DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and STK33

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001275990.1	Gene:	STK33 / 65975	HGNCID:	14568	Length:	514	Species:	Homo sapiens

Alignment Length:	409	Identity:	109/409 - (26%)
Similarity:	194/409 - (47%)	Gaps:	54/409 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 INEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDN 96
            |.|||...:. ..:|.|..|..|..|.|.:.:|.|.:.:.:...|:.|.::.|:.:|...:.| :
Human   112 IEEIYTFGRI-LGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHE-H 174

  Fly    97 IVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDL 161
            |::|..|.||.....|::||...|||:.|||.:...:|.:.|..::.:..|:.:||:..|.|.||
Human   175 IIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDL 239

  Fly   162 KPQNILLAGERIED------GLKLCDFGIS-----------RVVCEGINVREMAGTPDYVAPEVL 209
            |.:||::....|:|      .:|:.|||::           :..|         |||.|:||||:
Human   240 KLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATC---------GTPIYMAPEVI 295

  Fly   210 QYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRR 274
            .....|...||||:||:.|:||.|..||...::::.|..|.:..|.|.:.::..:|..|...:::
Human   296 SAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQ 360

  Fly   275 ALRIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEE-----EDVDDDVEDEEEEEQV 334
            .:::.|..|:.|...||:.||..    ::...::|.:..|..:|     |.|:::..:|:.:...
Human   361 LMKVDPAHRITAKELLDNQWLTG----NKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPST 421

  Fly   335 EEEEEETQ---NVEEP--TTEAPQQQQQPVQQHQLAKSGQ-----IHSKPTHNGHHRANSGGSIS 389
            ||:.:..|   ||.:.  |::..:::|....:.|...:.:     ..|..|.:....|...|.:.
Human   422 EEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEME 486

  Fly   390 KIPIATSKLQSTPSSETTT 408
            |.|:       |||..|.|
Human   487 KTPV-------TPSQGTAT 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	82/279 (29%)
		S_TKc	45..295	CDD:214567	78/266 (29%)
		PHA03255	379..>554	CDD:165513	9/30 (30%)
STK33	NP_001275990.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..91
		STKc_STK33	114..381	CDD:270999	81/277 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..468		11/65 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..514		7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910