DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RpII215 and Polr1a

DIOPT Version :9

Sequence 1:NP_511124.1 Gene:RpII215 / 32100 FlyBaseID:FBgn0003277 Length:1887 Species:Drosophila melanogaster
Sequence 2:NP_033114.3 Gene:Polr1a / 20019 MGIID:1096397 Length:1717 Species:Mus musculus


Alignment Length:1789 Identity:464/1789 - (25%)
Similarity:746/1789 - (41%) Gaps:417/1789 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PLRQVKRVQFGILSPDEIRRMSVTE-GGVQFAETMEGGRPKLGGLMDPRQGVIDRTSRCQTCAGN 73
            |.|:::.:.||:.|.:|::::||.. ...::.:.:  |.|...||.|...|..|....|.||..:
Mouse     8 PWRRLQGISFGMYSAEELKKLSVKSITNPRYVDYL--GNPSANGLYDLALGPADSKEVCATCVQD 70

  Fly    74 MTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPHNPKIKEIVMKSRGQPRKRLA 138
            ...|.||.|||||...|::.....|...:||..|..| .||..| ...|..::.:.|......|.
Mouse    71 FNNCSGHLGHIDLPLTVYNPFLFDKLYLLLRGSCLSC-HMLTCP-RAAIYLLISQLRVLEVGALQ 133

  Fly   139 YVYDLCK--GKTICEGGEDMDLTKENQQPDPNKKPGH----GGCGHYQPSIRRTGLDLTAE-WK- 195
            .||:|.:  .:.:.|.|:......:.:..:...|...    |..|.:..::..:...|.|: || 
Mouse   134 AVYELERILSRFLEETGDPSAFEIQEELEEYTSKILQNNLLGSQGTHVKNVCESRSKLVAQFWKT 198

  Fly   196 ---------------------------------HQNEDSQ-------------------EKKIVV 208
                                             |:..|.:                   .|:..:
Mouse   199 HMAAKQCPHCKTGRSVVRKEHNSKLIITYPATVHKKSDQEGTELPEGVPEAPGIDKAQMGKRGYL 263

  Fly   209 SAERVWEILKHITDEECFIL-----GMD---PKYA-RPDWMIVTVLPVPPLAVRPA--------- 255
            :.....|.|..|...|.|.|     |:|   |:.: .|....:..:.|||...||.         
Mouse   264 TPSSAQEHLFAIWKNEGFFLNYLFSGLDDIGPESSFNPSMFFLDFIVVPPSRYRPVNRLGDQMFT 328

  Fly   256 ---VVMFGAAKNQDDLTHKLSDIIKANNEL----------RKNEAS------------GAAAHVI 295
               .|...|......|..||..::....:|          ::|::|            |.:....
Mouse   329 NGQTVNLQAVMKDAVLIRKLLALMAQEQKLPCEMTELTIDKENDSSVAIDRSFLGLLPGPSLTDK 393

  Fly   296 QENIKM-LQFHVATLVDNDM--------PGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRV 351
            ..||.: ||.||..:.|::|        ||:.:.::|              |||..|.::|||||
Mouse   394 LYNIWIRLQSHVNIVFDSEMDKLMLEKYPGIRQILEK--------------KEGLFRKHMMGKRV 444

  Fly   352 DFSARTVITPDPNLRIDQVGVPRSIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKYIVRDNG 416
            |::||:||.||..:..:::|:|...|..||:|:.|||:|:..:::.|..|.:.:|||..::.::|
Mouse   445 DYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINEDG 509

  Fly   417 ERIDLRF-------------------HPKSSDLHLQCGYKVERHLRDDDLVIFNRQPTLHKMSMM 462
            .|..|..                   .||.....:.|     ||:::.|:::.|||||||:.|:.
Mouse   510 SRTALSSVDAAQREAVAKQLLTPATGAPKPQGTKVVC-----RHVKNGDILLLNRQPTLHRPSIQ 569

  Fly   463 GHRVKVLP-WSTFRMNLSCTSPYNADFDGDEMNLHVPQSMETRAEVENIHITPRQIITPQANKPV 526
            .||.::|| ....|::.:....|||||||||||.|.|||...|||...:..|.:|.:.|:..:|:
Mouse   570 AHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPL 634

