Protein Alignment APBA2 and CG31342

DIOPT Version :10

• Sequence 1: NP_005494.2
• Gene: APBA2 / 321
• HGNCID: 579
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_001097763.1
• Gene: CG31342 / 41592
• FlyBaseID: FBgn0051342
• Length: 994
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 165/905 - (18%)
• Similarity: 278/905 - (30%)
• Gaps: 312/905 - (34%)

Human    16 HRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPE------EQECHNHSPD----- 69
            |:..|.|.|  :.|.|.....|              .|.:|||.      .|...|...|
  Fly   212 HQAPPAPPP--EPPTSPVPTTP--------------APPAPAPAAMSNTLTQHLLNMLSDPISTY 260

Human    70 GDSSSDYVNNTSEEEDY---DEGLPEEEEGITYYIRYCPEDDSYLEGM---DC----NGE--EYL 122
            .:..|:.|.:.|.:||.   :|  |..|:..|........||.||..:   .|    ||.  :.:
  Fly   261 SEQISESVESASGQEDVAVAEE--PPAEQPTTSDADLNLSDDEYLSPLLRKACMLTENGARVDVV 323

Human   123 AHSAHPVDTD---------ECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAH 178
            ..:...|..|         :|:..:                           |.|:...|:...
  Fly   324 VVTGQRVSADQVLNLEHILQCERLI---------------------------PRPQTSRSMSAG- 360

Human   179 DQEEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMTSIT 243
                    .|.|.......|.::..::.|.     ....|.:|              ::::..::
  Fly   361 --------AADKSKRPQRKPLQSQSSSAAP-----TNSADSQD--------------NITIIQVS 398

Human   244 SASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGFKPKTRTPE 308
            :.:.:..||.||..|:::..|                  .:...||.|.        ||:|...:
  Fly   399 NTANSGQEHPPELPPKNTTTA------------------EVFRFPEVKS--------KPQTNAKQ 437

Human   309 ERLKWPHE-------------------QV-------CNGLEQPRKQQRSDLNGPVDNNNIPETKK 347
            :.::..||                   ||       .|....|.||..|  ||  .::.:..|.|
  Fly   438 QPIQTHHEYKSNVQIIPSNASSSTSTIQVLGKQSSSSNPYTTPVKQSSS--NG--SSSQVSGTTK 498

Human   348 V-----ASFPSFVAVPGPCEP-----------------------EDLIDGIIFAANYLGSTQLL- 383
            |     ....:.|||.|.|.|                       ..|...||.:||..|.|.:.
  Fly   499 VKVLGDGDATTKVAVYGTCYPAAGGSAPSSSAASSSVNPAKPQTPRLSKKIILSANTSGITNISV 563

Human   384 -----SERNPSKNIRM----------MQAQEAVSRVKRMQKAAKI--------KKKANSEGDAQT 425
                 |:...|.||..          :.::.:.:||........:        :::..|...||.
  Fly   564 NTEQGSDSIISGNIHYEKVFLSSSIPITSRSSPTRVANTNTTQPVTNGSPALPRRRLASPATAQP 628

Human   426 LTE--------------VDLFISTQ-------RIKVLNADTQETMMDHALRTISYIADIGNIVVL 469
            :|.              .:|.||::       .:|:||... :|...|.    |..|...||
  Fly   629 VTPNAAGRATPQLTRGLTELVISSRPSRRDFHYLKLLNTPL-KTKTSHK----STSAANNNI--- 685

Human   470 MARRRMPRSASQDCIETTP-----------GAQEGKKQYKMICHVFESEDAQLIAQSIGQAF--- 520
                .....:|.:..:.||           .:||.:::..      .:.|||...|.:.|..
  Fly   686 ----EQSTPSSSNSTQVTPTQRNNTSIVTGDSQEQRRRSS------STSDAQAPLQRVPQPATQR 740

Human   521 SVAYQEFLRA-NG---------------INPEDLSQKEYSDIINTQEM-YNDDLIHFSNSENCKE 568
            :....||..: ||               .||...|..:...:...|.| ...:::|...
  Fly   741 NANNNEFTPSRNGAFRMQPPPQGTPPSSTNPAQQSPNKRLTLREQQVMQLRREIMHPGG------ 799

Human   569 LQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLAT 633
            ::|...:.:.:|.:    .|......|.:|.............|.||||::||.|.|:..  .|.
  Fly   800 VRLNLRRKDCVGSI----AWVEAFGGVWIAGWKQKEHPVLYNALHIGDQLLSIAGVSISS--AAE 858

Human   634 CQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNG---IICSLMRGGIAERGGVR 695
            ...||:. .|...|::.:...|......|:|......||. :::|   .|..::...:|.|.|:.
  Fly   859 ANKIIRN-TNTLFVEVLLRRIPFGRAYAIRRDREGQCLGL-IRDGNTSTIVDVVPNSLAARHGLP 921

Human   696 VGHR-----------IIEINGQSVVATAHEKIVQALSNSVG-EIHMKTMPAAMFRLLTGQ 743
            ...:           :.||||:|:.....:..::...|||| :|.:...|:.:...|..|
  Fly   922 PKTQSCDGNSLTFWMLTEINGRSLNLFFKDFEIRDRLNSVGRDISILVQPSDLITKLKKQ 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APBA2	NP_005494.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94		21/91 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..220		10/98 (10%)
		STXBP1-binding	185..270		12/84 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..344		23/131 (18%)
		PTB_X11	363..535	CDD:269919	44/269 (16%)
		PDZ1_APBA1_3-like	567..652	CDD:467203	19/84 (23%)
		PDZ2_APBA1_3-like	656..733	CDD:467255	19/91 (21%)
CG31342	NP_001097763.1	PHA03247	<589..785	CDD:223021	35/213 (16%)
		PDZ_canonical	<838..866	CDD:483948	12/30 (40%)
		PDZ_canonical	879..969	CDD:483948	20/90 (22%)