DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII215 and rpoa-1

DIOPT Version :9

Sequence 1:	NP_511124.1	Gene:	RpII215 / 32100	FlyBaseID:	FBgn0003277	Length:	1887	Species:	Drosophila melanogaster
Sequence 2:	NP_001022450.1	Gene:	rpoa-1 / 175015	WormBaseID:	WBGene00012999	Length:	1737	Species:	Caenorhabditis elegans

Alignment Length:	1798	Identity:	478/1798 - (26%)
Similarity:	734/1798 - (40%)	Gaps:	422/1798 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DSKAPLRQVKRVQFGILSPDEIRRMSVTEGGVQFAETM---EGGRPKLGGLMDPRQGVIDRTSRC 67
            :.:.|..|....:.....|.||.::||    ::..:|.   |.|.|..|||.||..|..:....|
Worm     7 NGEEPYMQFSNFKLRSYFPHEIDKLSV----LKITQTKTFDEVGHPIAGGLYDPILGPDNTFDMC 67

  Fly    68 QTCAGNMTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKM------------------- 113
            .||......||||.|||.||.|||:......|..:|:..|.:|.::
Worm    68 MTCNQYERHCPGHMGHIQLAVPVFNPLLFQFTYNLLKGSCVHCHRLTCKGDGVNARMLLAQLRCF 132

  Fly   114 ----------LVSPHNPKI-----------------------------------KEIVMKSRGQP 133
                      |.|....||                                   |.:..|:..|.
Worm   133 ELGVEHVAFDLESILRDKIANADLFGDDDSKTFNDVDACIAQLANKPLSELTAFKSMPTKNSVQL 197

  Fly   134 RKRLAYVY------------DLCKGK-----------------TICEGG----------EDMDLT 159
            :|.:...:            .|||.:                 :...||          .|....
Worm   198 KKDIITEFLRSHLFKRLQKCPLCKNRNGVLRNDGARSILIDFTSGARGGGKSKKAIIIIGDNGYN 262

  Fly   160 KENQQPDPNKKPGHGGCGHYQPSIRRTGLDLTAEWKHQNEDSQE--KKIVVSAE---RVW---EI 216
            :|:...:..:|.|.||.            ::|.:....:|.|.|  .|.|.:.|   ..|   |:
Worm   263 EESSTDEDEEKKGGGGA------------EVTGDVVDLDEGSLEMQMKNVRTGECDKLAWRGAEV 315

  Fly   217 LKH------------------ITDEECFILGMDPKYARPDWMIVTVLPVPPLAVRPAVVMFGAAK 263
            .:|                  :.||    |..:......|.:.:..:.|||...|| :.||..|:
Worm   316 REHFRMLFKNDGKLLLKLFPMLVDE----LNGEDMICPLDGLFLERILVPPKKFRP-IRMFKGAQ 375

  Fly   264 NQDDLTHKLSDIIKANNE------LRKNEASGAAAHVIQENIK-------------MLQFHVATL 309
            .:|..|..|..:::|...      :.|.:.|.....:|...::             .||.....:
Worm   376 YEDPQTLNLRKVLEATETISAISLIMKGDTSAQLKELIANRVRGKTINAQMHDAYLQLQLRANAI 440

  Fly   310 VDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRIDQVGVPR 374
            .|.|:....|      ..:..||..|:.|:|..|.::|||||:|:.|:||||||.|.||::|:|.
Worm   441 FDQDLNKGDR------DSIAGIKQILEKKQGLFRMHMMGKRVNFACRSVITPDPYLDIDEIGIPD 499

  Fly   375 SIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKYIVRDNGERIDLRFHPKSSDLHLQCGY--- 436
            ..|:.|||.|.|..||::.|:.|:|:|..|:|||.:.|..:|::..|...|:.....:|...
Worm   500 IFAKKLTFTEPVNAFNVNEMKGLLRQGPHQHPGANFFVEPSGKKTMLGDKPEEKKRRMQMAKTLN 564

