Protein Alignment APBA2 and X11L

DIOPT Version :10

• Sequence 1: NP_005494.2
• Gene: APBA2 / 321
• HGNCID: 579
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_001285376.1
• Gene: X11L / 252671
• FlyBaseID: FBgn0026313
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 904
• Identity: 332/904 - (36%)
• Similarity: 435/904 - (48%)
• Gaps: 247/904 - (27%)

Human    16 HRVRPGPVPHSQEP-----ESEDMELPLEGYVPEGLELAALRPESP----------APEEQECHN 65
            ||......|..|.|     |..|:||.::.......:||....|:.          :||..:..:
  Fly   344 HRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDS 408

Human    66 HSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEEYLAHSAHPVD 130
            :..|.||.|:.:|..::.......:|..|:|::                          |.|..|
  Fly   409 NCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLS--------------------------SGHASD 447

Human   131 TDECQEAVEEWTDSAGPHP-HGHEAEGSQ---DY---------------------PDGQLPI--- 167
            |:.....|.:...|:...| |.|...|.:   ||                     ....||:
  Fly   448 TENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPMPPA 512

Human   168 -PEDEPSVLEAHDQEE------------DGH----YCASKEGYQDYYPEEANGNTGASPYRLRRG 215
             |...|..:|..|..|            |.|    |.|:..|  .:..:.|....|.:|.   ..
  Fly   513 PPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGG--THTEKSAGSGLGVTPV---TA 572

Human   216 DGDLEDQ-EEDIDQIVAEIKMSLSM-----------------------------TSITSASEASP 250
            .|.|..| ..:|.:.:.||:.:|..                             |:|::|..|:.
  Fly   573 GGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAA 637

Human   251 EHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGFKPKTRTPEERLKWPH 315
            :..|:...|..                       .||.:.:|  |.|..|..::....
  Fly   638 DEEPDTDLETD-----------------------RLLGQQRH--DEQDFFADQSLADN------- 670

Human   316 EQVCNGLEQPRKQQRSDLNGPVDNNN-------IPETKKVA------------------------ 349
                |..|.........|||..||||       .|:|...|
  Fly   671 ----NANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTT 731

Human   350 ----SFP---SFVAVP-----------------------GPCEPEDLIDGIIFAANYLGSTQLLS 384
                |.|   .|...|                       |..||:.||:|::|.|.|||||||:.
  Fly   732 DISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLLEPKVLIEGVLFRARYLGSTQLVC 796

Human   385 ERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETM 449
            |..|:|:.|||||:|||||:|.:.          .||::|..|||||||||::|.|||.|.:|.|
  Fly   797 EGQPTKSTRMMQAEEAVSRIKALA----------PEGESQPSTEVDLFISTEKIMVLNTDLKEIM 851

Human   450 MDHALRTISYIADIGNIVVLMARRR-MPRSASQDCIET------TPGAQEGK-----------KQ 496
            |||||||||||||||::|||||||| :|.|.....|.:      |||..|.:           :.
  Fly   852 MDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRT 916

Human   497 YKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQK-EYSDIINTQEMYNDDLIHF 560
            .|||||||||::||.|||||||||.|||.|||:||||..|.|::: :|.:::|:||::.|:|..|
  Fly   917 PKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIF 981

Human   561 SNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTS 625
            :..|..||:.:.|.||||||||:|||||||:||||::||:|:.|.|||.|:|:||||:::|||.|
  Fly   982 AKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMS 1046

Human   626 LVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAE 690
            ||||||:|||..|:..||||.||..:|.||||..|.|.||...:|||||||||:||||:||||||
  Fly  1047 LVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAE 1111

Human   691 RGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI 749
            ||||||||||||||.|||||..|:.||:.||:|||||.|||||.:|||||||||||:||
  Fly  1112 RGGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APBA2	NP_005494.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94		20/92 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..220		26/134 (19%)
		STXBP1-binding	185..270		20/118 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..344		21/141 (15%)
		PTB_X11	363..535	CDD:269919	106/189 (56%)
		PDZ1_APBA1_3-like	567..652	CDD:467203	55/84 (65%)
		PDZ2_APBA1_3-like	656..733	CDD:467255	57/76 (75%)
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	105/188 (56%)
		PDZ1_APBA1_3-like	988..1071	CDD:467203	55/82 (67%)
		PDZ2_APBA1_3-like	1082..1154	CDD:467255	54/71 (76%)