Protein Alignment Drak and mlck-1

DIOPT Version :10

• Sequence 1: NP_996411.2
• Gene: Drak / 32097
• FlyBaseID: FBgn0052666
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_509689.1
• Gene: mlck-1 / 181217
• WormBaseID: WBGene00013869
• Length: 1211
• Species: Caenorhabditis elegans
• Alignment Length: 678
• Identity: 167/678 - (24%)
• Similarity: 281/678 - (41%)
• Gaps: 169/678 - (24%)

  Fly     6 GIFPIGDGLLDVDADRLKGLLVSCP--DINEI------------YEVEQTPFARGKFAAVRRAIH 56
            |..|.|.|.:.|| :.....|...|  |:.:|            |:|.:. ...|||..|...|.
 Worm     2 GTEPSGSGKIKVD-EHYPSELDEPPVFDVKKIENIRANVKFDTLYQVTKL-LGDGKFGKVYCVIE 64

  Fly    57 KNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGE 121
            |.||..|||||:|.|:.|..:  |::.|:::|............:|.:.|.:|..|::|:..|||
 Worm    65 KETGKEFAAKFIKIRKEADRA--EVEREVSILTQLRHPRIAQIYDAFYTTTNDVVLIMEIVRGGE 127

  Fly   122 L-QTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNIL---LAGERIEDGLKLCDF 182
            | ..:.:....|:|......:.::.:|:.::|.::|.|||:||:||:   |.|.||    ||.||
 Worm   128 LFDRVAEESYVLSELAVVMIICQLCEAIDYIHKQNILHLDVKPENIMCVSLTGNRI----KLIDF 188

  Fly   183 GISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFL 247
            |::|.......::.|||||::.||||:::|.|...||:||:||:||:||||:|||.||...||:.
 Worm   189 GLARHYDGTQELKYMAGTPEFAAPEVIKFEKLDYHTDMWSIGVITYILLSGYSPFLGDNLGETYC 253

  Fly   248 NISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL-----KDDC-------- 299
            |:.:....|.:. |..|:..|.||:.:.|....:.||....||.|.|:     |..|
 Worm   254 NVEKGVWEFTEE-FDTVTEEAKDFVTKLLVYDQSKRMLPHECLQHPWIAKHRQKAACNTILEKPL 317

  Fly   300 ---SLD-RQI---------------------------------------YLQPQSDAEEEEEEDV 321
               :|| :||                                       :..|.....|::|:.:
 Worm   318 NAPTLDNKQIMRYNARRKFRRMIIYVKFLIEMNRLRNSLKTRMSANGHKFFDPLLKMAEKKEQKI 382

  Fly   322 DDDVE---------DEEEEEQVEEEEEETQNVEEPTTEAPQQQQQPVQQHQLAKSGQIHSKPTHN 377
            .:.:.         ....:..|:.::   :|.:.|.|:......:| ::.:..|..:|
 Worm   383 SNAIGTAGCPASGLGSLVKMAVDSQK---KNGDVPVTQDANMSTEP-EKEEKKKKKKI------- 436

  Fly   378 GHHRANSGGSISKIPIATSKLQSTPSSETTTAIHTLTSNSNGHVHKPTQIVTPTRRASDSDKENT 442
                ||:.||        :|.:.|.|.:....:.|   :.:..:..|.:::  |:||| :..|:.
 Worm   437 ----ANADGS--------TKTEKTSSVKKKKLVET---DGDAGLRPPPELM--TKRAS-TGGESL 483

  Fly   443 YTATFVKKPVATIQLGSS-------NGIEDATVVA----------------------------TL 472
            ..|..|.|.:..::.|:|       :..|:..:.|                            ||
 Worm   484 LAAVKVLKNLEVVENGNSPKRKSLCSVKEEKEIPAKKQTEGYKTLETTENGDIRRKSAPVKQDTL 548

  Fly   473 TLFPDAPTTPKVIRKTPTGESNGSATSVKALVKKFQLEDSS---GSAVARRSGGAV--TSSSGLH 532
            |...::..||:::...|.||....:.|.|        |:.|   ...:.::|..:|  |.:..|.
 Worm   549 TCQDNSKVTPQLLETAPNGEIRRKSASAK--------EEKSVKPEEVIRKKSSASVKETKTVELS 605

  Fly   533 SPTTTSVRLNSIRRASEPLTTVYKKQTS 560
            .......:|.||....|.|....||.|:
 Worm   606 VVPVKLEKLASIDEKGEKLVKKKKKTTT 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_996411.2	STKc_DRAK	28..295	CDD:271008	98/284 (35%)
		PHA03255	379..>554	CDD:165513	42/214 (20%)
mlck-1	NP_509689.1	Protein Kinases, catalytic domain	51..300	CDD:473864	93/255 (36%)