DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII215 and rpc1

DIOPT Version :9

Sequence 1:	NP_511124.1	Gene:	RpII215 / 32100	FlyBaseID:	FBgn0003277	Length:	1887	Species:	Drosophila melanogaster
Sequence 2:	NP_595506.1	Gene:	rpc1 / 2541094	PomBaseID:	SPBC651.08c	Length:	1405	Species:	Schizosaccharomyces pombe

Alignment Length:	1546	Identity:	515/1546 - (33%)
Similarity:	781/1546 - (50%)	Gaps:	239/1546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTPTDSKAPLRQVKRVQFGILSPDEIRRMSVTEGGVQFAE----TMEGGRPKLGGLMDPRQGVI 61
            |..|.|.:.| :::|.:||||..|:|.    |.:|.|:.:.    ||....|...|.:|...|..
pombe     1 MKDPIDDQIP-KRIKHLQFGINGPEEF----VKDGTVEVSRRDLYTMTDRSPAEHGALDLHMGTS 60

  Fly    62 DRTSRCQTCAGNMTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPHNPK--IKE 124
            ::...|.||..:|.:|.||||::.||.||||||:...|:.||:.:|..||.:|:|....:  :|:
pombe    61 NKQINCATCGESMADCMGHFGYVKLALPVFHIGYFKATLTILQNICKDCSSVLLSDQEKRQFLKD 125

  Fly   125 IVMKS-----RGQPRKRLAYVYDLCKGKTICEGGEDMDLTKENQQPDPNKKPGHGGCGHYQPSIR 184
            :....     |.|..||   :.|.||....|        :|.:......||.|.....|.:....
pombe   126 LRRPGIDNLRRSQICKR---INDHCKKMRRC--------SKCDAMQGVVKKAGPLKIIHERFRYV 179

  Fly   185 RTGLDLTAEWKHQNEDS----QEKKIVVSAE-------RVWEILKHITDEECFILGMDPKYARPD 238
            |...|....::|..:::    .|.|:.:|..       :|..:.|.||..:|.:|||||::.||:
pombe   180 RKSQDDEENFRHSFDEALKTIPELKMHLSKAHDDLNPLKVLNLFKQITPVDCELLGMDPEHGRPE 244

  Fly   239 WMIVTVLPVPPLAVRPAVVMFGAAKNQDDLTHKLSDIIKANNELRKNEASGAAAHVIQENIKMLQ 303
            .::...:|.||:.:||:|...||. .:||||.|:::||..::.:|...:.|.....:.|..:.:|
pombe   245 NLLWRYVPAPPVCIRPSVAQEGAT-TEDDLTVKITEIIWTSSLIRAALSKGTPISNLMEQWEFMQ 308

  Fly   304 FHVATLVDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRID 368
            ..:|..::::|||: |......||::....|||||:||.||||.|||||||.||||:||||||||
pombe   309 LSIAMYINSEMPGL-RPSDMPSKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRID 372

  Fly   369 QVGVPRSIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKYIV-RDNGERIDLRFHPKS--SDL 430
            ||.||..||:.|||||.||..|...:|:.:|.|...:|||.|:: |::|.:..|||..::  :|
pombe   373 QVAVPYRIAKILTFPERVTTQNKKHLQDCIRNGPDVHPGANYVIDRESGFKRFLRFGNRNRIAD- 436

  Fly   431 HLQCGYKVERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLPWSTFRMNLSCTSPYNADFDGDEMNL 495
            .|:.|..|||||.|:|:|:|||||:|||:|:|.|.|||.||.|.|.|.....|||||||||||||
pombe   437 DLKIGDIVERHLHDNDVVLFNRQPSLHKLSIMAHLVKVRPWRTLRFNECVCGPYNADFDGDEMNL 501

  Fly   496 HVPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVFITREQVMNLLMFLP 560
            ||||:.|.:.|...:......:::|:..:|::...||.:||...::.:|.|:.|:.:.|:..::
pombe   502 HVPQTEEAKTEALELMGIKNNLVSPRNGEPIIAATQDFITAAYLLSLKDTFLDRKSISNICCYM- 565

  Fly   561 TWDAK----MPQPCILKPRPLWTGKQIFSLIIPGN------VNM---IRTHSTHPDEEDEGPYKW 612
             .||.    :|.|.|:|||.||||||:|::::..|      ||:   .|:.|....:..|
pombe   566 -MDASTHIDLPPPAIIKPRCLWTGKQVFTVLMKPNRFSKVLVNLDAKTRSFSRIKSKTPE----- 624

  Fly   613 ISPGDTKVMVEHGELIMGILCKKSLGT-SAGSLLHICFLELG-----------HDIAGRFYGNIQ 665
            :.|.|..:|:.:.|:|.|::.|..:|. ...||.::...:.|           ..:..||.||
pombe   625 MCPKDGYLMIRNSEIIAGVVDKSVVGDGKKDSLFYVILRDYGALEAAEAITRLSKMCARFLGN-- 687

  Fly   666 TVINNWLLFEGHSIGIGDTIADPQTYNEIQQAIKKA---KDDVINVIQKAHNMELEPTPGNTLRQ 727
                     .|.||||.|........::.:..:.||   .||.|  :|.|..: ||..||.....
pombe   688 ---------RGFSIGIEDVQPGKSLSSQKEILVNKAYATSDDFI--MQYAKGI-LECQPGMDQEA 740