  Fly   527 MGIVQDTLTAVRKMTKRDVFITREQVMNLLMFLPTWD----AKMPQPCILKPRPLWTGKQIFSLI 587
            .|::||.:.:...||.|..|.||||.|. |::....|    .|:..|.||||.|||||||:.|.:
Mouse   635 AGLIQDHMVSGANMTIRGCFFTREQYME-LVYRGLTDKVGRVKLFPPAILKPFPLWTGKQVVSTL 698

  Fly   588 IPGNVNMIRTHSTHPDEEDEGPYK-----------WI-------------SPGDTKVMVEHGELI 628
            :   :|:|        .||..|..           |:             |..:::|::..|||:
Mouse   699 L---INII--------PEDYAPLNLSGKAKIGSKAWVKEKPRPIPDFDPDSMCESQVIIREGELL 752

  Fly   629 MGILCKKSLGTSAGSLLHICFLELGHDIAGRFYGNIQTVINNWL-LFEGHSIGIGDTIADPQTYN 692
            .|:|.|...|:||..|:|.|:...|.:.:||....:..:...:| |:.|.::|:.|.:..|....
Mouse   753 CGVLDKAHYGSSAYGLVHCCYEIYGGETSGRVLTCLARLFTAYLQLYRGFTLGVEDILVKPNADV 817

  Fly   693 EIQ-----------QAIKKAK--------DDVINVIQKAHNMELEPTPGNTLRQTFENKVNRILN 738
            ..|           ||:|.|.        |::....|.|| :..:....|.:...|:.:||...|
Mouse   818 VRQRIIEESTQCGPQAVKAALSLPETASCDEIQGKWQDAH-LSKDQRDFNMIDMKFKEEVNHYSN 881

  Fly   739 DARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINISQVIACVGQQNVEGKRIPYGFRKRTLPHFI 803
            :................|||:.||.||:|||.:|..|:...:||..:||:|.|.....::||.|.
Mouse   882 EINKACMPLGLHRQFPENNLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFE 946

  Fly   804 KDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVNYD 868
            ..::.|.:.|||...:|.|:.|.||:||.|.|||||:||||||:.:||:||.:||.:|.:::.||
Mouse   947 PYEFTPRAGGFVTGRFLTGIRPPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVIQYD 1011

  Fly   869 GTVRNSVGQLIQLRYGEDGLCGELVEFQNMPTVKLSNKSFEKRFKFDWSN-ERLMKKVFTDDVIK 932
            .|||:|.|.::|..||||||        ::|..:...   .|:|.|...| |.:||.....:|:.
Mouse  1012 LTVRDSDGSVVQFLYGEDGL--------DIPKTQFLQ---PKQFPFLAGNYEVIMKSKHLHEVLS 1065

  Fly   933 EMTDSSEAIQELEA--EWDRLVSDRDSLRQIFPNGESKVVLPCNLQRMIWNVQKIFHINKRLPTD 995
            . .|..:.:..::|  :|....|.....:..|.:...|:........:..::|     |.|.|. 
Mouse  1066 R-ADPQKVLGHIKAIKKWHHKHSGALLRKGAFLSFSQKIQAAVKALNLKGSIQ-----NGRSPE- 1123

  Fly   996 LSPIRVIKGVKTLLERCVIVTGNDRISKQAN----ENATLLFQCLIRSTLCTKYVSEEFRLSTEA 1056
                     .:.:|:....:....|...|..    .:.:|   .:.|..:....|||.|....:.
Mouse  1124 ---------TQQMLQMWYDLDEESRWKYQKRAAPCPDPSL---SVWRPDIYFASVSETFEKKIDD 1176

  Fly  1057 F--EW-----------------LVGEIETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFA 1102
            |  ||                 |...::.::|::..:|||.||.|||||:|||:|||||||||||
Mouse  1177 FSQEWAAQAERSYKKSELSLDRLRTLLQLKWQRSLCDPGEAVGLLAAQSIGEPSTQMTLNTFHFA 1241

