DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpII215 and POLR1A

DIOPT Version :9

Sequence 1:NP_511124.1 Gene:RpII215 / 32100 FlyBaseID:FBgn0003277 Length:1887 Species:Drosophila melanogaster
Sequence 2:NP_056240.2 Gene:POLR1A / 25885 HGNCID:17264 Length:1720 Species:Homo sapiens


Alignment Length:1836 Identity:468/1836 - (25%)
Similarity:741/1836 - (40%) Gaps:508/1836 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PLRQVKRVQFGILSPDEIRRMSVTE-GGVQFAETMEGGRPKLGGLMDPRQGVIDRTSRCQTCAGN 73
            |.|:::.:.||:.|.:|::::||.. ...::.:::  |.|...||.|...|..|....|.||..:
Human     8 PWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSL--GNPSANGLYDLALGPADSKEVCSTCVQD 70

  Fly    74 MTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPH-------------------- 118
            .:.|.||.|||:|...|::.....|...:||..|..| .||..|.                    
Human    71 FSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNC-HMLTCPRAVIHLLLCQLRVLEVGALQA 134

  Fly   119 ----------------NPKIKEI---------------VMKSRGQPRKRLAYVYDLCKGKT---- 148
                            :|...||               ::.|:|      |:|.::|:.|:    
Human   135 VYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQG------AHVKNVCESKSKLIA 193

  Fly   149 -------------ICEGGEDM-------DLT------------KENQQPDPNKKPGHGGCGHYQP 181
                         .|:.|..:       .||            :::.:|...::...|..|:..|
Human   194 LFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDSEPLGIEEAQIGKRGYLTP 258

  Fly   182 SIRRTGLDLTAEWKHQNEDSQEKKIVVSAERVWEILKHI---TDEECFILGMDPKYARPDWMIVT 243
            :..|.  .|:|.||::.                ..|.::   .|::    ||:.:: .|....:.
Human   259 TSARE--HLSALWKNEG----------------FFLNYLFSGMDDD----GMESRF-NPSVFFLD 300

  Fly   244 VLPVPPLAVRPAVVMFGAAKNQDDLTHKLSDIIKANNELRKNEASGAAAHVIQENIK-------- 300
            .|.|||...|| |...|.....:..|..|..::|....:||..|..|....:.|.:.        
Human   301 FLVVPPSRYRP-VSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTTDEEK 364

  Fly   301 ----------------------------MLQFHVATLVDNDM--------PGMPRAMQKSGKPLK 329
                                        .||.||..:.|::|        ||:.:.::|      
Human   365 DSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQILEK------ 423

  Fly   330 AIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRIDQVGVPRSIAQNLTFPELVTPFNIDRM 394
                    |||..|.::||||||::||:||.||..:..:::|:|...|..||:|:.|||:|:..:
Human   424 --------KEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL 480

  Fly   395 QELVRRGNSQYPGAKYIVRDNGER-----IDLRFH--------------PKSSDLHLQCGYKVER 440
            ::.|..|.:.:|||..::.::|.|     :|:...              ||.....:.|     |
Human   481 RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVC-----R 540

  Fly   441 HLRDDDLVIFNRQPTLHKMSMMGHRVKVLP-WSTFRMNLSCTSPYNADFDGDEMNLHVPQSMETR 504
            |:::.|:::.|||||||:.|:..||.::|| ....|::.:....|||||||||||.|.|||...|
Human   541 HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGR 605

  Fly   505 AEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVFITREQVMNLLMFLPTWD----AK 565
            ||...:..|.:|.:.|:..:|:.|::||.:.:...||.|..|.|||..|. |::....|    .|
Human   606 AEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYME-LVYRGLTDKVGRVK 669

  Fly   566 MPQPCILKPRPLWTGKQIFSLIIPGNVNMIRTHSTHPDEEDEGPYK-----------WIS----- 614
            :..|.||||.|||||||:.|.::   :|:|        .||..|..           |:.     
Human   670 LLSPSILKPFPLWTGKQVVSTLL---INII--------PEDHIPLNLSGKAKITGKAWVKETPRS 723

  Fly   615 -PG-------DTKVMVEHGELIMGILCKKSLGTSAGSLLHICFLELGHDIAGRFYGNIQTVINNW 671
             ||       :::|::..|||:.|:|.|...|:||..|:|.|:...|.:.:|:....:..:...:
Human   724 VPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTCLARLFTAY 788

  Fly   672 L-LFEGHSIGIGDTIADPQTYNEIQQAIKKAK-------------------DDVINVIQKAHNME 716
            | |:.|.::|:.|.:..|:...:.|:.|:::.                   |:|....|.|| :.
Human   789 LQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYDEVRGKWQDAH-LG 852

  Fly   717 LEPTPGNTLRQTFENKVNRILNDARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINISQVIACVG 781
            .:....|.:...|:.:||...|:................|:|:.||.||:|||.:|..|:...:|
Human   853 KDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQSGAKGSTVNTMQISCLLG 917

  Fly   782 QQNVEGKRIPYGFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKT 846
            |..:||:|.|.....::||.|...::.|.:.|||...:|.|:.|.||:||.|.|||||:||||||
Human   918 QIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKT 982

