Protein Alignment Drak and MYLK2

DIOPT Version :10

• Sequence 1: NP_996411.2
• Gene: Drak / 32097
• FlyBaseID: FBgn0052666
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_149109.1
• Gene: MYLK2 / 85366
• HGNCID: 16243
• Length: 596
• Species: Homo sapiens
• Alignment Length: 261
• Identity: 96/261 - (36%)
• Similarity: 138/261 - (52%)
• Gaps: 21/261 - (8%)

  Fly    46 GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCE-----GEDNIVNLNAVHE 105
            |||.||...:.|.||...|||.:|::   ...|||:     ||:..|     ...|::.|.|..|
Human   294 GKFGAVCTCMEKATGLKLAAKVIKKQ---TPKDKEM-----VLLEIEVMNQLNHRNLIQLYAAIE 350

  Fly   106 TRSDTALLLELATGGEL-QTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNIL-- 167
            |..:..|.:|...|||| :.|:|.:..|||......:|::...:.|:|...:.||||||:|||
Human   351 TPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCV 415

  Fly   168 -LAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLL 231
             ..|..:    |:.|||::|.......::...|||::::|||:.|:.:|..||:||:||:||:||
Human   416 NTTGHLV----KIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLL 476

  Fly   232 SGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWLK 296
            ||.|||.||...||..|:......|.:..|..||..|.||:...:......||||..||.|.||.
Human   477 SGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLN 541

  Fly   297 D 297
            :
Human   542 N 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_996411.2	STKc_DRAK	28..295	CDD:271008	94/257 (37%)
		PHA03255	379..>554	CDD:165513
MYLK2	NP_149109.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..224
		STKc_MLCK2	280..540	CDD:271092	94/257 (37%)
		Calmodulin-binding. /evidence=ECO:0000250	574..586