DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11696 and Zfp710

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001139471.1	Gene:	Zfp710 / 209225	MGIID:	1921747	Length:	666	Species:	Mus musculus

Alignment Length:	639	Identity:	149/639 - (23%)
Similarity:	219/639 - (34%)	Gaps:	183/639 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 PEL-PELT-----EPEPALVVWNTESPIEPKLSYEGDDI-----KDHILCEPVIDALSAGDEKDS 142
            |:| ||||     ||.|                 .|.||     ....|.||       .:|:..
Mouse    45 PDLGPELTGTAMGEPGP-----------------PGPDIYQLACNGRALEEP-------PEEEVL 85

  Fly   143 DYGDTFEPDFEPESQP-------------DEEEEPE-------PDPVKPRPRGRPRKTALQQTHQ 187
            :....||.....:::|             :||||.|       .|...|.|...|.:.|......
Mouse    86 EVEAAFEKHTRRKTRPPVRLVPKVKFEKAEEEEEQEVYEVSVPGDDKDPGPAEAPAEVASSGCEA 150

  Fly   188 IIKRKYEKRKQQNKAKITELSLRESRARQ-RELKRSSAGAEDDQDGDEDEEDEEDVGGELTPDAD 251
            ::        |.:..|:.:||....:.|. |.|.|:.....|....|....|         |..|
Mouse   151 LV--------QSSAVKMIDLSAFSRKPRTLRHLPRTPRPELDMAPFDPPFPD---------PARD 198

  Fly   252 EQPKPRGKRGRPKTKKLVTADDNDDTSEV----PVKRSSIKEMDDYIAANVKLDCAICAAPLEDF 312
            ..|:|......|:|.....:.:....:.:    |...:|..|:       ||.:.........:|
Mouse   199 GFPEPSMALPGPETLPTECSFEPPHLAPLSNPEPPNMTSTTEL-------VKPEQGFVWQESSEF 256

  Fly   313 NDLKRHFRVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQY----------FSCQSCRKNFLNR 367
                     |.|..|...   .|:||..|....::...|..|          :.|:.|.|::.::
Mouse   257 ---------EADTAGSTV---ERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSK 309

  Fly   368 NSQVMHMLRFHSQQQELVHQCAICEARFAKKFLLTMHLKGHKGTERPEVCDTCSKTFRTKFELSA 432
            .:.|.|:|..:..:.   |.|..|...|.:...|..||..|:|| ||..|..|.|.|..    ::
Mouse   310 YNLVTHILGHNGIKP---HSCPHCSKLFKQPSHLQTHLLTHQGT-RPHKCQVCHKAFTQ----TS 366

  Fly   433 HVKR---MHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKH 494
            |:||   :| ::..|..|..||..|...:....| :..|..|...  .|..||........|::|
Mouse   367 HLKRHMLLH-SEVKPYSCHFCGRGFAYPSELKAH-EVKHESGRCH--VCVECGLDFSTLTQLKRH 427

  Fly   495 LARHDDRDGDTKYRCLLCNAEKSSRAALSSHMRYH------------------HSAKRH------ 535
            ||.|   .|.|.|:||.|:.....|:.|.:||..|                  |..|:|
Mouse   428 LASH---QGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKG 489

  Fly   536 ----KCSLCDKEFKLPRALAEHMATHTGIDLYQCQFCTRTF------KSHANMHN----HKKKMH 586
                ||.:|.:||.|...:..||..||.:..|||..|.:||      |:|..:|:    .|.|:.
Mouse   490 VKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVC 554

  Fly   587 PNDWVRKYSQPSSSITSTAAPLAHPNHPNQPAPPAAAP---------TNLAGHM 631
            ...:.|.|:.           |.| .|.:..:.|...|         .||:.||
Mouse   555 GKSFNRMYNL-----------LGH-MHLHAGSKPFKCPYCSSKFNLKGNLSRHM 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	332..349	CDD:275368	4/16 (25%)
		C2H2 Zn finger	357..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/23 (30%)
		C2H2 Zn finger	447..465	CDD:275368	5/17 (29%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..583	CDD:275368	7/27 (26%)
Zfp710	NP_001139471.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..141		8/27 (30%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		zf-C2H2	325..347	CDD:333835	7/21 (33%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..364	CDD:372612	12/25 (48%)
		C2H2 Zn finger	355..375	CDD:275368	7/23 (30%)
		zf-H2C2_2	367..392	CDD:372612	9/25 (36%)
		C2H2 Zn finger	383..403	CDD:275368	5/20 (25%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		COG5048	<418..595	CDD:227381	49/191 (26%)
		C2H2 Zn finger	439..459	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..487	CDD:275368	3/19 (16%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		C2H2 Zn finger	523..543	CDD:275368	6/19 (32%)
		C2H2 Zn finger	551..571	CDD:275368	6/31 (19%)
		C2H2 Zn finger	579..598	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930