DRSC/TRiP Functional Genomics Resources

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Protein Alignment Drak and DAPK1

DIOPT Version :9

Sequence 1:NP_001162723.1 Gene:Drak / 32097 FlyBaseID:FBgn0052666 Length:674 Species:Drosophila melanogaster
Sequence 2:NP_001275658.1 Gene:DAPK1 / 1612 HGNCID:2674 Length:1430 Species:Homo sapiens


Alignment Length:293 Identity:115/293 - (39%)
Similarity:175/293 - (59%) Gaps:10/293 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 DINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQS----SDKEIKHEIAVLMLC 91
            ::::.|:..: ....|:||.|::...|:||..:||||:|:||...|    |.::|:.|:::|...
Human     8 NVDDYYDTGE-ELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI 71

  Fly    92 EGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSI 156
            : ..|::.|:.|:|.::|..|:|||..||||...|..:|.|||.:|...::::|..:.:||...|
Human    72 Q-HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQI 135

  Fly   157 AHLDLKPQNILLAGERI-EDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDI 220
            ||.||||:||:|....: :..:|:.|||::..:..|...:.:.|||::||||::.||||.|..|:
Human   136 AHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADM 200

  Fly   221 WSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMN 285
            ||:||:||:||||.|||.|||||||..|:|.....|.|..|...|.:|.|||||.|...|..||.
Human   201 WSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMT 265

  Fly   286 ATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEE 318
            ....|.|.|:|..   |.|..|..::.|...|:
Human   266 IQDSLQHPWIKPK---DTQQALSRKASAVNMEK 295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DrakNP_001162723.1 STKc_DRAK 28..295 CDD:271008 108/268 (40%)
S_TKc 45..295 CDD:214567 107/254 (42%)
PHA03255 379..>554 CDD:165513
DAPK1NP_001275658.1 STKc_DAPK1 7..275 CDD:271096 108/268 (40%)
Calmodulin-binding 267..334 9/32 (28%)
Autoinhibitory domain. /evidence=ECO:0000250 292..301 1/4 (25%)
ANK 373..497 CDD:238125
ANK repeat 378..409 CDD:293786
ANK 1 378..407
ANK 2 411..440
ANK repeat 412..442 CDD:293786
ANK 439..564 CDD:238125
ANK repeat 444..475 CDD:293786
ANK 3 444..473
ANK repeat 477..508 CDD:293786
ANK 4 477..506
ANK 505..629 CDD:238125
ANK repeat 510..541 CDD:293786
ANK 5 510..539
Ank_2 <515..768 CDD:330894
ANK repeat 543..574 CDD:293786
ANK 6 543..572
ANK repeat 576..607 CDD:293786
ANK 7 576..605
ANK repeat 609..638 CDD:293786
ANK 8 609..638
ANK 9 875..904
ANK 10 1162..1196
Death_DAPK1 1308..1393 CDD:260052
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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