  Fly   728 TFENKVNRILNDARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINISQVIACVGQQNVEGKRIPY 792
            |.|.|::..|:..||..|......|...|:...|...|||||.||:||::||||||.:.|||:|.
pombe   741 TLEAKISSTLSKVRDDVGEICMDELGPANSPLIMATCGSKGSKINVSQMVACVGQQIISGKRVPD 805

  Fly   793 GFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETGYIQRRLI 857
            ||:.|:||||.|:...|.::|||.||:.:||||:||.|||:.|||||:|||||||||||:.|||:
pombe   806 GFQDRSLPHFHKNSKHPLAKGFVSNSFYSGLTPTEFLFHAISGREGLVDTAVKTAETGYMSRRLM 870

  Fly   858 KAMESVMVNYDGTVRNSVGQLIQLRYGEDGL-------CGELVEFQN--MPTVKLSNKSFEKRFK 913
            |::|.:...||||||:|...::|..||:|||       .|:.|||:.  :.:|.|:
pombe   871 KSLEDLSSAYDGTVRSSNSDVVQFVYGDDGLDPTYMEGDGQAVEFKRTWIHSVNLN--------- 926

  Fly   914 FDWSNERLMKKVFTDDVIKEMTDSSEAIQELEAEWDRLVSDRDSLRQIFPNGESKVVLPCNLQRM 978
            :|..:..::.....|.|.:.:.|                              .|.:..||  |.
pombe   927 YDRHDSAMLPYEIIDYVNRALDD------------------------------PKFLTNCN--RD 959

  Fly   979 IWNVQKIFHINKRLPTDLSPIRVIKGVKTLLERCVIVTGNDRISKQANENATLLFQCLIRSTLCT 1043
            .....:.|.| :.:...|:.:|..:.:..:||...:   :|....:.:|.|.:..:
pombe   960 FIETIRTFVI-ENIAKYLASVRERRDLAPMLEEPDM---DDLDDMEGDEFAPVAKR--------- 1011

  Fly  1044 KYVSEEFRLSTEAFEWLVGEIETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKN 1108
            |.|....|::.:.....|.....::.:|:..||..|||:.|||:|||.|||||.|||||||:::
pombe  1012 KSVENIIRVTEKQLRSFVDRCWEKYMRAKVEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVAAQ- 1075

  Fly  1109 VTLGVPRLKEIINISKKPKAPSLTVFLTGGAARDAEKAKNVLCRLEHTTLRKVTANTAIYYDPDP 1173
            .||||||:|||||.:|....|.:|..|...  ||...|:.|..|:|.|.|:.||:.....|.|
pombe  1076 TTLGVPRIKEIINAAKTISTPIITGQLIND--RDERSARVVKGRIEKTYLKDVTSYIEEVYGP-- 1136

  Fly  1174 QRTVISEDQEFVNVYYEMP-DFDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINVGFGEDLNC 1237
                       |..|..:. :||.      :.:::||        :|:..||..|
pombe  1137 -----------VTTYLSIQVNFDT------ISKLQLD--------ITLADIAAAI---------- 1166

  Fly  1238 IFNDDNADKLVL------------RIRIMNNEENKFQDEDEAVDKMEDDMFLRCIEANMLSDMTL 1290
                .|..||.:            :|.:..:.:.| ..|.|...:::       ....:|.|:.:
pombe  1167 ----WNTPKLKIPSQQVTVNNTLQQIHVHTSSDGK-SSETEVYYRLQ-------TYKRVLPDVVV 1219

  Fly  1291 QGIEAIGKVYMHLPQTDSKKRIVITETGEFKAIGEWLLETDGTSMMKVLSERDVDPIRTSSNDIC 1355
            .||..|            .:.::..|:|:.:      |..:||.:..|::...:...:||:|.:.
pombe  1220 AGIPTI------------NRSVINQESGKIE------LFMEGTGLQAVMNTEGIVGTKTSTNHVM 1266

  Fly  1356 EIFQVLGIEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINRQDTGALM 1420
            |:..||||||.|.|:..|:...:..:||.|:.||:.||.||||.||.::.|||.|:.:.....|.
pombe  1267 EMKDVLGIEAARYSIISEIGYTMAKHGLTVDPRHIMLLGDVMTCKGEVLGITRFGVAKMKDSVLA 1331

  Fly  1421 RCSFEETVDVLMDAAAHAETDPMRGVSENIIMGQLPKMGTGCFDLLLDAEK 1471
            ..|||:|.|.|.:|||....|.:.|:||.|::|:|..:||..|.|:...|:
pombe  1332 LASFEKTTDHLFNAAARFAKDSIEGISECIVLGKLAPIGTNVFQLIRRTEE 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII215	NP_511124.1	PRK08566	14..887	CDD:236292	350/925 (38%)
		RNAP_II_RPB1_N	15..868	CDD:259848	340/905 (38%)
		RNA_pol_Rpb1_5	822..1420	CDD:282807	179/619 (29%)
		RNA_pol_Rpb1_6	890..1071	CDD:282801	27/182 (15%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	132/430 (31%)
		TCRP1	1602..1880	CDD:291605
		RCR	<1789..1864	CDD:304939
rpc1	NP_595506.1	PRK08566	8..917	CDD:236292	358/948 (38%)
		RNAP_III_RPC1_N	22..885	CDD:259847	339/901 (38%)
		RNA_pol_Rpb1_5	835..1326	CDD:282807	179/614 (29%)
		RNAP_III_Rpc1_C	1035..1374	CDD:132723	128/408 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710