DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and Kalrn

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_038944566.1	Gene:	Kalrn / 84009	RGDID:	621865	Length:	2989	Species:	Rattus norvegicus

Alignment Length:	266	Identity:	96/266 - (36%)
Similarity:	152/266 - (57%)	Gaps:	12/266 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGED 95
            ::|||        .||:|:.|::.|||.|....|.||:.::.:.:   ::..||.|:|...: ..
  Rat  2689 ELNEI--------GRGRFSIVKKCIHKATRKDVAVKFVSKKMKKK---EQAAHEAALLQHLQ-HP 2741

  Fly    96 NIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLD 160
            ..|.|:..:|:.:...|:|||...|.|...|.|.:.|.|.:....:|::::||::||:..:||||
  Rat  2742 QYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLD 2806

  Fly   161 LKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGV 225
            :||:|:|:........:||.|...:..:....::..:.|.|::.||||:|..|:||.|||||:||
  Rat  2807 IKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGV 2871

  Fly   226 LTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCL 290
            ||||:|||.|||..::|:||.:|:.:...:||...|.|||..|.|||...|:.....|..|..||
  Rat  2872 LTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCL 2936

  Fly   291 DHIWLK 296
            .|.||:
  Rat  2937 QHPWLQ 2942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	94/263 (36%)
		S_TKc	45..295	CDD:214567	91/249 (37%)
		PHA03255	379..>554	CDD:165513
Kalrn	XP_038944566.1	SEC14	42..180	CDD:214706
		SPEC	193..413	CDD:238103
		SPEC	314..539	CDD:238103
		SPEC	540..769	CDD:238103
		SPEC	894..1132	CDD:238103
		SPEC	1138..1238	CDD:197544
		RhoGEF	1287..1457	CDD:238091
		PH1_Kalirin_Trio_like	1464..1586	CDD:270060
		SH3_Kalirin_1	1652..1711	CDD:212786
		SH3-RhoG_link	1708..1892	CDD:406906
		RhoGEF	1935..2104	CDD:395496
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061
		SH3_Kalirin_2	2327..2385	CDD:212787
		Ig strand A	2466..2469	CDD:409353
		I-set	2474..2568	CDD:400151
		Ig strand A'	2482..2485	CDD:409353
		Ig strand B	2491..2498	CDD:409353
		Ig strand C	2504..2512	CDD:409353
		Ig strand C'	2515..2517	CDD:409353
		Ig strand D	2523..2532	CDD:409353
		Ig strand E	2534..2538	CDD:409353
		Ig strand F	2547..2555	CDD:409353
		Ig strand G	2558..2568	CDD:409353
		FN3	2572..2663	CDD:238020
		STKc_Kalirin_C	2693..2940	CDD:271017	92/258 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910