DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11696 and E4f1

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001288713.1	Gene:	E4f1 / 13560	MGIID:	109530	Length:	783	Species:	Mus musculus

Alignment Length:	632	Identity:	128/632 - (20%)
Similarity:	199/632 - (31%)	Gaps:	248/632 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 LSLRESRARQRELKRSSAGAEDDQDG--------------------DEDEED------------- 238
            :::|.:.|...| .|:.||.|..:.|                    :|||:|
Mouse     5 MAVRVTAAHTAE-ARAEAGREAGEGGVAAAAALSSGGFLGLPAPFSEEDEDDVHRCGRCQVEFTA 68

  Fly   239 -EEDVGGEL--------------TPDA----DEQPKPRGKRG---RPKTKKLVTADDN---DDTS 278
             |:.|..::              ||.|    |::..|....|   .|.|...:..:..   :|.|
Mouse    69 LEDFVQHKIQKTCHRAPQEALPTTPAATALLDQEVVPTAAEGGPDEPITVAHIVVEATSLAEDIS 133

  Fly   279 EVP--VKRSSIKEM---------DDYIA-------------------ANVKL--------DCAIC 305
            ..|  |....|||:         |..:|                   |:|||        .|.:|
Mouse   134 HAPDLVGSGHIKEVIVAAEAEPGDVEMAEAPGSPNHQELGLLGEGEQAHVKLLVNKEGRYVCMLC 198

  Fly   306 AAPLEDFNDLKRHF-----RVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNF- 364
            ....:..:.||.|.     |.:|:|    |.|...::.:...:.|...|.|.:.:.|..|.|:|
Mouse   199 HKTFKTGSILKAHMVTHSSRKDHEC----KLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFR 259

  Fly   365 ----LNRN-------------------------------------------------SQVMHML- 375
                |.|:                                                 |.|:|::
Mouse   260 ESGALTRHLKSLTPCTEKIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLVT 324

  Fly   376 --------RFHSQQQEL-VHQCAI-----------CEARFAKKFLLTMHLK----------GHK- 409
                    ..|.|.||| :...|:           |.:..:::.||...::          |.:
Mouse   325 DAKGTVIHEVHVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIVLERVAGEES 389

  Fly   410 ---------------GTERPEV------------------------CDTCSKTFRTKFELSAHVK 435
                           |...||:                        |..||:||.|...|.|| |
Mouse   390 ALEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPTAATLEAH-K 453

  Fly   436 RMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAE--VQCTLCGRWLRDERSLRKHLARH 498
            |.|.|. .|..|..||..| .|| :|:.|   |.:..|.|  .:|..||:..:....:|.|...|
Mouse   454 RGHIAP-RPFTCTQCGKAF-PKA-YLLKK---HQEVHVHERRFRCGDCGKLYKTIAHVRGHRRVH 512

  Fly   499 DDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLY 563
            .|   :..:.|..|.....::.|...|.|.|...|.|.|..|.:.|:...:|..|:..|||...:
Mouse   513 SD---ERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVRHHTGEKPF 574

  Fly   564 QCQFCTRTFKSHANMHNHKKK-----MHPNDWVRKYSQPSSSITSTA 605
            :|..|.|.|..|..::.|.:.     :...:.:.....||::.|..|
Mouse   575 KCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLA 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	332..349	CDD:275368	2/16 (13%)
		C2H2 Zn finger	357..378	CDD:275368	9/83 (11%)
		C2H2 Zn finger	388..408	CDD:275368	4/40 (10%)
		C2H2 Zn finger	417..438	CDD:275368	11/20 (55%)
		C2H2 Zn finger	447..465	CDD:275368	7/17 (41%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..583	CDD:275368	6/17 (35%)
E4f1	NP_001288713.1	Required for ubiquitin ligase activity. /evidence=ECO:0000250	40..84		6/43 (14%)
		Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2. /evidence=ECO:0000250	185..264		18/82 (22%)
		COG5048	193..594	CDD:227381	89/414 (21%)
		C2H2 Zn finger	195..215	CDD:275368	5/19 (26%)
		zf-C2H2	221..243	CDD:278523	5/25 (20%)
		C2H2 Zn finger	223..243	CDD:275368	4/23 (17%)
		zf-H2C2_2	235..258	CDD:290200	6/22 (27%)
		C2H2 Zn finger	251..269	CDD:275368	6/17 (35%)
		Mediates interaction with CDKN2A. /evidence=ECO:0000250	368..565		50/206 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..407		2/20 (10%)
		Interaction with BMI1. /evidence=ECO:0000250	434..598		54/173 (31%)
		C2H2 Zn finger	436..456	CDD:275368	11/20 (55%)
		zf-C2H2	462..484	CDD:278523	9/26 (35%)
		C2H2 Zn finger	464..484	CDD:275368	9/24 (38%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		zf-H2C2_2	504..529	CDD:290200	6/27 (22%)
		Mediates interaction with TP53. /evidence=ECO:0000250	520..579		17/58 (29%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		zf-H2C2_2	534..555	CDD:290200	7/20 (35%)
		C2H2 Zn finger	548..568	CDD:275368	5/19 (26%)
		zf-H2C2_2	560..584	CDD:290200	8/23 (35%)
		Mediates interaction with RASSF1. /evidence=ECO:0000250	574..596		6/21 (29%)
		C2H2 Zn finger	576..595	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100