Protein Alignment Atp11c and CG33298

DIOPT Version :10

• Sequence 1: NP_001032952.1
• Gene: Atp11c / 320940
• MGIID: 1859661
• Length: 1129
• Species: Mus musculus
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1302
• Identity: 402/1302 - (30%)
• Similarity: 596/1302 - (45%)
• Gaps: 265/1302 - (20%)

Mouse     3 RRTLNRLCAGE--EKRVGTRTVFVGNHPISGTEP---YIAQRFCDNRIVSSKYTLWNFLPKNLFE 62
            |.||.....|:  |:| ..||| |.||.:....|   :...:|..|:|.::||||.:|:||||.|
  Fly   210 RLTLCNYNTGDKFEER-SYRTV-VPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLE 272

Mouse    63 QFRRIANFYFLIIFLVQ-VTVDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSA-- 124
            ||.|:||.||:.|.|:. |...:......:.:|:.||:.|||:|..:||..|..:|..:|.:.
  Fly   273 QFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCR 337

Mouse   125 VYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYA 189
            ||..|..:..:.:.::::|||:|.:..|||.|.|::||.:....|.||:.|..||||:|.|....
  Fly   338 VYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREV 402

Mouse   190 VRDTIALCTAESIDNLRATIECEQPQPDLYRFVGRISIYSNSIEAVARSLGPENLLLKGATLKNT 254
            ||....:.:........:.:|.:.|...||||.|.: |:... |.|  .:..|.|||:.:.||||
  Fly   403 VRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGAL-IHPTG-ERV--PISTECLLLRESRLKNT 463

Mouse   255 KKIYGVAVYTGMETKMALNYQGKSQKCSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSS--- 316
            ..|.|:.||.|.|||..||..|...|.|.||:.:|..:|..:.|||....|......:|.||
  Fly   464 DYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTH 528

Mouse   317 ---PYNDEPWYNQKTQKERETFQVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDK 378
               ||...    .|.....|:..:      |.:::|:...:||:|:|||:|:.|.|..|.|..:.
  Fly   529 FPVPYLPP----NKLTANMESMWI------FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNV 583

Mouse   379 DFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEVDGLSQ 443
            |.||.|.|:.......::.|||||:.::|||||||||||.|.|..|.::|..|.....|::.:..
  Fly   584 DLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYS 648

Mouse   444 TDG----PLAYFDKADKNREAL---------------FLRALCLCHTV----------------- 472
            ..|    ||...|..:.:...|               ||..|.:|:||
  Fly   649 KPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGII 713

Mouse   473 ----------EMK-----------------TNDDVDGP-----------------VEGAGFT--- 490
                      .:|                 |...::||                 .|....|
  Fly   714 EVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSP 778

Mouse   491 ----------------------------------------------------------------- 490
                                                                             
  Fly   779 PPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSI 843

Mouse   491 --------------------------------YISSSPDEIALVKGAKRFGFTFLGNQNGYIRVE 523
                                            |.:.||||:|||..|..:....|......|.|.
  Fly   844 ATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVS 908

Mouse   524 -NQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKG--DILLFCKGADSSIFPRV--HSHQI----- 578
             .......|||:|..|.|||.|:.||::|| |.|  :|:|:.|||||||.|.:  .||..
  Fly   909 MPMAGATREYEILKVLPFDSSRKCMSIVVR-QIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGIL 972

Mouse   579 -ELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNL 642
             |.|:..::|.|.:|.|.|.:|.:.:...|:....|:..|.:|:|::||.:|...|.::|:|:.|
  Fly   973 REQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTL 1037

Mouse   643 IGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEE 707
            :|||.:||:|||...|||.:|.:||:.||||||||.|||.:..|:.:||....||:.||.
  Fly  1038 LGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTA----- 1097

Mouse   708 SERKEDRLHELLIEYRKKLLHEFPKST----RSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSS 768
              |..|.....:..|...:.::...||    :||:|     ::..|::||.||:.||:...
  Fly  1098 --RSRDAAETAINFYLTDMENDKTTSTLGYGQSLRK-----KQRALVVDGKTLTFILDPKS---- 1151

Mouse   769 NNYKSI--FLQICMKCTAVLCCRMAPLQKAQIVRMVK---NLKGSPITLSIGDGANDVSMILESH 828
               |.|  ||::..:|.:|||||..|||||.:|::||   ||:    ||:|||||||||||..:.
  Fly  1152 ---KLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLR----TLAIGDGANDVSMIQMAD 1209

Mouse   829 VGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQF 893
            ||:||.|:||.||...:|:::|:|::|::|||.||:..|.|::.::.||||||..|:...|.||.
  Fly  1210 VGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQL 1274

Mouse   894 FCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLH 958
            :||||.|.:.|..||.:||:.|||||.||..:.::.:..|.|..:|.||.  .|...:...|...
  Fly  1275 YCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK--NGRLGVAYRPHDF 1337

Mouse   959 WTFL--AAFEGTVFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWI 1021
            |..|  |.::..|.||.....:..|.:       |.|.|||.:....:|...:..|::.|.||.:
  Fly  1338 WLILLDALYQSLVIFFVALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVL 1395

Mouse  1022 NHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIV 1086
            :...|..||..:..|:..:..:.......:..|:|......|...||.|:|...:::.|.:||..
  Fly  1396 HVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTT 1460

Mouse  1087 VK 1088
            |:
  Fly  1461 VR 1462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atp11c	NP_001032952.1	P-type_ATPase_APLT_Dnf-like	42..974	CDD:319770	362/1142 (32%)
		Di-leucine motif. /evidence=ECO:0000250|UniProtKB:Q8NB49	1113..1118
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	362/1142 (32%)