DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and DAPK3

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001339.1	Gene:	DAPK3 / 1613	HGNCID:	2676	Length:	454	Species:	Homo sapiens

Alignment Length:	326	Identity:	122/326 - (37%)
Similarity:	186/326 - (57%)	Gaps:	29/326 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQS----SDKEIKHEIAVLMLC 91
            |:.:.||:.: ....|:||.||:...|.||..:||||:|:||.:.|    |.:||:.|:.:|...
Human     8 DVEDHYEMGE-ELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREI 71

  Fly    92 EGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSI 156
            . ..||:.|:.:.|.::|..|:|||.:||||...|..:|.|||.:|...::::|..:.:||.:.|
Human    72 R-HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRI 135

  Fly   157 AHLDLKPQNILLAGERIED-GLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDI 220
            ||.||||:||:|..:.:.: .:||.||||:..:..|...:.:.|||::||||::.||||.|..|:
Human   136 AHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADM 200

  Fly   221 WSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMN 285
            ||:||:||:||||.|||.|:|||||..|||.....|.:..|...|.:|.|||||.|...|..||.
Human   201 WSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMT 265

  Fly   286 ATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQVEEEEEETQNVEEPTTE 350
            ....|:|.|:|   ::.|:                   :|..|:...:.|....:|..::|.|.:
Human   266 IAQSLEHSWIK---AIRRR-------------------NVRGEDSGRKPERRRLKTTRLKEYTIK 308

  Fly   351 A 351
            :
Human   309 S 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	113/268 (42%)
		S_TKc	45..295	CDD:214567	110/254 (43%)
		PHA03255	379..>554	CDD:165513
DAPK3	NP_001339.1	STKc_DAPK	7..275	CDD:271007	113/268 (42%)
		Activation segment. /evidence=ECO:0000250\|UniProtKB:O96017	161..204		20/42 (48%)
		Leucine-zipper. /evidence=ECO:0000303\|PubMed:9488481	427..441
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910