  Fly  1103 GVSSKNVTLGVPRLKEIINI-SKKPKAP--SLTVFLTGGAARDAEKAKNVLCRLEHTTLRKVTAN 1164
            |....|||||:|||:||:.: |...|.|  |:.||.|..|.:   |.|::..||....|.:|.  
Mouse  1242 GRGEMNVTLGIPRLREILMVASANIKTPMMSVPVFDTKKALK---KVKSLKKRLTRVCLGEVL-- 1301

  Fly  1165 TAIYYDPDPQRTVISED-----------------QEFVNVYYEM-----PD----FDPTRISPWL 1203
                     |:..|.|.                 |...:.||:.     |:    |..||....|
Mouse  1302 ---------QKVDIQESFCMGEKRNKFQVYELRFQFLPHAYYQQEKCLRPEDILHFMETRFFKLL 1357

  Fly  1204 LRI------------ELDRKRMTDKKLT-------MEQIAEKINVGFGEDLNCIFNDDNADKLVL 1249
            :..            .::.:|.|.|.|.       .::..|:.....|..::....:.:||....
Mouse  1358 MEAIKKKKNKASAFRNVNSRRATQKDLNDTEDSGRSQREEERDEEEEGNIVDAEAEEGDADASDT 1422

  Fly  1250 RIRIMNNEENKFQDEDEAVDKMEDDMFLRCIEANMLSDMTLQGIEAIGKVYMHLPQTDS------ 1308
            :.:....||..::.|:|..::.|:::   ..|.|:..|...||.|...:.::.|.:.:|      
Mouse  1423 KRKEKQEEEVDYESEEEGEEEEEEEV---QEEGNIKGDGVHQGHEPDEEEHLGLEEEESSQKPPR 1484

  Fly  1309 -----------KKRI-------------------------------------------------- 1312
                       |:||                                                  
Mouse  1485 RHSRPQGAEAIKRRIQAVRESYSFIEDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHKAI 1549

  Fly  1313 ----------VITETGEFKAIGEWLLETDGTSMMKVLSERDV-DPIRTSSNDICEIFQVLGIEAV 1366
                      ::.||...|...|.:|.|:|.::.::....:: |..|..||||..:....||||.
Mouse  1550 VYTTKGITRCLLNETTNSKNEKELVLNTEGINLPELFKYSEILDLRRLYSNDIHAMANTYGIEAA 1614

  Fly  1367 RKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINRQDTGALMRCSFEETVDVL 1431
            .:.:|||:..|...||:.|:.|||:|:.|.|..:|....:.|.|| :..:..|.:.:||.:...|
Mouse  1615 LRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGI-QSSSSPLQQMTFETSFQFL 1678

  Fly  1432 MDAAAHAETDPMRGVSENIIMGQLPKMGTGCFDL 1465
            ..|......|.::..|..:::|::.|.|||.|:|
Mouse  1679 KQATMMGSHDELKSPSACLVVGKVVKGGTGLFEL 1712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpII215NP_511124.1 PRK08566 14..887 CDD:236292 294/1053 (28%)
RNAP_II_RPB1_N 15..868 CDD:259848 283/1033 (27%)
RNA_pol_Rpb1_5 822..1420 CDD:282807 190/749 (25%)
RNA_pol_Rpb1_6 890..1071 CDD:282801 33/206 (16%)
RNAP_II_Rpb1_C 1050..1468 CDD:132720 138/561 (25%)
TCRP1 1602..1880 CDD:291605
RCR <1789..1864 CDD:304939
Polr1aNP_033114.3 RNA_pol_rpoA1 10..1038 CDD:274106 299/1071 (28%)
RNAP_I_RPA1_N 16..1011 CDD:259844 283/1030 (27%)
RNA_pol_Rpb1_5 965..1668 CDD:282807 191/750 (25%)
Bridging helix. /evidence=ECO:0000250 968..980 7/11 (64%)
RNAP_I_Rpa1_C 1206..1713 CDD:132722 133/525 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1372..1493 21/123 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0086
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D591636at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.