Protein Alignment RpII215 and NRPA1

DIOPT Version :9

• Sequence 1: NP_511124.1
• Gene: RpII215 / 32100
• FlyBaseID: FBgn0003277
• Length: 1887
• Species: Drosophila melanogaster
• Sequence 2: NP_191325.1
• Gene: NRPA1 / 824935
• AraportID: AT3G57660
• Length: 1670
• Species: Arabidopsis thaliana
• Alignment Length: 1813
• Identity: 453/1813 - (24%)
• Similarity: 727/1813 - (40%)
• Gaps: 526/1813 - (29%)

  Fly    14 VKRVQFGILSPDEIRRMS-------VTEGGVQFAETMEGGRPKLGGLMDPRQGVIDRTSRCQTCA 71
            |:.|:|..::..::|:.|       :....|        |.|..|||.|.:.|..|....|.:|.
plant    27 VESVRFSFMTEQDVRKHSFLKVTSPILHDNV--------GNPFPGGLYDLKLGPKDDKQACNSCG 83

  Fly    72 GNMTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPHNPKIKEIVMKSRGQPRKR 136
            .....||||.|||:|..|::|..........|:..||:|...:..|.:.:        |...:.:
plant    84 QLKLACPGHCGHIELVFPIYHPLLFNLLFNFLQRACFFCHHFMAKPEDVE--------RAVSQLK 140

  Fly   137 LAYVYDLCKGKTI--------------CEGGEDMDLTKENQQPDPN------------------- 168
            |....|:...|.:              ||.....|.::|.:..|..
plant   141 LIIKGDIVSAKQLESNTPTKSKSSDESCESVVTTDSSEECEDSDVEDQRWTSLQFAEVTAVLKNF 205

  Fly   169 ---KKPGHGGCGHYQPSIRR-----------------------------------------TGLD 189
               .......|....|.:.:                                         :|:|
plant   206 MRLSSKSCSRCKGINPKLEKPMFGWVRMRAMKDSDVGANVIRGLKLKKSTSSVENPDGFDDSGID 270

  Fly   190 LTAEWKHQNEDSQEKKIVVSAE-------------RVWEILKHITDEE---CFILG-----MDPK 233
            ..:|.:..:::::||...|:||             .|..||||:...|   |..:|     ...|
plant   271 ALSEVEDGDKETREKSTEVAAEFEEHNSKRDLLPSEVRNILKHLWQNEHEFCSFIGDLWQSGSEK 335

  Fly   234 YARPDWMIVTVLPVPPLAVRPAVVMFGAAKNQDDLTHKLSDIIKANNELRKNEASGAAAHVIQEN 298
            .....:.:.:|| |||...||... .|.:..:...|..|:.:|::||.|     ..|..:.:.::
plant   336 IDYSMFFLESVL-VPPTKFRPPTT-GGDSVMEHPQTVGLNKVIESNNIL-----GNACTNKLDQS 393

  Fly   299 -----IKMLQFHVATLVDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTV 358
                 .:.||..|..|.|:....:......||     |...|:.|||..|..:|||||:.:.|:|
plant   394 KVIFRWRNLQESVNVLFDSKTATVQSQRDSSG-----ICQLLEKKEGLFRQKMMGKRVNHACRSV 453

  Fly   359 ITPDPNLRIDQVGVPRSIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKY------------- 410
            |:|||.:.::.:|:|...|..||:||.|||:|:::::|.:..|...:|||.:
plant   454 ISPDPYIAVNDIGIPPCFALKLTYPERVTPWNVEKLREAIINGPDIHPGATHYSDKSSTMKLPST 518

  Fly   411 ----------IVRDNGERIDLRFHPKSSDLHLQCGYKVERHLRDDDLVIFNRQPTLHKMSMMGHR 465
                      ::...|...:|   .|:.|::.: |..|.||:||.|:|:.||||||||.|:|.|:
plant   519 EKARRAIARKLLSSRGATTEL---GKTCDINFE-GKTVHRHMRDGDIVLVNRQPTLHKPSLMAHK 579

