIETVHNKVAQIGKVLKFPCPKCERTFSSERRMANHLAKHDTD 389

  Fly   412 ERPEVCDTCSKTFRTKFELSAHVKRMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVA-E 475
            :....|:.|.|:|.....|..|::.:| .|....:|||||..|:.|.:|..|  .|...|.|| .
  Fly   390 QLEHTCEICCKSFANVHRLRRHIQSIH-EDLHRHVCDICGKKFKFKPSFERH--LLEHQGVVAPA 451

  Fly   476 VQCTLCGRWLRDERSLRKHLARHDDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRH-KCSL 539
            |:|.:|..||::|.|||.|...||..|    ..|..|....:||.||..|::|.|....: :|:.
  Fly   452 VECPICRVWLKNEHSLRLHRFTHDSTD----TVCPHCGKTCTSRTALRGHVKYAHKLTTNLQCTF 512

  Fly   540 CDKEFKLPRALAEHMATHTGIDLYQCQFCTRTFKSHANMHNHKKKMHPNDWVRKYSQPSSSITST 604
            |:|.||..|.|.||||.|||:.||.|..|.:..:|.:||:.|.|:.|.::|:|
  Fly   513 CEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHADEWLR------------ 565

  Fly   605 AAPLAHPNHPN-QPA 618
             |.:|..::|. :||
  Fly   566 -AKMARSHNPQFKPA 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	24/75 (32%)
		C2H2 Zn finger	332..349	CDD:275368	3/16 (19%)
		C2H2 Zn finger	357..378	CDD:275368	4/20 (20%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	447..465	CDD:275368	9/17 (53%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	11/19 (58%)
		C2H2 Zn finger	565..583	CDD:275368	6/17 (35%)
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	26/77 (34%)
		C2H2 Zn finger	276..297	CDD:275368	6/20 (30%)
		C2H2 Zn finger	306..323	CDD:275368	3/16 (19%)
		C2H2 Zn finger	331..352	CDD:275368	4/20 (20%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..416	CDD:275368	6/20 (30%)
		C2H2 Zn finger	424..444	CDD:275368	10/21 (48%)
		C2H2 Zn finger	481..502	CDD:275368	8/20 (40%)
		C2H2 Zn finger	510..530	CDD:275368	11/19 (58%)
		C2H2 Zn finger	538..556	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910