DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drak and PKH2

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_014541.1	Gene:	PKH2 / 854053	SGDID:	S000005460	Length:	1081	Species:	Saccharomyces cerevisiae

Alignment Length:	604	Identity:	130/604 - (21%)
Similarity:	224/604 - (37%)	Gaps:	131/604 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKH---EIAVLMLCEGEDNIVNLNAVHETR 107
            |.::.|..|...:|...:|||.|.:....:  .|::|:   |...|.......::|.|.:..:..
Yeast   188 GAYSTVMLATSIDTKKRYAAKVLNKEYLIR--QKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDE 250

  Fly   108 SDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGER 172
            |....|||.|..|:..:::.....|.|..||:...:::.|:.:||...|.|.|:||:||||.||.
Yeast   251 SSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEM 315

  Fly   173 IEDGLKLCDFGISRVVCEGIN------------VREMAGTPDYVAPEVLQYEPLSLLTDIWSVGV 225
               .:||.|||.::::....|            .:...||.:||:||:|.........|||:.|.
Yeast   316 ---KIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGC 377

  Fly   226 LTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAI-DFIRRALRIKPNDRMNATGC 289
            :.:.:::|..||....:..||..:.:....|....     |:.| |.:::.|....:.|:..:..
Yeast   378 ILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGF-----PLIIRDLVKKILVKNLDRRLTISQI 437

  Fly   290 LDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQVEEEEEETQNVEEPTTEAPQQ 354
            .:|.:.||....|..::                               .:....::.....|...
Yeast   438 KEHHFFKDLNFKDGSVW-------------------------------SKTPPEIKPYKINAKSM 471

  Fly   355 QQQPV-QQHQLAKSGQIHSKPTHNGHHRANSGGSISKIPIATSKLQSTPSSETTTAIHTLTSNSN 418
            |..|. ...:|.|                .|..::.|..:.|.:..|:||.|.||  |:...|:|
Yeast   472 QAMPSGSDRKLVK----------------KSVNTLGKSHLVTQRSASSPSVEETT--HSTLYNNN 518

  Fly   419 GHVHKPTQIVTPTRRASDSDKENTYTATFVKKPVATIQLGSSNGIEDATVVATLTLFPDAPTTPK 483
            .|....::| :..:|.:|   |.|          |.|...:..||.:.         .:.|.
Yeast   519 THASTESEI-SIKKRPTD---ERT----------AQILENARKGINNR---------KNQPG--- 557

  Fly   484 VIRKTPTGESNGSATSVKALVKK-FQLEDSSGSAVARRSGGAVTSSSGLHSPTTTSVRLNSIRRA 547
              ::||:|.::.:..:..||.|| .|...:|.|..:|.|..|.||..|.:..|:::        .
Yeast   558 --KRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSST--------E 612

  Fly   548 SEPLTTVYKKQTSQNGCSSTSNPSSSPGSSPTTSGSTATLLIHSQRLGNSTAP--------ASHC 604
            |:|.........|.........|.:.|.|.|.|...|..:          |.|        :...
Yeast   613 SKPFAKSPPLSASVLSSKVPMPPYTPPMSPPMTPYDTYQM----------TPPYTTKQQDYSDTA 667

  Fly   605 VAVPATATATSSASSSNSS 623
            :|.|....:..:..:|..|
Yeast   668 IAAPKPCISKQNVKNSTDS 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	67/264 (25%)
		S_TKc	45..295	CDD:214567	67/264 (25%)
		PHA03255	379..>554	CDD:165513	42/175 (24%)
PKH2	NP_014541.1	STKc_PDK1	177..443	CDD:270733	67/264 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I1285
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050