DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII215 and NRPD1A

DIOPT Version :9

Sequence 1:	NP_511124.1	Gene:	RpII215 / 32100	FlyBaseID:	FBgn0003277	Length:	1887	Species:	Drosophila melanogaster
Sequence 2:	NP_001185298.1	Gene:	NRPD1A / 842605	AraportID:	AT1G63020	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1690	Identity:	348/1690 - (20%)
Similarity:	589/1690 - (34%)	Gaps:	546/1690 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KAPLRQVKRVQFGILSPDEIRRMSVTEGGVQFAETMEGGRPKLGGLMDPRQGVIDRTSRCQTCAG 72
            :.|:..:..:.|.|.:.::..:|||.|        :|....    :.|.|.|:.:..|.|:||..
plant     9 QVPVGTLTSIGFSISNNNDRDKMSVLE--------VEAPNQ----VTDSRLGLPNPDSVCRTCGS 61

  Fly    73 -NMTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPHNPKIKEIVMK----SRGQ 132
             :...|.||||.|:.|..:.:..|:.:...:|..:|            |..|.|..|    :..|
plant    62 KDRKVCEGHFGVINFAYSIINPYFLKEVAALLNKIC------------PGCKYIRKKQFQITEDQ 114

  Fly   133 PRKRLAYVYDLCKGKTICEGGEDMDL---TKENQQPDPNKKPGHGGCGHYQPSIRRTGLDLTAEW 194
            |.:        |:..|:..|...|..   |||                    ..||:|:.:..
plant   115 PER--------CRYCTLNTGYPLMKFRVTTKE--------------------VFRRSGIVVEV-- 149

  Fly   195 KHQNEDS----QEKKIVVSAERVWEILKHIT--DEEC---------------FILGMDPKYARPD 238
               ||:|    :::.::......|..|...:  ||.|               .:||:|.:..:.|
plant   150 ---NEESLMKLKKRGVLTLPPDYWSFLPQDSNIDESCLKPTRRIITHAQVYALLLGIDQRLIKKD 211

  Fly   239 WMI-----VTVLPVPPLAVRPAVVMF---GAAKNQDDLTHKLSDIIK-ANNELRKNEASGAAAHV 294
            ..:     :|..||.|...|...::.   ||....|:.|.....::. ..|.|   |.|......
plant   212 IPMFNSLGLTSFPVTPNGYRVTEIVHQFNGARLIFDERTRIYKKLVGFEGNTL---ELSSRVMEC 273

  Fly   295 IQENIKMLQFHVATLVDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTVI 359
            :|.: ::....|::..|:..|     .||.....|....|.      ::..|:|||.|.:.|||:
plant   274 MQYS-RLFSETVSSSKDSANP-----YQKKSDTPKLCGLRF------MKDVLLGKRSDHTFRTVV 326

  Fly   360 TPDPNLRIDQVGVPRSIAQNLTFPE---------LVT---PFNIDRMQELVRRGNSQYPGAKYIV 412
            ..||:|:::::|:|.|||:.|...|         |||   |..:|..:..||||
plant   327 VGDPSLKLNEIGIPESIAKRLQVSEHLNQCNKERLVTSFVPTLLDNKEMHVRRG----------- 380

  Fly   413 RDNGERIDLRFHPKSSDLHLQCGYKVERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLP-WSTFRM 476
             |....|.:.        .||.|.|:.|.|.|.|.|:.||.|::|:.|::...|::|| .|...:
plant   381 -DRLVAIQVN--------DLQTGDKIFRSLMDGDTVLMNRPPSIHQHSLIAMTVRILPTTSVVSL 436

  Fly   477 NLSCTSPYNADFDGDEMNLHVPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKM- 540
            |..|..|:..|||||.::.:||||::.:.|::.:....:|:|..|..:.::.:.||:|||...:
plant   437 NPICCLPFRGDFDGDCLHGYVPQSIQAKVELDELVALDKQLINRQNGRNLLSLGQDSLTAAYLVN 501

  Fly   541 TKRDVFITREQVMNLLMFLPTWDAKMPQPCILK-----PRPLWTGKQIFSLIIPGNVNMIRTHST 600
            .:::.::.|.|:..|.|:.|   .::|.|.|:|     ..|.|||.|:|.::.|...:.     |
plant   502 VEKNCYLNRAQMQQLQMYCP---FQLPPPAIIKASPSSTEPQWTGMQLFGMLFPPGFDY-----T 558

  Fly   601 HPDEEDEGPYKWISPGDTKVMVEHGELIM------------GILCKKSLGTSAGSLLHICFLELG 653
            :|              ...|:|.:|||:.            |...::.|....|.:|.|.:
plant   559 YP--------------LNNVVVSNGELLSFSEGSAWLRDGEGNFIERLLKHDKGKVLDIIY---- 605

  Fly   654 HDIAGRFYGNIQTVINNWLLFEGHSIGIGDTI--ADPQTYNEIQQAIKKAKDDVINVIQKAHNM- 715
                     :.|.:::.|||..|.|:.:.|..  :|.|:...:.:.|.....:...|..|...|
plant   606 ---------SAQEMLSQWLLMRGLSVSLADLYLSSDLQSRKNLTEEISYGLREAEQVCNKQQLMV 661

  Fly   716 -------------ELEPTPGNTLRQTFENKVNRILN--------DARDKTGGSAKKSLTEYNNLK 759
                         :.|.:..:..|..:|.:.:..|:        ||.......|.:...:.|:..
plant   662 ESWRDFLAVNGEDKEEDSVSDLARFCYERQKSATLSELAVSAFKDAYRDVQALAYRYGDQSNSFL 726

