DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII215 and rpc-1

DIOPT Version :9

Sequence 1:	NP_511124.1	Gene:	RpII215 / 32100	FlyBaseID:	FBgn0003277	Length:	1887	Species:	Drosophila melanogaster
Sequence 2:	NP_501127.2	Gene:	rpc-1 / 177491	WormBaseID:	WBGene00004411	Length:	1400	Species:	Caenorhabditis elegans

Alignment Length:	1525	Identity:	509/1525 - (33%)
Similarity:	772/1525 - (50%)	Gaps:	248/1525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GVQFA---------------------ETMEGG-RPKLGGLMDPRQGVIDRTSRCQTCAGNMTECP 78
            ||:||                     |.:||. :|...|.:||:.||..:|..|.||...:|:|.
Worm    17 GVKFAPGDCEFMRQTAHVPIFNNKLYEDVEGKLQPANYGPLDPKMGVSTKTGTCSTCGLGLTDCV 81

  Fly    79 GHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPH----------NPKIKEIVMKSRGQP 133
            ||||:.||..|||||||...||::|:|:|..||.:|::|.          ||.:..:..|:.
Worm    82 GHFGYFDLDVPVFHIGFFKLTIQLLQCICKNCSSILLTPEQHRVFSRQVMNPNLDYLHRKAL--- 143

  Fly   134 RKRLAYVYDLCKGKTICEGGEDMDLTKENQQPDPNKKPGHGGCGHYQPSIRR------------- 185
            .||:...   ||..:.|                     .|  ||....::::
Worm   144 HKRIVAA---CKKGSTC---------------------SH--CGLKNGTVKKAVGAVLKIAFASP 182

  Fly   186 TGLDLTAEWKHQNEDSQE--------KKIVVSAERVWEILKHITDEECFILGM---DPKYARPDW 239
            ..:|...::......:||        |..:::...|.::..:|.:.:..:|.:   :.|:  |:.
Worm   183 VSVDELGKFATMFSSNQEVGDHVRKMKFTLLNPLFVQKLFSNIKEGDIPVLMVRSGEEKH--PND 245

  Fly   240 MIVTVLPVPPLAVRPAVVM-FGAAKNQDDLTHKLSDIIKANNELRKNEASGAAAHVIQENIKMLQ 303
            :::|.:||||:.:||:||. ..|...:||:|.||.:|:..|:.|:|::..||.:..:.|..:.||
Worm   246 LLLTRMPVPPVCIRPSVVSEVKAGTTEDDVTMKLMEIMLTNDVLKKHKRDGAPSKTLFETWEHLQ 310

  Fly   304 FHVATLVDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRID 368
            ...|..::::|.|:|..||.. :.::|...|||||:||.||||.|||||||.||||:||||||||
Worm   311 IQCALYINSEMSGLPPDMQPK-RAMRAFTQRLKGKQGRFRGNLCGKRVDFSGRTVISPDPNLRID 374

  Fly   369 QVGVPRSIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKYIVRDNGERIDLRFHPKSSDL--H 431
            |||||..:|..|||||:|...||::|::||..|:..:|||.|:|........|..:.|..:|  :
Worm   375 QVGVPIHVAMTLTFPEIVNASNIEKMRQLVINGSDVHPGANYLVEKKTGNKKLLKYGKRDELAKN 439

  Fly   432 LQCGYKVERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLPWSTFRMNLSCTSPYNADFDGDEMNLH 496
            |:.|..:||||.|:|:|:|||||:|||:|:|.||.||:|..|||.|....:||||||||||||||
Worm   440 LRMGDTIERHLDDNDVVLFNRQPSLHKISIMSHRAKVMPGRTFRFNECACTPYNADFDGDEMNLH 504

  Fly   497 VPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVFITREQVMNLLMFLPT 561
            :||:.|.:||...:......:|||::.:|::..:||.:|....:|.:|.|:.|.:|......|..
Worm   505 LPQTYEAKAEASELMNVKNNLITPRSGEPLVAAIQDFITGGYLLTHKDTFLPRAEVYRFAAALID 569

  Fly   562 WDAK------MPQPCILKPRPLWTGKQIFSLII-PGNVNMIRTHSTHPDEEDEGPYKWISPGDTK 619
            ..||      :|.|.|.:|..||||||:..||| |...:.:..:.|..::...|..:..|. |:.
Worm   570 ASAKKQTKIRIPPPAIRRPVELWTGKQLIELIIRPDKGSDVSLNLTAKNKSYTGNLELCSK-DSY 633

  Fly   620 VMVEHGELIMGILCKKSLGTSAG-SLLHICFLELGHDIAGRFYGNIQTVINNWLLFEGHSIGIGD 683
            |::.:..|:.|.|.|..||:|:. ::.::...:.|.|.|......:..:...:|...|.||||||
Worm   634 VIIRNSVLLAGCLDKSLLGSSSKVNIFYMLMRDYGEDAAVDAMWRLARMAPVFLSNRGFSIGIGD 698

  Fly   684 TIADPQTYNEIQQAIKKAKDDVINVIQKAHNMELEPTPGNTLRQTFENKVNRILNDARDKTGGSA 748
            .....|...|..|.:..........|::....:|:..||.|..:|.|:.:.|.|:..||..|...
Worm   699 VRPSEQLLREKGQLVDNGYSKCSQYIKELEEGKLKAQPGCTEEETLESIILRELSTIRDHAGQVC 763

