DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drak and trio

DIOPT Version :9

Sequence 1:	NP_001162723.1	Gene:	Drak / 32097	FlyBaseID:	FBgn0052666	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_012819807.1	Gene:	trio / 100170157	XenbaseID:	XB-GENE-922516	Length:	3085	Species:	Xenopus tropicalis

Alignment Length:	273	Identity:	98/273 - (35%)
Similarity:	154/273 - (56%)	Gaps:	4/273 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GLLVSCPDINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVL 88
            ||.|...:..:|...|.....||:|:.|::...:.|....|.||:.::...:.   ::.||:.:|
Frog  2771 GLRVIWKENFDIAYSEVAELGRGRFSVVKKCEQRVTRRIVATKFVNKKLMKRD---QVTHELGIL 2832

  Fly    89 MLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHD 153
            ...: ...:::|....||.:...|:||:|..|.|...:.....|||.:....|||||:||::||:
Frog  2833 QSLQ-HPQLISLLDTFETPASYVLVLEIADQGCLLEYVVQWGNLTEEKITSYMREVLEALQYLHN 2896

  Fly   154 RSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLT 218
            ..||||||||:|||:.....:..:||.|||.:..:.....:.::.|:.::.|||::...|:||.:
Frog  2897 CRIAHLDLKPENILVDQSLTKPTIKLSDFGDAVQLNTTYYIHQLLGSAEFAAPEIILGNPVSLTS 2961

  Fly   219 DIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDR 283
            ||||:||||||||||.|||..::.:||.|||.:...:|||:.|.|||..|.:|:...|:.....|
Frog  2962 DIWSIGVLTYVLLSGVSPFLDESVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQGDQTKR 3026

  Fly   284 MNATGCLDHIWLK 296
            .:|..||...||:
Frog  3027 PSAAVCLKEQWLQ 3039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drak	NP_001162723.1	STKc_DRAK	28..295	CDD:271008	93/266 (35%)
		S_TKc	45..295	CDD:214567	91/249 (37%)
		PHA03255	379..>554	CDD:165513
trio	XP_012819807.1	SEC14	64..199	CDD:214706
		SPEC	215..440	CDD:238103
		SPEC	336..561	CDD:238103
		SPEC	562..778	CDD:238103
		SPEC	782..1009	CDD:238103
		SPEC	903..1132	CDD:238103
		SPEC	1138..1238	CDD:197544
		RhoGEF	1289..1459	CDD:238091
		PH1_Kalirin_Trio_like	1466..1588	CDD:270060
		SH3_Kalirin_1	1654..1713	CDD:212786
		SH3-RhoG_link	1710..1967	CDD:293215
		RhoGEF	1965..2138	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2143..2281	CDD:270061
		SH3_Kalirin_2	2543..2601	CDD:212787
		I-set	2673..2764	CDD:254352
		Ig	2687..2764	CDD:299845
		STKc_Trio_C	2776..3038	CDD:271015	93/265 (35%)
		S_TKc	2784..3038	CDD:214567	92/257 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910