DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drak and ppk16

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_594821.1	Gene:	ppk16 / 2543567	PomBaseID:	SPAC890.03	Length:	672	Species:	Schizosaccharomyces pombe

Alignment Length:	706	Identity:	167/706 - (23%)
Similarity:	256/706 - (36%)	Gaps:	176/706 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PDINEI--YEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCE 92
            |.|:::  |.:|.. ...|.|..|..|.|..|.:....| ...|::|....:||.|...:|
pombe    23 PRISDVGTYRIESV-VGEGSFGKVYLAAHLLTNTKVVLK-SSCRKQAIILAREIHHHRRLL---- 81

  Fly    93 GEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIA 157
             ..||..|..|..|.....|.:|....|||...:..|:.|.|......|.::..|:::||.:...
pombe    82 -HPNITRLYEVVCTEDRIYLAMEYCPNGELYDWVAREKRLDEKTTCRIMWQLCCAIQYLHRQGCV 145

  Fly   158 HLDLKPQNILLAGERIED---GLKLCDFGISR-VVCEG---INVREMAGTPDYVAPEVLQ-YEPL 214
            |.|||.:||.|      |   .:||.|||.|| ..|..   :|.|  .||..|.|||::| ::.:
pombe   146 HRDLKLENIFL------DKAYNVKLGDFGFSRDSDCSRRTFMNTR--CGTVAYCAPELVQGHKYI 202

  Fly   215 SLLTDIWSVGVLTYVLLSGFSPFGGD----TKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRA 275
            ....||||:|::.|.||.|..||..|    |:|:.   |::|. .:|:.|....|.:....:.:.
pombe   203 GECVDIWSLGIIMYALLIGRLPFDEDDVSLTEQKI---INECP-QYPETLSKNSSSLLKSLLCKD 263

  Fly   276 LRIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQVEEEEEE 340
            .|::|                   |:| ||...|...........:.|.....:.||:|.:..|.
pombe   264 YRLRP-------------------SID-QIISHPYFKENGYHSSSIRDPRPSSKAEEKVRKRLEF 308

  Fly   341 T-QNVEEPTTEAPQQQ------------QQPVQQHQLAKSGQIHSKPTHNGHHRANSGGSISKIP 392
            . .::::......||:            ::.:::....|.|..|.       |:    ||.|.:.
pombe   309 VGVDMDQLNASISQQRCDMFYGWWLLLLEKEMRKENKKKKGLFHL-------HK----GSSSAVH 362

  Fly   393 IATSKLQSTPSSETTTAIHTLTSNSNGHVHKPTQIVTPTRRASDSDKENTYTATFVK-----KPV 452
            ||    .:|||.:|...  ::.||:...:..         |.:.||..|:..:||..     |..
pombe   363 IA----PATPSLKTAQV--SVMSNNQDSLKS---------RHTSSDSSNSLLSTFRSWLFDPKQK 412

  Fly   453 ATIQLGSSNGIEDAT-------------------------VVATLTLFP----------DAPTTP 482
            .|....||:.|...|                         .|..||:||          :.|.|.
pombe   413 HTADTLSSSAIRPRTPSPSAENYLTQENFDSDNLSESLDNSVENLTVFPSINSFGRRHSNLPQTT 477

  Fly   483 KVIRKTPTGESNGSATSVKALVKKFQLEDSSGSAVARRSGGAVTSSSGLH-------SP-TTTSV 539
            .|    .|||.|...|  ..|:|...|:.:........|..:.:.||.|.       || ..|.:
pombe   478 HV----DTGEQNTPFT--PPLLKTVNLDGNKDFTFPSNSQNSPSKSSNLSINIDIPPSPLQNTVI 536

  Fly   540 RLNSIRRASEPLTTVYKKQTSQNGCSSTSNPSSSPGSSPTTSGSTATLLIHSQRLGNSTAPASHC 604
            .....||:..|:.::          |..|:.:||..||.|.|.|..           |:|.::..
pombe   537 SPQPTRRSRTPIRSL----------SGRSSVASSRNSSRTRSYSNV-----------SSASSNSL 580

  Fly   605 VAVPATATATSSASSSNSSSGKSTSAAHHLHHHHMHHHHHHHHHHVVIAAKNAAAV 660
            :::         .||..|||........|.....:|...|...........||.|:
pombe   581 ISI---------ISSKPSSSTVQRQTPFHSPFERLHKSFHFPSGEPFNTRINATAI 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	80/278 (29%)
		S_TKc	45..295	CDD:214567	76/261 (29%)
		PHA03255	379..>554	CDD:165513	50/222 (23%)
ppk16	NP_594821.1	S_TKc	31..279	CDD:214567	83/286 (29%)
ppk16	NP_594821.1	STKc_AMPK-like	31..278	CDD:270905	82/285 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000