  Fly   749 KKSLTEYNNLKAMVVSGSKGSNINISQVIACVGQQNVEGKRIPYGFRKRTLPHFIKDDYGPESRG 813
            .::|::||....|.|.|||||.|||||:|||||||.:.|.|.|.||.:|:||||.:....||::|
Worm   764 LRNLSKYNAPLTMAVCGSKGSFINISQMIACVGQQAISGHRPPDGFEERSLPHFERKKKTPEAKG 828

  Fly   814 FVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVNYDGTVRNSVGQL 878
            ||.||:.:||||:||:||.|||||||:|||||||||||:||||:|.:|.:..:||||||:|||.:
Worm   829 FVANSFYSGLTPTEFFFHTMGGREGLVDTAVKTAETGYMQRRLVKCLEDLCASYDGTVRSSVGDV 893

  Fly   879 IQLRYGEDGL--------CGELVEF-------QNMPTVKLSNKSFEKRFKFDWSNERL---MKKV 925
            |:..:|||||        .|.:|:|       :|:.|.|      |:....|..:|.|   ::|.
Worm   894 IEFVFGEDGLDPAMMEAKDGSVVDFTHVLEHAKNIQTTK------EQPIPVDKLDEVLKAEIQKK 952

  Fly   926 FTDDVIKEMTDSSEAIQELE----AEWDRLVSDRDSLRQIFPNGESKVVLPCNLQRMIWNVQKIF 986
            |....:......||.|.:.|    .:|.              ||::
Worm   953 FKGKYVHFADKLSEYITQTEIKKSKKWQ--------------NGKA------------------- 984

  Fly   987 HINKRLPTDLSPIRVIKGVKTLLERCVIVTGNDRISKQANENATLLFQCLIRSTLCTKYVSEEFR 1051
            |.......||......|..|.|               :|.:.:.|...||.::.||:
Worm   985 HCGNHETADLKTKESCKICKNL---------------EAYKTSLLANSCLTKTQLCS-------- 1026

  Fly  1052 LSTEAFEWLVGEIETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKNVTLGVPRL 1116
                    .:.....:..:|...||..|||:||.|:|||:|||||.|||||||:|.|:|.||||:
Worm  1027 --------FIELCYYKVARAITEPGTAVGAIAATSIGEPSTQMTLKTFHFAGVASMNITQGVPRI 1083

  Fly  1117 KEIINISKKPKAPSLTVFLTGGAARDAEKAKNVLCRLEHTTLRKVTANTAIYYDPDPQRTVISED 1181
            |||||..|....|.:|..|..  ..|...|:.|..|:|.|||.::.
Worm  1084 KEIINAVKTISTPIITAALLD--PYDESLARRVKARIEKTTLGEIC------------------- 1127

  Fly  1182 QEFVNVYYEMPDFDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINVGFGEDLNCIFNDDNADK 1246
             :::...| :||       .:.|.::|:.||:  :.|.:|...|.|:........|        .
Worm  1128 -DYIEEVY-LPD-------DYFLLVKLNSKRI--RLLQLEVCMESISYAIATSKVC--------P 1173

  Fly  1247 LVLRIRIMNNEENKFQDEDEAVDKMEDDMFLRCIEANMLSDMTLQGIEAIGKVYMHLPQTDSKKR 1311
            .:...:|:.:.:........:..|:...|.::.::.: |:::.::||.::.:..:|   .|.||
Worm  1174 QMRGCKIVAHGKTMMAIRPPSTSKLSKTMTMQILKYS-LANVVVKGIPSVNRCVIH---ADEKK- 1233

  Fly  1312 IVITETGEFKAIGEWLLETDGTSMMKVLSERDVDPIRTSSNDICEIFQVLGIEAVRKSVEKEMNA 1376
                  |:|     :.|..:||....|||...|||.:|:.|:...:..||||||.|..:..|:.|
Worm  1234 ------GDF-----YSLLVEGTDFRSVLSSVGVDPRKTNFNNALVVADVLGIEAARSCIINEIIA 1287

  Fly  1377 VLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINRQDTGALMRCSFEETVDVLMDAAAHAETD 1441
            .:..:|:.::.||:.||.||||.:|.::.|||:|:.:.....|:..|||:|:|.|.:||..::.|
Worm  1288 TMDAHGIGLDRRHVMLLADVMTYRGEVLGITRNGLVKMKDSVLLLASFEKTMDHLFEAAFFSQRD 1352

  Fly  1442 PMRGVSENIIMGQLPKMGTGCFDLLLDAEK 1471
            .:.||||.||||....:|||.|.|:...:|
Worm  1353 VIHGVSECIIMGTPMTVGTGTFKLMQKYDK 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII215	NP_511124.1	PRK08566	14..887	CDD:236292	345/917 (38%)
		RNAP_II_RPB1_N	15..868	CDD:259848	333/898 (37%)
		RNA_pol_Rpb1_5	822..1420	CDD:282807	184/619 (30%)
		RNA_pol_Rpb1_6	890..1071	CDD:282801	31/194 (16%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	129/417 (31%)
		TCRP1	1602..1880	CDD:291605
		RCR	<1789..1864	CDD:304939
rpc-1	NP_501127.2	PRK08566	14..923	CDD:236292	351/938 (37%)
		RNAP_III_RPC1_N	26..887	CDD:259847	333/893 (37%)
		PRK04309	1019..1383	CDD:235277	133/436 (31%)
		RNAP_III_Rpc1_C	1034..1374	CDD:132723	127/395 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720