DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII215 and RpI1

DIOPT Version :9

Sequence 1:	NP_511124.1	Gene:	RpII215 / 32100	FlyBaseID:	FBgn0003277	Length:	1887	Species:	Drosophila melanogaster
Sequence 2:	NP_523743.1	Gene:	RpI1 / 36617	FlyBaseID:	FBgn0019938	Length:	1642	Species:	Drosophila melanogaster

Alignment Length:	1755	Identity:	492/1755 - (28%)
Similarity:	768/1755 - (43%)	Gaps:	437/1755 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VQFGILSPDEIRRMSVTE--GGVQFAETMEGGRPKLGGLMDPRQGVIDR-TSRCQTCAGNMTECP 78
            ::|.:.:..|||::||.:  .|:.|...   |....|||.|.|.|...| ...|.||. .:.:||
  Fly    16 LEFAVFTDQEIRKLSVVKVITGITFDAL---GHAIPGGLYDIRMGSYGRCMDPCGTCL-KLQDCP 76

  Fly    79 GHFGHIDLAKPVFHIGFITKTIKILRCV-CFYCSKMLVSPHNPKIKEIVMKSRGQPRKRL----- 137
            ||.|||:|..||::..|| |.::.|.|: |.:|.|:.:..|.   .||:|.     :.||
  Fly    77 GHMGHIELGTPVYNPFFI-KFVQRLLCIFCLHCYKLQMKDHE---CEIIML-----QLRLIDAGY 132

  Fly   138 ---AYVYDLCKGKTICEGGEDMDLTKENQQPDP-----------NKKPGHGG------------- 175
               |...:|.|.:.:|:..|::...|......|           |:|.....
  Fly   133 IIEAQELELFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAITH 197

  Fly   176 ---------CGHYQPSIRRTGLDLTAEWKHQN------------------EDSQEKKIVVSAE-- 211
                     |.|...|:|      ...:.|:.                  |...:.|::.:.|
  Fly   198 SALQRLGKKCRHCNKSMR------FVRYMHRRLVFYVTLADIKERVGTGAETGGQNKVIFADECR 256

  Fly   212 ----RVW----EILKHITDEECFILGM------DPKYARPDWMIVTVLPVPPLAVRPAVVMFGAA 262
                :::    |:||.:..    :||:      ....:..|...:..|||.|...||..::....
  Fly   257 RYLRQIYANYPELLKLLVP----VLGLSNTDLTQGDRSPVDLFFMDTLPVTPPRARPLNMVGDML 317

  Fly   263 KN--QDDL-------THKLSDII---KANNELRKNEA-------SGAAAHVIQENI----KMLQF 304
            |.  |.|:       .|.|:.::   |...|....||       .|..||   |.:    ..||.
  Fly   318 KGNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAH---EKLYTAWLALQM 379

  Fly   305 HVATLVDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRIDQ 369
            .|..|:|   ..|.|.| |||:.||.|   ::.|.|.||.::|||||:::||||||||||:.:|:
  Fly   380 SVDVLLD---VNMSREM-KSGEGLKQI---IEKKSGLIRSHMMGKRVNYAARTVITPDPNINVDE 437

  Fly   370 VGVPRSIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKYIVRDNG-------------ERID- 420
            :|:|...|:.|::|..||.:|:..::::|..|...:|||.||...||             |.:.
  Fly   438 IGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPADNASKRESLAK 502

  Fly   421 -LRFHPKSSDLHLQCGYK-VERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLPW-STFRMNLSCTS 482
             |..:||.       |.| |.||:.:.|:::.||||:|||.|:|||:.::|.. .|||::.|...
  Fly   503 LLLSNPKD-------GIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCK 560

  Fly   483 PYNADFDGDEMNLHVPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVFI 547
            .|||||||||||.|.|||...|||..|:.......:.|:...|:.|::||.:.:..|::.|..|.
  Fly   561 AYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFF 625

  Fly   548 TREQVMNLL---MFLPTWDAKMPQPCILKPRPLWTGKQIFSLIIPG------------------- 590
            .||....|:   :.....|.|:..|.||||..||:||||.|.||..
  Fly   626 NREDYQQLVFQGLSQLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYERINLDSFAKIAG 690

  Fly   591 -NVNMIRTH----STHPDEEDEGPYKWISPGDTKVMVEHGELIMGILCKKSLGTSAGSLLHICFL 650
             |.|:.|..    .|:|:..|        ..:::|.:.:|||::|:|.|:..|.:...|:| |..
  Fly   691 KNWNVSRPRPPICGTNPEGND--------LSESQVQIRNGELLVGVLDKQQYGATTYGLIH-CMY 746

  Fly   651 EL-GHDIAGRFYGNIQTVINNWLLFEGHSIGIGDTIADPQTYNEIQQAIKKAKDDVINVIQKAHN 714
            || |.|::.........|...:|..||.::|:.|.:.......:.::.|::.::...:.:..|..
  Fly   747 ELYGGDVSTLLLTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAAALE 811

  Fly   715 MELEPTPGNTLRQTFE-----NKVNRILNDARDKT---GGS--------AKKSLTEY--NNLKAM 761
            :|.|| |.:.|.:..|     :...|:|.|.:.|:   |.:        .:..:|::  |||:.|
  Fly   812 LEDEP-PHDELVEKMEAAYVKDSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLM 875

  Fly   762 VVSGSKGSNINISQVIACVGQQNVEGKRIPYGFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPS 826
            |:||:|||.:|..|:...:||..:||||.|.....::||.|...:..|:|.||::..::.|:.|.
  Fly   876 VLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQPQ 940

