DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drak and STK17A

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_004751.2	Gene:	STK17A / 9263	HGNCID:	11395	Length:	414	Species:	Homo sapiens

Alignment Length:	379	Identity:	152/379 - (40%)
Similarity:	214/379 - (56%)	Gaps:	52/379 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KGLLVSCPDINEIYEVEQT-PF------------ARGKFAAVRRAIHKNTGSHFAAKFLKRRRRA 74
            :|||      .||..|.:| ||            .|||||.||:.|.|::|..|||||:::||:.
Human    40 RGLL------TEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKG 98

  Fly    75 QSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGEL--QTILDNEECLTEAQA 137
            |....||.||||||.|.:....::||:.|:||.|:..|:||.|.|||:  |.:.|.||...|...
Human    99 QDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDV 163

  Fly   138 RHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPD 202
            :..||::|:.:.|||.|.:.|||||||||||..|.....:|:.|||:||::.....:||:.|||:
Human   164 QRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPE 228

  Fly   203 YVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPV 267
            |||||:|.|:|:|:.||:||:||||||:|:|.|||.|:.||||||||||..|::.:..|..:|..
Human   229 YVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293

  Fly   268 AIDFIRRALRIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEE-----------DV 321
            |:||||..|..||.||..|..||.|.||... |:.     :|....|:..||           ::
Human   294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQS-SIQ-----EPSFRMEKALEEANALQEGHSVPEI 352

  Fly   322 DDDVEDEEEEEQVEEEE--------------EETQNVEEPTTEAPQQQQQPVQQ 361
            :.|.:..|.:|.:..||              .|.:.:|:.......:.::|:.|
Human   353 NSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQ 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	133/281 (47%)
		S_TKc	45..295	CDD:214567	127/251 (51%)
		PHA03255	379..>554	CDD:165513
STK17A	NP_004751.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		152/379 (40%)
		STKc_DRAK1	51..321	CDD:271099	130/269 (48%)
		S_TKc	64..321	CDD:214567	127/256 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		2/20 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1996
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004726
OrthoInspector	1	1.000	-	-		otm40784
orthoMCL	1	0.900	-	-		OOG6_106249
Panther	1	1.100	-	-	LDO	PTHR24342
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4829
SonicParanoid	1	1.000	-	-		X3322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.940