DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11696 and znf-782

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	636	Identity:	140/636 - (22%)
Similarity:	210/636 - (33%)	Gaps:	166/636 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 HRSLQLKTELPELPELTEPEPALVVWNTESPIEPKLSYEGDDIKDHILCEPVIDALSAGDEKD-- 141
            |:.....|.||:...:.:||        |...|   .||.:.:::....:..::.|...|...
Worm     6 HQPTTTNTTLPDDIHMKDPE--------EEEFE---EYEDELLEEEEEFDEELEELENSDSASSL 59

  Fly   142 ----SDYGDTFEPDFEPESQPDEEEEP-EPDPVKPRPRGRPRKTALQQTHQIIKRKYEKRKQQNK 201
                |.:|.:........|.|.:.:.| :.......|.|:|.|   :....:..:.:
Worm    60 VSAGSPHGSSSSNGSHGSSPPLQVQSPSQGSGSSGSPTGQPEK---RHICTVCGKGF-------- 113

  Fly   202 AKITELSLRESRARQRELKRSSAGAEDDQDGDEDEEDEEDVGGELTPDADEQPKPRGKRGRPKT- 265
               :..|:.||.      |||..|                            .||.......||
Worm   114 ---SYFSILESH------KRSHTG----------------------------EKPYNCHFCQKTF 141

  Fly   266 --KKLVTADDNDDTSEVPVKRSSIKEMDDYIAANVKLDCAICAAPLEDFNDLKRHFRVEHDCTGY 328
              |..:...:...|.|.|.|                  |..|......:.....|.:..|.....
Worm   142 AQKATLQVHERTHTGERPYK------------------CRYCEKTFAQYGTKTVHEKSAHLGIRN 188

  Fly   329 VKC--CNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVMHMLRFHSQQQELVHQCAIC 391
            .||  |:......:....|...|.| :.|.|..|.|.|..:|...:|:.:.| :|.|..|.|..|
Worm   189 YKCPKCDKLLSSPSALYTHKKTHGD-KTFRCDFCPKTFALKNYLKLHVKQVH-EQNERKHVCVYC 251

  Fly   392 EARFAKKFLLTMHLKGHKGTERPEVCDTCSKTFRTKFELSAHVKRMHAADFTPIICDICGTHFRS 456
            ...||....|.:|::.|.| |||.||..|.|.|.::..|.:| :|.|..: .|..|..|...|..
Worm   252 NKGFAYAGSLQVHVRTHTG-ERPYVCKFCPKAFASQGNLQSH-ERTHTGE-RPYSCQFCQRTFIQ 313

  Fly   457 KANFLIH-------KKALHPDGPVAEV----------------QCTLCGRWLRDERSLRKHLARH 498
            |:....|       |.:::||...|::                :||.|.:......||..|:.:|
Worm   314 KSQLTAHESTHLTQKHSVNPDSTTADILPVAGSVTDHQMVGNYECTFCNKKYPYASSLYIHMRKH 378

  Fly   499 DDRDGDTKYRCLLCNAEKSSRAALSSH----------MRYHHSAKRHKCSLCDKEFKLPRALAEH 553
            .::   :.|.|..|....|.:.:|:.|          ::...|...|.|..|.|.|....||..|
Worm   379 TEK---SAYSCDGCGKPYSQKISLNIHQDQCEAFKNRLKTTDSQFSHNCDGCGKSFVQRIALQIH 440

  Fly   554 MATHTGIDLYQCQFCTRTFKSHANMHNHKKKMHPNDWVRKYSQPSSSITST---AAPLAHPNHP- 614
            :.:        |:       .|.|:...|.....|.     :|.|.|.:.|   ..||  ||.|
Worm   441 VDS--------CE-------PHKNLARLKLSQQQNQ-----NQNSDSESDTEMKICPL--PNPPL 483

  Fly   615 -----NQPAPPAAAPTNLAGHMLP--PLGGIAKSLIEIPDTEGFDFGSNSS 658
                 :|..||   |.|:.....|  |||.|..:....|.|..|...|.||
Worm   484 TLAPTHQQIPP---PVNIYAQQPPPNPLGSILGNTSLTPQTLNFGLPSLSS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	332..349	CDD:275368	2/16 (13%)
		C2H2 Zn finger	357..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	5/24 (21%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	5/29 (17%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..583	CDD:275368	3/17 (18%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	5/36 (14%)
		zf-H2C2_2	119..143	CDD:290200	10/57 (18%)
		C2H2 Zn finger	134..154	CDD:275368	3/19 (16%)
		zf-H2C2_2	147..171	CDD:290200	6/41 (15%)
		C2H2 Zn finger	162..180	CDD:275368	3/17 (18%)
		COG5048	<187..404	CDD:227381	60/224 (27%)
		C2H2 Zn finger	191..211	CDD:275370	3/19 (16%)
		C2H2 Zn finger	218..239	CDD:275368	6/20 (30%)
		C2H2 Zn finger	248..268	CDD:275368	6/19 (32%)
		zf-H2C2_2	260..285	CDD:290200	12/25 (48%)
		C2H2 Zn finger	276..296	CDD:275368	7/20 (35%)
		zf-H2C2_2	288..313	CDD:290200	8/26 (31%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..403	CDD:275368	4/16 (25%)
		C2H2 Zn finger	424..441	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000