DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11696 and Zfp710

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001128035.1	Gene:	Zfp710 / 293044	RGDID:	1306491	Length:	687	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	146/634 - (23%)
Similarity:	222/634 - (35%)	Gaps:	193/634 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 DTFEPDFEPE--------------------------SQPDEEEEPEPDPV---KPRPRGRPRKTA 181
            :.|.||..||                          .:|.|||..|.:..   ..|.:.||
  Rat    64 EAFYPDLGPELSGTAMGEPGPPGPDIYQLACNGQALEEPPEEEVLEVEAAFEKHTRRKTRP---- 124

  Fly   182 LQQTHQIIKRKYEKRKQQNKAKITELSLRESRARQRELKRSSAGAEDDQDGDEDEEDEEDVGG-- 244
              ....:.|.|:||.:.:.:.::.|:|:                ..||:|....|..||...|
  Rat   125 --PVRLVPKVKFEKAEDEEEQEVYEVSV----------------PGDDKDPGPAEAPEEAASGGC 171

  Fly   245 ---------ELTPDADEQPKPRGKRGRPKTKK--LVTADDNDDTSEVPVKRSSIKEMDDYIAANV 298
                     ::...:....|||..|..|:|.:  |.|| ..|.....|.:       |.::..::
  Rat   172 EALVQSSAVKMIDLSAFSRKPRTLRHLPRTPRPELDTA-PFDPPFPDPAR-------DGFLEPSM 228

  Fly   299 KL--------DCAI---CAAPLED-------FNDL---------KRHFRVEHDCTGYVKCCNNRY 336
            .|        :|:.   ..|||.:       ..:|         :.....|.|..|...   .|:
  Rat   229 ALPGSETLPTECSFEPPHLAPLSNPEPPNMTSTELVKPEQGFVWQESSEFEADTAGSTV---ERH 290

  Fly   337 KKRTLYVDHLHCHKDPQY----------FSCQSCRKNFLNRNSQVMHMLRFHSQQQELVHQCAIC 391
            ||..|....::...|..|          :.|:.|.|::.::.:.|.|:|..:..:.   |.|..|
  Rat   291 KKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKP---HSCPHC 352

  Fly   392 EARFAKKFLLTMHLKGHKGTERPEVCDTCSKTFRTKFELSAHVKR---MHAADFTPIICDICGTH 453
            ...|.:...|..||..|:|| ||..|..|.|.|..    ::|:||   :| ::..|..|..||..
  Rat   353 SKLFKQPSHLQTHLLTHQGT-RPHKCQVCHKAFTQ----TSHLKRHMLLH-SEVKPYSCHFCGRG 411

  Fly   454 FRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDRDGDTKYRCLLCNAEKSS 518
            |...:....| :..|..|...  .|..||........|::|||.|   .|.|.|:||.|:.....
  Rat   412 FAYPSELKAH-EVKHESGRCH--VCVECGLDFSTLTQLKRHLASH---QGPTLYQCLECDKSFHY 470

  Fly   519 RAALSSHMRYH------------------HSAKRH----------KCSLCDKEFKLPRALAEHMA 555
            |:.|.:||..|                  |..|:|          ||.:|.:||.|...:..||.
  Rat   471 RSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHML 535

  Fly   556 THTGIDLYQCQFCTRTF------KSHANMHN----HKKKMHPNDWVRKYSQPSSSITSTAAPLAH 610
            .||.:..|||..|.:||      |:|..:|:    .|.|:....:.|.|:.           |.|
  Rat   536 IHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNL-----------LGH 589

  Fly   611 PNHPNQPAPPAAAP---------TNLAGHMLPPLGGIAKSLIEIPDTEG 650
             .|.:..:.|...|         .||:.||....|.:..||    |::|
  Rat   590 -MHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDISL----DSQG 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	332..349	CDD:275368	4/16 (25%)
		C2H2 Zn finger	357..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/23 (30%)
		C2H2 Zn finger	447..465	CDD:275368	5/17 (29%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..583	CDD:275368	7/27 (26%)
Zfp710	NP_001128035.1	C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		COG5048	<359..617	CDD:227381	76/281 (27%)
		zf-H2C2_2	361..386	CDD:290200	12/25 (48%)
		C2H2 Zn finger	377..397	CDD:275368	7/23 (30%)
		zf-H2C2_2	389..414	CDD:290200	9/25 (36%)
		C2H2 Zn finger	405..425	CDD:275368	5/20 (25%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		zf-C2H2	459..481	CDD:278523	8/21 (38%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		zf-H2C2_2	474..498	CDD:290200	4/23 (17%)
		C2H2 Zn finger	489..509	CDD:275368	3/19 (16%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		zf-H2C2_2	529..554	CDD:290200	10/24 (42%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		zf-H2C2_2	558..582	CDD:290200	5/23 (22%)
		C2H2 Zn finger	573..593	CDD:275368	6/31 (19%)
		C2H2 Zn finger	601..620	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930