  Fly   466 VKVLPW-STFRMNLSCTSPYNADFDGDEMNLHVPQSMETRAEVENIHITPRQIITPQANKPVMGI 529
            |:||.. .|.|::.:..|.|||||||||||:|.||...:|||..||.....|...|...:|:..:
plant   580 VRVLKGEKTLRLHYANCSTYNADFDGDEMNVHFPQDEISRAEAYNIVNANNQYARPSNGEPLRAL 644

  Fly   530 VQDTLTAVRKMTKRDVFITREQVMNLL-------MFLPTW-------------DAKM--PQPCIL 572
            :||.:.:...:||||.|:.::....||       |.|.|:             ||::  ..|.||
plant   645 IQDHIVSSVLLTKRDTFLDKDHFNQLLFSSGVTDMVLSTFSGRSGKKVMVSASDAELLTVTPAIL 709

  Fly   573 KPRPLWTGKQIFSLI------------------IPGNVNMIRTHSTHPDEEDEGPYKWISP---- 615
            ||.|||||||:.:.:                  :|.:....|:....|:..|....|.|..
plant   710 KPVPLWTGKQVITAVLNQITKGHPPFTVEKATKLPVDFFKCRSREVKPNSGDLTKKKEIDESWKQ 774

  Fly   616 --GDTKVMVEHGELIMGILCKKSLGTSAGSLLHICFLELGHDIAGRFYGNIQTVINNWLLFEGHS 678
              .:.|:.:...|.:.|::.|......  .|:|......|.:.||........:...:|...|.:
plant   775 NLNEDKLHIRKNEFVCGVIDKAQFADY--GLVHTVHELYGSNAAGNLLSVFSRLFTVFLQTHGFT 837

  Fly   679 IGIGDTIADPQTYNEIQQAIKKAKDDVINVIQKAH----NMELEPTPGNTLRQTFENKVNRILND 739
            .|:.|.|.......|..:.:::.::....|::|..    :::::|       |...:::.|||.:
plant   838 CGVDDLIILKDMDEERTKQLQECENVGERVLRKTFGIDVDVQIDP-------QDMRSRIERILYE 895

  Fly   740 ARDKTGGSAKKSLTEY------------------------NNLKAMVVSGSKGSNINISQVIACV 780
            ..:....|..:|:..|                        |.:..|.:||:|||.:|..|:.:.:
plant   896 DGESALASLDRSIVNYLNQCSSKGVMNDLLSDGLLKTPGRNCISLMTISGAKGSKVNFQQISSHL 960

  Fly   781 GQQNVEGKRIPYGFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVK 845
            |||::||||:|.....:|||.|...|:.|.:.||:.:.:|:||.|.|:|||.|.|||||:|||||
plant   961 GQQDLEGKRVPRMVSGKTLPCFHPWDWSPRAGGFISDRFLSGLRPQEYYFHCMAGREGLVDTAVK 1025

  Fly   846 TAETGYIQRRLIKAMESVMVNYDGTVRNSVGQLIQLRYGEDGLCGELVEFQNMPTVKLSNKSFEK 910
            |:.:||:||.|:|.:||:.||||.|||::.|.:||.:|||||             |.:...||.:
plant  1026 TSRSGYLQRCLMKNLESLKVNYDCTVRDADGSIIQFQYGEDG-------------VDVHRSSFIE 1077

  Fly   911 RFKFDWSNERLMKKVFTDDVIKEMTDSSEAIQELEAEWDRLVSDRDSLRQIFPNGESKVVLPCNL 975
            :||....|:.::.:..::|::                                :|.|..:
plant  1078 KFKELTINQDMVLQKCSEDML--------------------------------SGASSYI----- 1105

  Fly   976 QRMIWNVQKIFHINKRLPTDLSPIRVIKGVKTLLERCVIVTGNDRISKQANENATLLFQCLIRST 1040
                              :|| ||.:.||.:..:|...:   |:||:
plant  1106 ------------------SDL-PISLKKGAEKFVEAMPM---NERIA------------------ 1130

