DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Drak and Speg

DIOPT Version :9

Sequence 1:NP_001162723.1 Gene:Drak / 32097 FlyBaseID:FBgn0052666 Length:674 Species:Drosophila melanogaster
Sequence 2:XP_038939815.1 Gene:Speg / 363256 RGDID:2124 Length:3269 Species:Rattus norvegicus


Alignment Length:952 Identity:188/952 - (19%)
Similarity:324/952 - (34%) Gaps:368/952 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 INEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDN 96
            :::.|::.| ...||.|:.:||.:.:::|..|||||:..:.:.::|.:.....:|.|.    .|.
  Rat  1612 LSDYYDIHQ-EIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQ----HDC 1671

  Fly    97 IVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDL 161
            ::..:...|.|....::.||.| .||...:..:..:.|::.|..||:||:.:.:||...:.|||:
  Rat  1672 VLYFHEAFERRRGLVIVTELCT-EELLERMARKPTVCESETRTYMRQVLEGIGYLHQSHVLHLDV 1735

  Fly   162 KPQNILL-AGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGV 225
            ||:|:|: .|...|:.:::||||.::.:..|.......|||::||||::...|:|.:||||.|||
  Rat  1736 KPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQFGTPEFVAPEIVNQSPVSGVTDIWPVGV 1800

  Fly   226 LTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATG-- 288
            :.::.|:|.|||.|:..:.|.:||....:.|.:..|..:|..|..|:   :::...||:..|.  
  Rat  1801 VAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFL---IKVLVQDRLRPTAEE 1862

  Fly   289 CLDHIWLKDDCS------------LDRQ------------IYLQP-------------------- 309
            .|:|.|.|.:..            |.|:            :.|:|                    
  Rat  1863 TLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVAMPRRQ 1927

  Fly   310 --------QSDAEEEEEEDV-------------------DDDVEDE---------------EEEE 332
                    .||:||||.|::                   |...|||               :|:.
  Rat  1928 PPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPEAGAATPMDWQEQG 1992

  Fly   333 QVEEEEEETQNVE------------------------------------EP--------TTEAPQ 353
            :...:::|..:.|                                    ||        :.|.||
  Rat  1993 RAPSKDQEAPSPEALPSPGQESPDGPSPRRPELRRGSSAESALPRVGSREPGRSLHKAASVELPQ 2057

  Fly   354 ----------------------QQQQPVQQH-----------------------------QLAKS 367
                                  |:.|.::|.                             ::|::
  Rat  2058 RRSPSPGATRLTRGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARA 2122

  Fly   368 GQIHSKPTH----------------------NGHHRANSGGSISKIPIA---TSKLQSTPS---- 403
            ....:.|.|                      .|.||  ..|:..:||:|   ..:||.:||    
  Rat  2123 ASSEAAPHHQPPPESRGLQKSSSFSQGEAEPRGRHR--RAGAPLEIPVARLGARRLQESPSLSAL 2185

  Fly   404 SETTTAIHTLTSNSNGHVHKPTQIVTPTRRAS-------------DSDKENTYTATFVKKPVATI 455
            |||......|.|.....:.|..:....|.|.|             ...|.....|....:|...:
  Rat  2186 SETQPPSPALPSAPKPSITKSPEPSAATSRDSPQPPAPQPVPEKIPEPKPEPVRAAKPAQPPLAL 2250

  Fly   456 QLGSSNGIEDATVVATL-----TLFPDA-PTTPKV-------IRKTPTGESNGSATSVK---ALV 504
            |:.:.:....|.::.:|     ||.|.. |:.||.       :...|.|.|.....|.:   .|.
  Rat  2251 QMPAQSLTPYAQIMQSLQLSSPTLSPQVPPSEPKPHAAVFARVASPPPGASEKRVPSARIPPVLA 2315

  Fly   505 KKFQLEDSSGSAVARRSGGAVTSS----------------------------------------- 528
            :|.::     ..|..|.|.:::.|                                         
  Rat  2316 EKVRV-----PTVPPRPGSSLSGSIENLESEAVFEAKFKRSRESPLSRGLRLLSRSRSEERGPFR 2375

  Fly   529 ----SGLHSPTTTSVRLNSIRR------------ASEP---------LTTVYKK----------- 557
                .|::.|:.....|..:||            |.||         |:...::           
  Rat  2376 GAEDDGIYRPSPAGTPLELVRRPERSRSVQDLRVAGEPGLVRRLSLSLSQKLRRTPPGQRHPAWE 2440

