Protein Alignment Drak and MYLK

DIOPT Version :10

• Sequence 1: NP_996411.2
• Gene: Drak / 32097
• FlyBaseID: FBgn0052666
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: XP_024309300.1
• Gene: MYLK / 4638
• HGNCID: 7590
• Length: 1924
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 120/399 - (30%)
• Similarity: 198/399 - (49%)
• Gaps: 55/399 - (13%)

  Fly    32 INEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKE-IKHEIAVLMLCEGED 95
            :::.|::|:. ...|||..|.|.:.|.|...:|.||.|   ...:.:|| |:.||:: |.|....
Human  1470 VSDFYDIEER-LGSGKFGQVFRLVEKKTRKVWAGKFFK---AYSAKEKENIRQEISI-MNCLHHP 1529

  Fly    96 NIVNLNAVHETRSDTALLLELATGGEL-QTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHL 159
            .:|......|.:::..::||:.:|||| :.|:|.:..|||.:....||::.:.::::|.:.|.||
Human  1530 KLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHL 1594

  Fly   160 DLKPQNILL---AGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIW 221
            ||||:||:.   .|.||    ||.|||::|.:....:::.:.|||::|||||:.|||:...||:|
Human  1595 DLKPENIMCVNKTGTRI----KLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMW 1655

  Fly   222 SVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNA 286
            |:||:.|:|:||.|||.||...||..|::.....|.|..|..:|..|.|||...|:....:|::.
Human  1656 SIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC 1720

  Fly   287 TGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQVEEEEEETQNVEEPTTEA 351
            |.||.|.||              ..|.:..|.:.:.   :|..::.....:.::|.|.
Human  1721 TQCLQHPWL--------------MKDTKNMEAKKLS---KDRMKKYMARRKWQKTGNA------- 1761

  Fly   352 PQQQQQPVQQHQLAKSGQIHSKPTHNG-HHRANSGGSISKIPIATSKLQSTPSSETTTAIHTLTS 415
                        :...|::.|....:| ..|.:|.||.:. |:...||:|  ..:.:.|.....:
Human  1762 ------------VRAIGRLSSMAMISGLSGRKSSTGSPTS-PLNAEKLES--EEDVSQAFLEAVA 1811

  Fly   416 NSNGHVHKP 424
            ....|| ||
Human  1812 EEKPHV-KP 1819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_996411.2	STKc_DRAK	28..295	CDD:271008	97/267 (36%)
		PHA03255	379..>554	CDD:165513	13/46 (28%)
MYLK	XP_024309300.1	I-set	43..133	CDD:400151
		Ig strand B	60..64	CDD:409353
		Ig strand C	73..77	CDD:409353
		Ig strand E	99..103	CDD:409353
		Ig strand F	113..118	CDD:409353
		Ig strand G	126..129	CDD:409353
		I-set	171..260	CDD:400151
		Ig strand B	188..192	CDD:409353
		Ig strand C	201..205	CDD:409353
		Ig strand E	226..230	CDD:409353
		Ig strand F	240..245	CDD:409353
		Ig strand G	253..256	CDD:409353
		23ISL	261..422	CDD:435470
		I-set	424..514	CDD:400151
		Ig strand B	441..445	CDD:409543
		Ig strand C	454..458	CDD:409543
		Ig strand E	480..484	CDD:409543
		Ig strand F	494..499	CDD:409543
		Ig strand G	507..510	CDD:409543
		IgI_4_MYLK-like	523..610	CDD:409568
		Ig strand A	523..526	CDD:409568
		Ig strand A'	532..535	CDD:409568
		Ig strand B	540..548	CDD:409568
		Ig strand C	554..558	CDD:409568
		Ig strand C'	561..564	CDD:409568
		Ig strand D	568..572	CDD:409568
		Ig strand E	576..581	CDD:409568
		Ig strand F	589..597	CDD:409568
		Ig strand G	600..610	CDD:409568
		IgI_4_hemolin-like	633..722	CDD:409570
		Ig strand A	633..636	CDD:409570
		Ig strand A'	642..645	CDD:409570
		Ig strand B	650..657	CDD:409570
		Ig strand C	663..668	CDD:409570
		Ig strand C'	671..673	CDD:409570
		Ig strand D	678..682	CDD:409570
		Ig strand E	688..692	CDD:409570
		Ig strand F	701..709	CDD:409570
		Ig strand G	712..722	CDD:409570
		I-set	731..819	CDD:400151
		Ig strand B	748..752	CDD:409353
		Ig strand C	761..765	CDD:409353
		Ig strand E	787..791	CDD:409353
		Ig strand F	801..806	CDD:409353
		Ig strand G	814..817	CDD:409353
		I-set	1108..1197	CDD:400151
		Ig strand B	1125..1129	CDD:409353
		Ig strand C	1138..1142	CDD:409353
		Ig strand E	1163..1167	CDD:409353
		Ig strand F	1177..1182	CDD:409353
		Ig strand G	1190..1193	CDD:409353
		IgI_8_hMLCK_like	1247..1345	CDD:409419
		Ig strand A	1247..1251	CDD:409419
		Ig strand A'	1256..1260	CDD:409419
		Ig strand B	1264..1273	CDD:409419
		Ig strand C	1277..1283	CDD:409419
		Ig strand C'	1286..1288	CDD:409419
		Ig strand D	1294..1299	CDD:409419
		Ig strand E	1303..1308	CDD:409419
		Ig strand F	1316..1324	CDD:409419
		Ig strand G	1327..1337	CDD:409419
		FN3	1341..1433	CDD:238020
		STKc_MLCK1	1471..1729	CDD:271093	97/266 (36%)
		IgI_telokin-like	1822..1909	CDD:409565
Ig strand A	1822..1825	CDD:409565
Ig strand A'	1827..1830	CDD:409565
Ig strand B	1834..1843	CDD:409565
Ig strand C	1848..1854	CDD:409565
Ig strand C'	1857..1859	CDD:409565
Ig strand D	1865..1870	CDD:409565
Ig strand E	1873..1881	CDD:409565
Ig strand F	1889..1896	CDD:409565
Ig strand G	1899..1909	CDD:409565