  Fly  1041 LCTKYVSEEFRLSTEAFEWLVGEIETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFAGVS 1105
              :|:|.:|..|..         ::::|..:.|.|||.||.|||||:|||:|||||||||.||..
plant  1131 --SKFVRQEELLKL---------VKSKFFASLAQPGEPVGVLAAQSVGEPSTQMTLNTFHLAGRG 1184

  Fly  1106 SKNVTLGVPRLKEII-----NISKKPKAPSLTVFLTGGAARDAEKAKNVLCRLEHTTLRKVTANT 1165
            ..|||||:|||:||:     ||    |.|.:|..|..|..:  |.|.::..||...|:..:..:.
plant  1185 EMNVTLGIPRLQEILMTAAANI----KTPIMTCPLLKGKTK--EDANDITDRLRKITVADIIKSM 1243

  Fly  1166 -------AIY--------------YDPD--PQRTVISEDQEFVNVYYEMPDFDPTRISPWLLRIE 1207
                   .:|              |.|:  |:.|.|:|:           |::.|..:.:|.::|
plant  1244 ELSVVPYTVYENEVCSIHKLKINLYKPEHYPKHTDITEE-----------DWEETMRAVFLRKLE 1297

  Fly  1208 ---------LDRKRMTDKKLT----------MEQIAEKINV------GFGEDLNCIFNDDNADKL 1247
                     |.|.|.....:|          .:.::.|.|.      |.|.:::.:.:|....|
plant  1298 DAIETHMKMLHRIRGIHNDVTGPIAGNETDNDDSVSGKQNEDDGDDDGEGTEVDDLGSDAQKQK- 1361

  Fly  1248 VLRIRIMNNEENK-------------------FQDEDEAVDK------MEDDM------------ 1275
            ......|:.|||.                   .::||..|.|      .|:.|
plant  1362 KQETDEMDYEENSEDETNEPSSISGVEDPEMDSENEDTEVSKEDTPEPQEESMEPQKEVKGVKNV 1426

  Fly  1276 ----------FLRC---------------------------IEANMLSDMTLQGIEAIGKVYMHL 1303
                      |:|.                           |....::..|.|      |||:
plant  1427 KEQSKKKRRKFVRAKSDRHIFVKGEGEKFEVHFKFATDDPHILLAQIAQQTAQ------KVYI-- 1483

  Fly  1304 PQTDSK-KRIVITETGEFKAI------------------GEWLLETDGTSMMKVLSERDVDPIR- 1348
             |...| :|..:...|:.:.|                  ....|...|.....:...:|...:|
plant  1484 -QNSGKIERCTVANCGDPQVIYHGDNPKERREISNDEKKASPALHASGVDFPALWEFQDKLDVRY 1547

  Fly  1349 TSSNDICEIFQVLGIEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINR 1413
            ..||.|.::..:.|:||.|:::.:|:|.|.:.||:.|:.|||.|:.|.||..|....::|.|...
plant  1548 LYSNSIHDMLNIFGVEAARETIIREINHVFKSYGISVSIRHLNLIADYMTFSGGYRPMSRMGGIA 1612

  Fly  1414 QDTGALMRCSFEETVDVLMDAAAHAETDPMRGVSENIIMGQLPKM-GTGCFDLLLDAE 1470
            :.|....|.:||.....::.||.:.|.|.:...|..|.:| ||.: |||||||:...|
plant  1613 ESTSPFCRMTFETATKFIVQAATYGEKDTLETPSARICLG-LPALSGTGCFDLMQRVE 1669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpII215	NP_511124.1	PRK08566	14..887	CDD:236292	288/1080 (27%)
		RNAP_II_RPB1_N	15..868	CDD:259848	276/1060 (26%)
		RNA_pol_Rpb1_5	822..1420	CDD:282807	185/744 (25%)
		RNA_pol_Rpb1_6	890..1071	CDD:282801	24/180 (13%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	140/565 (25%)
		TCRP1	1602..1880	CDD:291605
		RCR	<1789..1864	CDD:304939
NRPA1	NP_191325.1	PRK14977	23..1668	CDD:184940	452/1810 (25%)
		RNAP_I_RPA1_N	31..1048	CDD:259844	275/1057 (26%)
		RNAP_I_Rpa1_C	1146..1665	CDD:132722	138/546 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820