  Fly   847 AETGYIQRRLIKAMESVMVNYDGTVRNSVGQLIQLRYGEDGLCGELVEFQNMPTVKLSNKSFEKR 911
            :.:||:||.:||.:|.::|.||.|||:|.|.::|..||||||        ::|..:...   .|:
Human   983 SRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGL--------DIPKTQFLQ---PKQ 1036

  Fly   912 FKFDWSN-ERLMKKVFTDDVIKEMTDSSEAIQELEA--EWDRLVSDRDSLRQIFPNGESKVVLPC 973
            |.|..|| |.:||.....:|:.. .|..:|:....|  :|.....:....|..|.:...|:    
Human  1037 FPFLASNYEVIMKSQHLHEVLSR-ADPKKALHHFRAIKKWQSKHPNTLLRRGAFLSYSQKI---- 1096

  Fly   974 NLQRMIWNVQKIFHINKRLPTDLSPIRVIKGVKTLLERCVIVTGNDRISKQANENATLLFQ---- 1034
              |..:    |...:........||     |.:.:|          |:..:.:|.:...:|    
Human  1097 --QEAV----KALKLESENRNGRSP-----GTQEML----------RMWYELDEESRRKYQKKAA 1140

  Fly  1035 -C------LIRSTLCTKYVSEEFRLSTEAF--EW-----------------LVGEIETRFQQAQA 1073
             |      :.|..:....|||.|....:.:  ||                 |...::.::|::..
Human  1141 ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKWQRSLC 1205

  Fly  1074 NPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEIINI-SKKPKAP--SLTVFL 1135
            .|||.||.|||||:|||:||||||||||||....|||||:|||:||:.: |...|.|  |:.|..
Human  1206 EPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVLN 1270

  Fly  1136 TGGAARDAEKAKNVLCR----------------------------------LEH----------- 1155
            |..|.:..:..|..|.|                                  |.|           
Human  1271 TKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQFLPHAYYQQEKCLRP 1335

  Fly  1156 --------------------------TTLRKVTANTAIYYDPD----------PQRTVISEDQEF 1184
                                      :..|.|....|...|.|          .|.....|:...
Human  1336 EDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNAGELGRSRGEQEGDEEEEGHI 1400

  Fly  1185 VNVYYEMPDFDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINVGFGEDLNCIFNDDNADKLVL 1249
            |:...|..|.|.:           |.||...::..::..:|:.....||:     |||..     
Human  1401 VDAEAEEGDADAS-----------DAKRKEKQEEEVDYESEEEEEREGEE-----NDDED----- 1444

  Fly  1250 RIRIMNNEEN-------KFQDEDEAVD-KMEDDMFLRCI---EANMLSDMTLQGIEAIGK----- 1298
                |..|.|       |.|::||.|. ..|:|..|..:   ..........||.||:.:     
Human  1445 ----MQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMERRVQAV 1505

  Fly  1299 ---------------------VYMHLP----------------------QTDSKKRIVITETGEF 1320
                                 |.:.||                      .|....|.::.||...
Human  1506 REIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGITRCLLNETTNN 1570

  Fly  1321 KAIGEWLLETDGTSMMKVLSERDV-DPIRTSSNDICEIFQVLGIEAVRKSVEKEMNAVLQFYGLY 1384
            |...|.:|.|:|.::.::....:| |..|..||||..|....||||..:.:|||:..|...||:.
Human  1571 KNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIA 1635

  Fly  1385 VNYRHLALLCDVMTAKGHLMAITRHGINRQDTGALMRCSFEETVDVLMDAAAHAETDPMRGVSEN 1449
            |:.|||:|:.|.|..:|....:.|.|| |.::..|.:.:||.:...|..|......|.:|..|..
Human  1636 VDPRHLSLVADYMCFEGVYKPLNRFGI-RSNSSPLQQMTFETSFQFLKQATMLGSHDELRSPSAC 1699

  Fly  1450 IIMGQLPKMGTGCFDL 1465
            :::|::.:.|||.|:|
Human  1700 LVVGKVVRGGTGLFEL 1715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpII215NP_511124.1 PRK08566 14..887 CDD:236292 289/1075 (27%)
RNAP_II_RPB1_N 15..868 CDD:259848 278/1055 (26%)
RNA_pol_Rpb1_5 822..1420 CDD:282807 200/774 (26%)
RNA_pol_Rpb1_6 890..1071 CDD:282801 36/213 (17%)
RNAP_II_Rpb1_C 1050..1468 CDD:132720 143/579 (25%)
TCRP1 1602..1880 CDD:291605
RCR <1789..1864 CDD:304939
POLR1ANP_056240.2 PRK08566 4..1025 CDD:236292 294/1089 (27%)
RNAP_I_RPA1_N 16..1004 CDD:259844 278/1052 (26%)
RNA_pol_Rpb1_5 958..1671 CDD:282807 201/775 (26%)
Bridging helix. /evidence=ECO:0000250 961..973 7/11 (64%)
RNAP_I_Rpa1_C 1199..1716 CDD:132722 139/543 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1365..1498 34/157 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0086
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D591636at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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