DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and Dclk2

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001344389.1	Gene:	Dclk2 / 70762	MGIID:	1918012	Length:	772	Species:	Mus musculus

Alignment Length:	351	Identity:	103/351 - (29%)
Similarity:	165/351 - (47%)	Gaps:	36/351 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKE--IKHEIAVLMLCEGEDNIVNLNAVHETRS 108
            |.||.|:..:.:.||..||.|.:.   :|:...||  |::|:::|...: ..||:.|....||.:
Mouse   418 GNFAVVKECVDRYTGKEFALKIID---KAKCCGKEHLIENEVSILRRVK-HPNIIMLVEEMETAT 478

  Fly   109 DTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERI 173
            |..|::||..||:|...:.:....||......:..:..||::||..||.|.|:||:|:|:.  ..
Mouse   479 DLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVC--EY 541

  Fly   174 EDG---LKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFS 235
            .||   |||.|||::.|| || .:..:.|||.|||||::......|..|:|:.||:||:||.||.
Mouse   542 PDGTKSLKLGDFGLATVV-EG-PLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFP 604

  Fly   236 PFGGDT--KQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWLKDD 298
            ||..:.  :::.|..|....|.||...:..::..|.:.|.:.|::....|..|...|.|.|:.||
Mouse   605 PFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWVSDD 669

  Fly   299 CSLDRQIYLQ-------------PQSDAEEEEEEDVDDDVEDEEE--------EEQVEEEEEETQ 342
            .|.:..:..:             |:.::.......:.:...|:|.        ::......|:|.
Mouse   670 ASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKLCQDSSRPSREQTS 734

  Fly   343 NVEEPTTEAPQQQQQPVQQHQLAKSG 368
            .|.....|||...:.|......|.||
Mouse   735 PVPPSAQEAPPPLESPRPPGPPATSG 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	86/255 (34%)
		S_TKc	45..295	CDD:214567	86/255 (34%)
		PHA03255	379..>554	CDD:165513
Dclk2	NP_001344389.1	DCX	67..157	CDD:214711
		DCX	191..279	CDD:214711
		PKc_like	407..665	CDD:328722	86/254 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910