DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and Camk1

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_598687.1	Gene:	Camk1 / 52163	MGIID:	1098535	Length:	374	Species:	Mus musculus

Alignment Length:	299	Identity:	98/299 - (32%)
Similarity:	151/299 - (50%)	Gaps:	10/299 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VDADRLKGLLVSCPDINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEI 81
            |:..|.|    ...||.:||:.... ...|.|:.|..|..|.|....|.|.: .::..:..:..:
Mouse     5 VEGPRWK----QAEDIRDIYDFRDV-LGTGAFSEVILAEDKRTQKLVAIKCI-AKKALEGKEGSM 63

  Fly    82 KHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLK 146
            ::|||||...: ..|||.|:.::|:.....|:::|.:||||...:..:...||..|...:.:||.
Mouse    64 ENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLD 127

  Fly   147 ALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQY 211
            |:|:|||..|.|.||||:|:|......:..:.:.|||:|::...|..:....|||.|||||||..
Mouse   128 AVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ 192

  Fly   212 EPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRAL 276
            :|.|...|.||:||:.|:||.|:.||..:...:.|..|.:....|....:..:|..|.||||..:
Mouse   193 KPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLM 257

  Fly   277 RIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEE 315
            ...|..|......|.|.|:..|.:||:.|:   ||.:|:
Mouse   258 EKDPEKRFTCEQALQHPWIAGDTALDKNIH---QSVSEQ 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	87/266 (33%)
		S_TKc	45..295	CDD:214567	83/249 (33%)
		PHA03255	379..>554	CDD:165513
Camk1	NP_598687.1	STKc_CaMKI_alpha	16..278	CDD:271069	87/264 (33%)
		Autoinhibitory domain. /evidence=ECO:0000250	276..316		7/21 (33%)
		Calmodulin-binding. /evidence=ECO:0000250	296..317
		Nuclear export signal. /evidence=ECO:0000250	315..321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910