  Fly   760 AMVVSGSKGSNINISQVIACVGQQNVEGKRIPYGF-RKRTLPHFI-----------KDDYGPES- 811
            .|..:||||:...:.|...|:|.|| ....:.:|| |:.|...:.           ||....||
plant   727 IMSKAGSKGNIGKLVQHSMCIGLQN-SAVSLSFGFPRELTCAAWNDPNSPLRGAKGKDSTTTESY 790

  Fly   812 --RGFVENSYLAGLTPSEFYFHAMGGRE----GLIDTAVKTAETGYIQRRLIKAMESVMVNYDGT 870
              .|.:|||:|.||.|.|.:.|::..|:    |..|.      .|.:.|||:..|..:...||||
plant   791 VPYGVIENSFLTGLNPLESFVHSVTSRDSSFSGNADL------PGTLSRRLMFFMRDIYAAYDGT 849

  Fly   871 VRNSVG-QLIQLRYGEDGLCGELVEFQNMPTVKLSNKSFEKRFKFDWSNERLMKKVFTDDVIKEM 934
            ||||.| ||:|..|..||           |                           .:|:..|.
plant   850 VRNSFGNQLVQFTYETDG-----------P---------------------------VEDITGEA 876

  Fly   935 TDSSEAIQELEAEWDRLVSDRD-SLRQIFPNGESKVVLPCNLQRMIWNVQKIFHINKRLPTDLSP 998
            ..|..|....||.:..|  |:. ||.:..|....|.||.|.
plant   877 LGSLSACALSEAAYSAL--DQPISLLETSPLLNLKNVLECG------------------------ 915

  Fly   999 IRVIKGVKTLLERCVIVTGNDRISKQANENATLLFQCLIRSTLCTKYVSEEFRLSTEAFEWLVGE 1063
                                   ||:.....|:           :.|:||........||:  |.
plant   916 -----------------------SKKGQREQTM-----------SLYLSEYLSKKKHGFEY--GS 944

  Fly  1064 IETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEIINISKKPKA 1128
            :|
plant   945 LE--------------------------------------------------------------- 946

  Fly  1129 PSLTVFLTGGAARDAEKAKNVLCRLEHTTLRKVTANTAIYYDPDPQRTVISEDQEFVNVYYEMPD 1193
                             .||   .||..:..::.:.:.|.:.|.....|
plant   947 -----------------IKN---HLEKLSFSEIVSTSMIIFSPSSNTKV---------------- 975

  Fly  1194 FDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINVGFG---------------EDLNCIFNDDN 1243
                .:|||:....:..|.:..|:|:.|.:...:|..:.               ::.|...:||.
plant   976 ----PLSPWVCHFHISEKVLKRKQLSAESVVSSLNEQYKSRNRELKLDIVDLDIQNTNHCSSDDQ 1036

  Fly  1244 A---DKLVLRIRIMNNEENKFQDEDEAVDKMEDDMFLRCIEANMLSDMTLQGIEAIGKVYMHLPQ 1305
            |   |.:.:.:.::...::...:.|.          :|.:....|.|..::|.:.|.||  ::..
plant  1037 AMKDDNVCITVTVVEASKHSVLELDA----------IRLVLIPFLLDSPVKGDQGIKKV--NILW 1089

  Fly  1306 TDSKKR-------------IVITETGEFKAIGEW--LLETDGTSMMKVLSERDVDPIRTSSNDIC 1355
            ||..|.             :.:|..|:......|  ||||    .:.::..  :|..|:..::|.
plant  1090 TDRPKAPKRNGNHLAGELYLKVTMYGDRGKRNCWTALLET----CLPIMDM--IDWGRSHPDNIR 1148

  Fly  1356 EIFQVLGIEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINRQ----DT 1416
            :...|.||:|.|......:.:.:...|..:...||.|:.|.::..|..:|:...|.::|    .|
plant  1149 QCCSVYGIDAGRSIFVANLESAVSDTGKEILREHLLLVADSLSVTGEFVALNAKGWSKQRQVEST 1213

  Fly  1417 GA-LMRCSFEETVDVLMDAAAHAETDPMRGVSENIIMGQLPKMGTG------------------- 1461
            .| ..:..|.......:.||.....|.::|..:.:..|::|..|||
plant  1214 PAPFTQACFSSPSQCFLKAAKEGVRDDLQGSIDALAWGKVPGFGTGDQFEIIISPKVHGFTTPVD 1278

  Fly  1462 CFDLLLDAEKCR---------------FGIEIPNTLGNSMLGGAAMFIGGGSTPSMTPPMTPWAN 1511
            .:|||...:..|               ||:     |.::.|....:..|.|...|:...:..|.|
plant  1279 VYDLLSSTKTMRRTNSAPKSDKATVQPFGL-----LHSAFLKDIKVLDGKGIPMSLLRTIFTWKN 1338

Fly 1512 1511
plant 1339 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII215	NP_511124.1	PRK08566	14..887	CDD:236292	239/985 (24%)
		RNAP_II_RPB1_N	15..868	CDD:259848	226/964 (23%)
		RNA_pol_Rpb1_5	822..1420	CDD:282807	111/641 (17%)
		RNA_pol_Rpb1_6	890..1071	CDD:282801	26/181 (14%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	74/474 (16%)
		TCRP1	1602..1880	CDD:291605
		RCR	<1789..1864	CDD:304939
NRPD1A	NP_001185298.1	RNAP_IV_RPD1_N	23..851	CDD:259849	228/961 (24%)
		RNAP_IV_NRPD1_C	874..1266	CDD:132724	91/574 (16%)
		DUF3223	1349..1419	CDD:371580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19376
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910