DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and Stk17b

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_596883.1	Gene:	Stk17b / 170904	RGDID:	620457	Length:	371	Species:	Rattus norvegicus

Alignment Length:	345	Identity:	130/345 - (37%)
Similarity:	198/345 - (57%)	Gaps:	29/345 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DADRLKGLLVSCP-------DINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQ 75
            |...:.|||.:.|       :.|..|.:......|||||.||:.|.|:||..:||||||:|||.|
  Rat     7 DCRSISGLLTTTPQTPMKTENFNNFYTLTPKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQ 71

  Fly    76 SSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNE--ECLTEAQAR 138
            ....||.||||||.|.....:::||:.|:||.::..|:||.|.|||:..:...|  |.::|....
  Rat    72 DCRAEILHEIAVLELARSCPHVINLHEVYETATEIILVLEYAAGGEIFNLCLPELAEMVSENDVI 136

  Fly   139 HCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDY 203
            ..::::|:.:.:||..:|.|||||||||||:.......:|:.|||:||.:.....:||:.|||:|
  Rat   137 RLIKQILEGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEY 201

  Fly   204 VAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVA 268
            :|||:|.|:|::..||:|::|::.|:||:..|||.|:..|||:|||||..:.:.:.:|..||.:|
  Rat   202 LAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLA 266

  Fly   269 IDFIRRALRIKPNDRMNATGCLDHIWLK--DDCSLDRQIYLQPQSDAEEEEEEDV---------- 321
            .|||:..|...|..|..|..||.|.||:  |..||     ..|:..:|..:.:|:
  Rat   267 TDFIQSLLVKNPEKRPTAESCLSHSWLQQWDFGSL-----FHPEETSESSQTQDLSLRSSEDKTP 326

  Fly   322 ---DDDVEDEEEEEQVEEEE 338
               :....|.|::|.:.|::
  Rat   327 KSCNGSCGDREDKENIPEDD 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	114/275 (41%)
		S_TKc	45..295	CDD:214567	111/251 (44%)
		PHA03255	379..>554	CDD:165513
Stk17b	NP_596883.1	STKc_DRAK2	24..293	CDD:271100	113/268 (42%)
Stk17b	NP_596883.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..345		5/36 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31231
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004726
OrthoInspector	1	1.000	-	-		otm44921
orthoMCL	1	0.900	-	-		OOG6_106249
Panther	1	1.100	-	-	O	PTHR24342
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3322
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.910