DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and STK17B

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_004217.1	Gene:	STK17B / 9262	HGNCID:	11396	Length:	372	Species:	Homo sapiens

Alignment Length:	347	Identity:	129/347 - (37%)
Similarity:	197/347 - (56%)	Gaps:	20/347 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DADRLKGLLVSCPDI-------NEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQ 75
            |...:.|||.:.|.|       |..|.:......|||||.||:.|.|:||..:||||||:|||.|
Human     7 DCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQ 71

  Fly    76 SSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNE--ECLTEAQAR 138
            ....||.||||||.|.:....::||:.|:|..|:..|:||.|.|||:.::...|  |.::|....
Human    72 DCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVI 136

  Fly   139 HCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDY 203
            ..::::|:.:.:||..:|.|||||||||||:.......:|:.|||:||.:.....:||:.|||:|
Human   137 RLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEY 201

  Fly   204 VAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVA 268
            :|||:|.|:|::..||:|::|::.|:||:..|||.|:..|||:|||||..:.:.:..|..||.:|
Human   202 LAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLA 266

  Fly   269 IDFIRRALRIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQ 333
            .|||:..|...|..|..|..||.|.||:   ..|.:....|:..:...:.:  |..|...|::..
Human   267 TDFIQSLLVKNPEKRPTAEICLSHSWLQ---QWDFENLFHPEETSSSSQTQ--DHSVRSSEDKTS 326

  Fly   334 VEE------EEEETQNVEEPTT 349
            ...      :.|:.:|:.|.::
Human   327 KSSCNGTCGDREDKENIPEDSS 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	115/275 (42%)
		S_TKc	45..295	CDD:214567	111/251 (44%)
		PHA03255	379..>554	CDD:165513
STK17B	NP_004217.1	STKc_DRAK2	24..293	CDD:271100	113/268 (42%)
STK17B	NP_004217.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..362		6/46 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1996
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31231
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2515
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004726
OrthoInspector	1	1.000	-	-		otm40784
orthoMCL	1	0.900	-	-		OOG6_106249
Panther	1	1.100	-	-	O	PTHR24342
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4829
SonicParanoid	1	1.000	-	-		X3322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890