DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11696 and ZNF366

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_689838.1	Gene:	ZNF366 / 167465	HGNCID:	18316	Length:	744	Species:	Homo sapiens

Alignment Length:	624	Identity:	135/624 - (21%)
Similarity:	203/624 - (32%)	Gaps:	215/624 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDAEHGVP----IFGQEPPMGQPAHRQLAELIERHLLLVLAENDVVSTCLCNRCWRQLAEIEQFC 68
            |:..||:|    :|.|.|   :|.:.  :::|:                |||..::....:|.|.
Human   103 ENKNHGLPNLPLLFPQPP---RPKYD--SQMID----------------LCNVGFQFYRSLEHFG 146

  Fly    69 SMVAEKQRSLHRSLQLKTELPELPELTEPEPALVVW-NTESPIEPKLSYEGDDIKDHILCEPVID 132
            ....:::             |..|....|:|....: .|..|..||:
Human   147 GKPVKQE-------------PIKPSAVWPQPTPTPFLPTPYPYYPKV------------------ 180

  Fly   133 ALSAGDEKDSDYGDTFEPDFEPESQPDE-------EEEPEPDPVKPRPRGRPRKTALQQTHQIIK 190
                       :.....|.|.|.|.|..       .::| |:|:.|| :..|:::  ::|.|.::
Human   181 -----------HPGLMFPFFVPSSSPFPFSRHTFLPKQP-PEPLLPR-KAEPQES--EETKQKVE 230

  Fly   191 RKYEKRKQQNKAKITELSLRESRARQRELKRSSAGAEDDQDGDEDEEDEEDVGGELTPDADEQPK 255
            |.                                    |.:...|:....||||.
Human   231 RV------------------------------------DVNVQIDDSYYVDVGGS---------- 249

  Fly   256 PRGKRGR-PKTKKLVTADDNDDTSEVPVKRSSIKEMDDYIAANVKLDCAICAAPLEDFNDLKRHF 319
              .||.: |..:|..|:..|..|.  .:..|.||
Human   250 --QKRWQCPTCEKSYTSKYNLVTH--ILGHSGIK------------------------------- 279

  Fly   320 RVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVMHMLRFHSQQQEL 384
              .|.||.    |...:|:.:....|:..|:..:...||.|.|.|    :|..|:.|...|..|:
Human   280 --PHACTH----CGKLFKQLSHLHTHMLTHQGTRPHKCQVCHKAF----TQTSHLKRHMMQHSEV 334

  Fly   385 -VHQCAICEARFAKKFLLTMH------------------------LKGHKGTERPEV---CDTCS 421
             .|.|.:|...||....|..|                        ||.|..|.|..:   |..|.
Human   335 KPHNCRVCGRGFAYPSELKAHEAKHASGRENICVECGLDFPTLAQLKRHLTTHRGPIQYNCSECD 399

  Fly   422 KTFRTKFELSAHVKRMHAADFTPIICDICGTHF----RSKANFLIHKKALHPDGPVAEVQCTLCG 482
            |||:...:|..|:  |...|..|.||..||..|    ..|.:.|.||       .|.|.:|.:||
Human   400 KTFQYPSQLQNHM--MKHKDIRPYICSECGMEFVQPHHLKQHSLTHK-------GVKEHKCGICG 455

  Fly   483 RWLRDERSLRKHLARHDDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLP 547
            |......::::|:..|.:   ...|:|.||......:..|.:||..|...|..||.||.|||...
Human   456 REFTLLANMKRHVLIHTN---IRAYQCHLCYKSFVQKQTLKAHMIVHSDVKPFKCKLCGKEFNRM 517

  Fly   548 RALAEHMATHTGIDLYQCQFCTRTFKSHANMHNHKKKMH 586
            ..|..||..|:....::|.:|...|....|:..|.|..|
Human   518 HNLMGHMHLHSDSKPFKCLYCPSKFTLKGNLTRHMKVKH 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	14/73 (19%)
		C2H2 Zn finger	332..349	CDD:275368	3/16 (19%)
		C2H2 Zn finger	357..378	CDD:275368	8/20 (40%)
		C2H2 Zn finger	388..408	CDD:275368	8/43 (19%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	7/21 (33%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..583	CDD:275368	5/17 (29%)
ZNF366	NP_689838.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..228		7/25 (28%)
		COG5048	253..>549	CDD:227381	88/350 (25%)
		C2H2 Zn finger	255..275	CDD:275368	5/21 (24%)
		C2H2 Zn finger	283..303	CDD:275368	5/23 (22%)
		C2H2 Zn finger	311..331	CDD:275368	8/23 (35%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	367..387	CDD:275368	3/19 (16%)
		C2H2 Zn finger	395..415	CDD:275368	8/21 (38%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		Interaction with NRIP1. /evidence=ECO:0000269\|PubMed:17085477	455..744		31/105 (30%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	9/19 (47%)
		C2H2 Zn finger	535..554	CDD:275368	5/18 (28%)
		PXDLS. /evidence=ECO:0000269\|PubMed:16393996, ECO:0000269\|PubMed:17085477	590..594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930