DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drak and Camk1g

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_011237234.1	Gene:	Camk1g / 215303	MGIID:	2388073	Length:	491	Species:	Mus musculus

Alignment Length:	479	Identity:	124/479 - (25%)
Similarity:	200/479 - (41%)	Gaps:	84/479 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDT 110
            |.|:.|.....:.||..||.|.:|:....:  |..:::|||||...:.| |||.|..::|:.:..
Mouse    32 GAFSEVFLVKQRVTGKLFALKCIKKSPAFR--DSSLENEIAVLKRIKHE-NIVTLEDIYESTTHY 93

  Fly   111 ALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIED 175
            .|:::|.:||||...:......||..|...:::||.|:|:||:..|.|.||||:|:|........
Mouse    94 YLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENS 158

  Fly   176 GLKLCDFGISRVVCEGINVREMAGTPDYV--------------APEVLQYEPLSLLTDIWSVGVL 226
            .:.:.|||:|::...|: :....|||.||              |||||..:|.|...|.||:||:
Mouse   159 KIMITDFGLSKMEQNGV-MSTACGTPGYVAHREGKSRKDLKKEAPEVLAQKPYSKAVDCWSIGVI 222

  Fly   227 TYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLD 291
            ||:||.|:.||..:|:.:.|..|.:....|....:..:|..|.|||...|...||:|......|.
Mouse   223 TYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALR 287

  Fly   292 HIWLKDDCSLDRQIY----LQPQSDAEEEE----------------------EEDVDDDVEDE-- 328
            |.|:..:.:|.|.||    ||.|.:..:.:                      ...|..:||:.
Mouse   288 HPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNLHSPSVRQEVENRPP 352

  Fly   329 -EEEEQVEEEEEETQNVEE-----PTTEAPQQQQQPVQQHQLAKSGQIHSKPTHNGHHRANSGG- 386
             ....:|...:....::.|     |:|..|...:.|.               :|:....|.|||
Mouse   353 VSPAPEVSRPDSHDSSITEAPILDPSTPLPALTRLPC---------------SHSSRPSAPSGGR 402

  Fly   387 ------------SISKIPIATSKLQSTPSSETTTAIHTLTSNSNGHVHKPTQIVTPTRRASDSDK 439
                        |.|.:|:....|.:.|....::.::......:.:..:||..    |:|:....
Mouse   403 SLNCLVNGSLRISSSLVPMQQGPLATGPCGCCSSCLNIGNKGKSSYCSEPTLF----RKANKKQN 463

  Fly   440 ENTYTATFVKKPVATIQLGSSNGI 463
            ..:.....||...:|...|...|:
Mouse   464 FKSEVMVPVKAGGSTHCRGGQTGV 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	88/262 (34%)
		S_TKc	45..295	CDD:214567	88/262 (34%)
		PHA03255	379..>554	CDD:165513	18/98 (18%)
Camk1g	XP_011237234.1	STKc_CaMKI_gamma	19..317	CDD:271068	96/288 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910