  Fly   437 -----------KVERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLPWS-TFRMNLSCTSPYNADFD 489
                       ||.||:::.|:::.||||:|||.|::|||.:||... ..|||.:....||||||
Worm   565 AATTENLRQTPKVLRHMKNGDMIMMNRQPSLHKPSILGHRARVLTGQRALRMNYAPCKAYNADFD 629

  Fly   490 GDEMNLHVPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVFITREQVMN 554
            |||||.|:.||...:.||..|.......:.|:...|::|::||.:.:...::.||.|:.:|..|:
Worm   630 GDEMNGHLVQSHIAQTEVREIANVGSNFLVPKDATPLLGLIQDHVVSGVLLSVRDRFLNKEDFMH 694

  Fly   555 LLMFLPTWDAK---MPQPCILKPRPLWTGKQIFSLI----IPGNVNMIRTHSTHPDEEDEGPYK- 611
            |::......:|   :|.|.||.|:.||||||:.:.|    ||....:|..     |.:.:.|..
Worm   695 LVLASFAQYSKRIEIPPPTILYPKRLWTGKQVITTIVKNCIPDGKPLINL-----DGKAKTPLSC 754

  Fly   612 WISPG---------DTKVMVEHGELIMGILCKKSLGTSAGSLLHICFLELGHDIAGRFYGNIQTV 667
            ||.||         ::.|:...|||::|:|.|...|.:...|.|..|...||....:.......:
Worm   755 WIVPGFDAPQFDMSESHVVFRQGELLVGVLDKAHFGATQFGLAHCAFELYGHRCGVQLLSCFSRL 819

  Fly   668 INNWLLFEGHSIGIGDTIADPQTYNEIQQAIKKAKDDVINVIQKAHNMELEPTPG---NTLRQTF 729
            ...:|.|.|.::|:.|.:.......:.::|:.:::.....|::.|..:....||.   .||..|:
Worm   820 FTTYLQFHGFTLGVADILVVKDADGKRKEAVMESRTIGNQVVKTAFGLPDTATPAEIKRTLAATY 884

  Fly   730 EN--------------------KVNRILNDARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINIS 774
            .|                    |.|..:..:...||   ...|...|.|:.|:.||:|||.:|..
Worm   885 CNPRGQGTDVKMLDFGMKQGIAKYNDAITKSCVPTG---LLRLFPQNALQLMIQSGAKGSAVNAI 946

  Fly   775 QVIACVGQQNVEGKRIPYGFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGL 839
            |:..|:||..:||||:......||||.|...|..|.:.|:::..:|.|:.|.|.:||.|.|||||
Worm   947 QISGCLGQIELEGKRMAVTIAGRTLPSFRCFDPSPRAGGYIDQRFLTGMNPQELFFHTMAGREGL 1011

  Fly   840 IDTAVKTAETGYIQRRLIKAMESVMVNYDGTVRNSVGQLIQLRYGEDGLCGELVEFQNMPTVKLS 904
            |||||||:.:||:||.:||.:|.:.|:||.|||:..|.:||.||||||:......|.|..|:...
Worm  1012 IDTAVKTSRSGYLQRCIIKHLEGIRVHYDSTVRDHDGSVIQFRYGEDGMDTTKATFLNKKTMPFL 1076

  Fly   905 NKSFEKRFKFDWSNERLMKKVFTDDVIKEMTDSSEAIQELEAEWDRLVSDRDSLRQIFPNGESKV 969
            ..:.|              .|......:.:||:...|:|.|..:.::|..:....:...:|..|.
Worm  1077 EDNLE--------------AVTLASKPEGVTDADFGIKETEKRYKKIVKWKKKAEKSGKSGTKKS 1127

  Fly   970 VLPCNLQRMIWNVQKIFHINKRLPT---DLSPIRVIKGVKTLLERCVIVTGNDRISKQANE---- 1027
            .......   ::.:.|....||:..   :||          |.||.....|   |.|:..|
Worm  1128 YFSAFTN---FSAEHIGMEKKRILAMWFELS----------LEEREQYARG---IPKKCPEAVDE 1176

