DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and CAMK4

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001310303.1	Gene:	CAMK4 / 814	HGNCID:	1464	Length:	473	Species:	Homo sapiens

Alignment Length:	453	Identity:	125/453 - (27%)
Similarity:	201/453 - (44%)	Gaps:	66/453 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VDADRLKGLLVSCPD----------INEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRR 71
            |.|....|.....||          :::.:||| :...||..:.|.|...|.|...:|.|.||:
Human    17 VTASAAPGTASLVPDYWIDGSNRDALSDFFEVE-SELGRGATSIVYRCKQKGTQKPYALKVLKK- 79

  Fly    72 RRAQSSDKEI-KHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEA 135
                :.||:| :.||.||:.. ...||:.|..:.||.::.:|:|||.|||||...:..:...:|.
Human    80 ----TVDKKIVRTEIGVLLRL-SHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSER 139

  Fly   136 QARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGT 200
            .|...::::|:|:.:||:..|.|.||||:|:|.|....:..||:.|||:|::|...:.::.:.||
Human   140 DAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGT 204

  Fly   201 PDYVAPEVLQ---YEPLSLLTDIWSVGVLTYVLLSGFSPF---GGDTKQETFLNISQCALTFPDN 259
            |.|.|||:|:   |.|   ..|:||||::||:||.||.||   .||  |..|..|..|...|...
Human   205 PGYCAPEILRGCAYGP---EVDMWSVGIITYILLCGFEPFYDERGD--QFMFRRILNCEYYFISP 264

  Fly   260 LFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWLKDDCS----LD-RQIYLQ----------- 308
            .:..||..|.|.:|:.:.:.|..|:.....|.|.|:....:    :| .|..||
Human   265 WWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAA 329

  Fly   309 -------------PQSDAEEEEEEDVDDD---VEDEEEEEQVEEEEEETQ-NVEEPTTEAPQQQQ 356
                         ..|....:|......|   ::|..|:.:...|.|:.| :..:...:..|.:.
Human   330 VKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAEL 394

  Fly   357 QPVQQHQLAKSGQIHSKPTHNGHHRANSGGSISKIPIATSKLQSTPSSETTTAIHTLTSNSNG 419
            ..||..:..|...|:::.......:|...|    |.:|..:|:...:.|....:....:...|
Human   395 MKVQALEKVKGADINAEEAPKMVPKAVEDG----IKVADLELEEGLAEEKLKTVEEAAAPREG 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	97/283 (34%)
		S_TKc	45..295	CDD:214567	92/256 (36%)
		PHA03255	379..>554	CDD:165513	7/41 (17%)
CAMK4	NP_001310303.1	STKc_CaMKIV	42..335	CDD:270987	100/304 (33%)
		Pkinase	46..300	CDD:278497	95/265 (36%)
		Autoinhibitory domain	305..321		4/15 (27%)
		PP2A-binding	306..323		4/16 (25%)
		Calmodulin-binding. /evidence=ECO:0000255	322..341		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..368		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..473		1/9 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910