  Fly   827 EFYFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVNYDGTVRNSVGQLIQLRYGEDGLCGE 891
            :|:||.|.||||||||||||:.:||:||.|||.:|.:.|:||.|||:|...::|..||||||  :
  Fly   941 DFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGL--D 1003

  Fly   892 LVEFQNMPTVKLSNKSFEKRFKFDWSNERLMKKVFTDDVIKEMTDSSEAIQELEAEWDRLVSDRD 956
            :          |.:|.|..:|..|:                 :|.::.||  |.....:|:.|.:
  Fly  1004 I----------LKSKFFNDKFCADF-----------------LTQNATAI--LRPAQLQLMKDEE 1039

  Fly   957 SLRQIFPNGESKVVLPCNLQR-----MIWNVQK-------IFHINKRLPTDLSPIRVIKGVKTLL 1009
            .|.::              ||     ..|..:|       ..|.::.|..::.    :|....:.
  Fly  1040 QLAKV--------------QRHEKHIRSWEKKKPAKLRAAFTHFSEELREEVE----VKRPNEIN 1086

  Fly  1010 ERCVIVTGNDRIS-------KQANENATLLFQ-----------CLIRSTLCTKYVSEEFR-LSTE 1055
            .:    ||..|..       |:|:.....|::           .:.:..|....|||..| |.|:
  Fly  1087 SK----TGRRRFDEGLLKLWKKADAEDKALYRKKYARCPDPTVAVYKQDLYYGSVSERTRKLITD 1147

  Fly  1056 ------AFEWLVGEI-ETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKNVTLGV 1113
                  |.:..:.:| ..:..::.|.|||.||.:||||:|||:||||||||||||....|||||:
  Fly  1148 YAKRKPALKETIADIMRVKTIKSLAAPGEPVGLIAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGI 1212

  Fly  1114 PRLKEIINI-SKKPKAPSLTVFLTGGAARDAEKAKNVLCRLEHTTLRK----VTANTAIYYDPDP 1173
            |||:||:.: |...|.||:.:.:..|....|||.:   ..|...||..    |..:|.:..||:.
  Fly  1213 PRLREILMLASSNIKTPSMDIPIKPGQQHQAEKLR---INLNSVTLANLLEYVHVSTGLTLDPER 1274

  Fly  1174 QRTVISEDQEFV----NVYYEMPDFDPTRISPW--------LLR--------------IELDRKR 1212
            .   ...|..|.    .||.|.....|..|..:        |:|              :.:|.|:
  Fly  1275 S---YEYDMRFQFLPREVYKEDYGVRPKHIIKYMHQTFFKQLIRAILKVSNASRTTKIVVIDDKK 1336

  Fly  1213 MTDKKLTMEQIAEKINVGFGEDLNCIFN-----------------DDNAD------KL------- 1247
            ..||                ||.|.:.|                 |||.|      ||
  Fly  1337 DADK----------------EDDNDLDNGDEVGRSKAKANDDDSSDDNDDDDATGVKLKQRKTDE 1385

  Fly  1248 --------VLRIRIMNNEENKFQDEDE---------------AVDK-MEDDM----------FLR 1278
                    |..:...|:::::.:|||:               ||:: :.:||          .|.
  Fly  1386 KDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGDDKAVERLLSNDMVKAYTYDKENHLW 1450

  Fly  1279 C-IEANM-----LSDMTLQGIEAIGKVYMHLPQTDSKKRIVITETGEFKAIGEWLLETDGTSMMK 1337
            | ::.|:     ..|:|....|..||..:|  |....||.:|.:..:    .:.||:|||.::.:
  Fly  1451 CQVKLNLSVRYQKPDLTSIIRELAGKSVVH--QVQHIKRAIIYKGTD----DDQLLKTDGINIGE 1509

  Fly  1338 VLSERDV-DPIRTSSNDICEIFQVLGIEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKG 1401
            :.....: |..|..||||..|.:..||||..:.:.||::.|.:.||:.|:.|||:|:.|.||..|
  Fly  1510 MFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVYGITVDRRHLSLIADYMTFDG 1574

  Fly  1402 HLMAITRHGINRQDTGALMRCSFEETVDVLMDAAAHAETDPMRGVSENIIMGQLPKMGTGCFDLL 1466
            ....::|.|: ...:..|.:.|||.::..|..||.....|.:...|..:::|...:.|||.|:||
  Fly  1575 TFQPLSRKGM-EHSSSPLQQMSFESSLQFLKSAAGFGRADELSSPSSRLMVGLPVRNGTGAFELL 1638

Fly 1467 1466
Fly 1639 1638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII215	NP_511124.1	PRK08566	14..887	CDD:236292	312/1034 (30%)
		RNAP_II_RPB1_N	15..868	CDD:259848	302/1015 (30%)
		RNA_pol_Rpb1_5	822..1420	CDD:282807	201/737 (27%)
		RNA_pol_Rpb1_6	890..1071	CDD:282801	34/218 (16%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	148/527 (28%)
		TCRP1	1602..1880	CDD:291605
		RCR	<1789..1864	CDD:304939
RpI1	NP_523743.1	RNA_pol_rpoA1	14..1009	CDD:274106	316/1054 (30%)
		RNAP_I_RPA1_N	18..982	CDD:259844	302/1013 (30%)
		RNA_pol_Rpb1_5	936..1593	CDD:282807	202/738 (27%)
		HMG-box	1057..1119	CDD:294061	10/69 (14%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	141/500 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	293	1.000	Inparanoid score	I87
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11825at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51395
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900