  Fly  1028 --NATLLFQCLIRSTL------CT---KYVSEEFRLSTEAFEWLVGEIETRFQQAQANPGEMVGA 1081
              |.|.....|....|      ||   |.|.:|    ....|.|...:..:..::.|:|||.||.
Worm  1177 RFNPTCKLGALPEKMLDEIEGFCTRRVKKVDDE----EPPKEVLKRTLYWKGMRSLADPGENVGL 1237

  Fly  1082 LAAQSLGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEII-NISKKPKAPSLTVFLTGGAARD--- 1142
            |||||:|||:||||||||||||....|||||:|||:||: ..||....||.::.:..|.:||
Worm  1238 LAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMTASKSIATPSASIAVIAGTSRDRID 1302

  Fly  1143 --------------------AEK---AKNVLCRLEHTTLRKVTANTAIYYDPDPQRTVISED--- 1181
                                .||   .:|..||..|..:..:.|..........:|:.|.|:
Worm  1303 SIKRELDRVYLKQLLKNFSLEEKITLTQNQSCRRYHLRIDILAAEKRELGARHLKRSQIMEEIEK 1367

  Fly  1182 -------QEFVNVYYEMPDFDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINVGFGEDLNCIF 1239
                   |.....|:|:.|:                ::|:.:.:....:|..|..| |.....:.
Worm  1368 RFILRVAQAIKKKYHEITDY----------------QQMSHRTMRQGNMAAGIETG-GTKNRGLQ 1415

  Fly  1240 NDDN-------------ADKLVLRIRIMNNEEN-----------KFQDEDEAVDKMEDDMFLRCI 1280
            ..||             ||....|:...:.:|.           :.::|:|.:|...:|:....:
Worm  1416 GPDNGDSSDEEADGGREADAAEARLHRRHRDEGADYEGEDEERVEVREEEEPMDSDSEDVKKEGL 1480

  Fly  1281 EAN-------MLSDMTLQGIEAIG----------------KVYMHLP------------------ 1304
            :..       :::...:|.::.:.                :|...||
Worm  1481 DGEDQTTEPLLVNSSRIQSVQRLSENISSYTYDVKSNKWCEVVFELPLRNKTKMDVSSIVEKEVE 1545

  Fly  1305 -----QTDSKKRIVITETGEFKAIGEW-LLETDGTSMMKVLSERDV-DPIRTSSNDICEIFQVLG 1362
                 ||...:|.|  ||.|.|...|. :|:|.|.::.......|| |.....|||:..|.:..|
Worm  1546 LFIVHQTPGIERCV--ETTEQKNGKEMTILQTQGVNLAAFFKHADVLDVNSVYSNDLNLILENYG 1608

  Fly  1363 IEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINRQDTGALMRCSFEET 1427
            :||..|::..|||.|...||:.|:.|||:|..|.||..|.:....| |.....:..|.:.:||.|
Worm  1609 VEACSKAITTEMNNVFAVYGIEVSKRHLSLTADYMTFTGQIQPFNR-GAMSSSSSPLQKMTFETT 1672

  Fly  1428 VDVLMDAAAHAETDPMRGVSENIIMGQLPKMGTGCFDLLLDAE 1470
            :..|.:|..|.|.|.:...|..::||.||:.|||.||||||.:
Worm  1673 MAFLREALLHGEEDNVNSPSARLVMGALPRGGTGSFDLLLDTK 1715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII215	NP_511124.1	PRK08566	14..887	CDD:236292	299/1078 (28%)
		RNAP_II_RPB1_N	15..868	CDD:259848	287/1058 (27%)
		RNA_pol_Rpb1_5	822..1420	CDD:282807	192/724 (27%)
		RNA_pol_Rpb1_6	890..1071	CDD:282801	36/198 (18%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	139/526 (26%)
		TCRP1	1602..1880	CDD:291605
		RCR	<1789..1864	CDD:304939
rpoa-1	NP_001022450.1	PRK14977	10..1713	CDD:184940	476/1791 (27%)
		RNAP_I_RPA1_N	23..1040	CDD:259844	287/1051 (27%)
		RNAP_I_Rpa1_C	1223..1711	CDD:132722	135/507 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920