  Fly   558 ------QTSQNGCSSTSNP--------SSS----------PGSSPTTSGST--ATLLIHSQRLGN 596
                  ::|:.|.|:..:|        ||:          .|||..:.|::  :|.|....|...
  Rat  2441 SRSGDGESSEGGSSARGSPVLAVRRRLSSTLERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRAT 2505

  Fly   597 STAPASHCVAVP-------ATATATSSASSSNSSSGKSTSAA 631
            |...:...:.||       ..||..|:.|..:.:||.|.|:|
  Rat  2506 SEGESLRRLGVPHNQLASQTGATTPSAESLGSEASGTSGSSA 2547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DrakNP_001162723.1 STKc_DRAK 28..295 CDD:271008 81/265 (31%)
S_TKc 45..295 CDD:214567 79/252 (31%)
PHA03255 379..>554 CDD:165513 50/276 (18%)
SpegXP_038939815.1 I-set 45..127 CDD:400151
Ig strand A 45..47 CDD:409353
Ig strand A' 49..55 CDD:409353
Ig strand B 62..69 CDD:409353
Ig strand C 75..80 CDD:409353
Ig strand C' 82..85 CDD:409353
Ig strand F 106..114 CDD:409353
Ig strand G 117..127 CDD:409353
PHA03247 <324..681 CDD:223021
Ig strand A 736..739 CDD:409353
I-set 737..826 CDD:400151
Ig strand A' 742..746 CDD:409353
Ig strand B 754..762 CDD:409353
Ig strand C 767..772 CDD:409353
Ig strand C' 775..777 CDD:409353
Ig strand D 783..788 CDD:409353
Ig strand E 791..796 CDD:409353
Ig strand F 805..813 CDD:409353
Ig strand G 816..826 CDD:409353
SPEG_u2 827..883 CDD:293256
IgI_APEG-1_like 884..974 CDD:409567
Ig strand B 901..905 CDD:409567
Ig strand C 914..918 CDD:409567
Ig strand E 940..944 CDD:409567
Ig strand F 954..959 CDD:409567
Ig strand G 967..970 CDD:409567
Ig 988..1073 CDD:416386
Ig strand A' 991..994 CDD:409353
Ig strand B 998..1007 CDD:409353
Ig strand C 1012..1018 CDD:409353
Ig strand C' 1021..1023 CDD:409353
Ig strand D 1030..1035 CDD:409353
Ig strand E 1038..1045 CDD:409353
Ig strand F 1053..1060 CDD:409353
Ig strand G 1063..1073 CDD:409353
Ig 1079..1168 CDD:416386
Ig strand A 1079..1082 CDD:409353
Ig strand A' 1085..1090 CDD:409353
Ig strand B 1095..1102 CDD:409353
Ig strand C 1109..1115 CDD:409353
Ig strand C' 1116..1119 CDD:409353
Ig strand D 1124..1130 CDD:409353
Ig strand E 1133..1143 CDD:409353
Ig strand F 1147..1155 CDD:409353
Ig strand G 1157..1168 CDD:409353
I-set 1203..1292 CDD:400151
Ig strand A 1203..1206 CDD:409353
Ig strand A' 1209..1214 CDD:409353
Ig strand B 1219..1226 CDD:409353
Ig strand C 1233..1239 CDD:409353
Ig strand C' 1240..1243 CDD:409353
Ig strand D 1248..1254 CDD:409353
Ig strand E 1257..1267 CDD:409353
Ig strand F 1271..1279 CDD:409353
Ig strand G 1281..1292 CDD:409353
I-set 1500..1589 CDD:400151
Ig strand A' 1508..1511 CDD:409353
Ig strand B 1515..1524 CDD:409353
Ig strand C 1529..1535 CDD:409353
Ig strand C' 1538..1540 CDD:409353
Ig strand D 1546..1551 CDD:409353
Ig strand E 1554..1561 CDD:409353
Ig strand F 1569..1576 CDD:409353
Ig strand G 1579..1589 CDD:409353
STKc_SPEG_rpt1 1613..1869 CDD:271010 81/264 (31%)
PHA03247 <1951..2352 CDD:223021 60/407 (15%)
I-set 2594..2684 CDD:400151
Ig strand A 2594..2596 CDD:409353
Ig strand A' 2599..2604 CDD:409353
Ig strand B 2611..2619 CDD:409353
Ig strand C 2624..2628 CDD:409353
Ig strand D 2639..2646 CDD:409353
Ig strand E 2649..2654 CDD:409353
Ig strand F 2663..2671 CDD:409353
Ig strand G 2674..2684 CDD:409353
PHA03247 <2785..2910 CDD:223021
PKc_like 2964..3220 CDD:419665
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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