DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp11c and CG33298

DIOPT Version :9

Sequence 1:	NP_001032952.1	Gene:	Atp11c / 320940	MGIID:	1859661	Length:	1129	Species:	Mus musculus
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1302	Identity:	402/1302 - (30%)
Similarity:	596/1302 - (45%)	Gaps:	265/1302 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 RRTLNRLCAGE--EKRVGTRTVFVGNHPISGTEP---YIAQRFCDNRIVSSKYTLWNFLPKNLFE 62
            |.||.....|:  |:| ..||| |.||.:....|   :...:|..|:|.::||||.:|:||||.|
  Fly   210 RLTLCNYNTGDKFEER-SYRTV-VPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLE 272

Mouse    63 QFRRIANFYFLIIFLVQ-VTVDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSA-- 124
            ||.|:||.||:.|.|:. |...:......:.:|:.||:.|||:|..:||..|..:|..:|.:.
  Fly   273 QFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCR 337

Mouse   125 VYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYA 189
            ||..|..:..:.:.::::|||:|.:..|||.|.|::||.:....|.||:.|..||||:|.|....
  Fly   338 VYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREV 402

Mouse   190 VRDTIALCTAESIDNLRATIECEQPQPDLYRFVGRISIYSNSIEAVARSLGPENLLLKGATLKNT 254
            ||....:.:........:.:|.:.|...||||.|.: |:... |.|  .:..|.|||:.:.||||
  Fly   403 VRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGAL-IHPTG-ERV--PISTECLLLRESRLKNT 463

Mouse   255 KKIYGVAVYTGMETKMALNYQGKSQKCSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSS--- 316
            ..|.|:.||.|.|||..||..|...|.|.||:.:|..:|..:.|||....|......:|.||
  Fly   464 DYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTH 528

Mouse   317 ---PYNDEPWYNQKTQKERETFQVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDK 378
               ||...    .|.....|:..:      |.:::|:...:||:|:|||:|:.|.|..|.|..:.
  Fly   529 FPVPYLPP----NKLTANMESMWI------FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNV 583

Mouse   379 DFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEVDGLSQ 443
            |.||.|.|:.......::.|||||:.::|||||||||||.|.|..|.::|..|.....|::.:..
  Fly   584 DLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYS 648

Mouse   444 TDG----PLAYFDKADKNREAL---------------FLRALCLCHTV----------------- 472
            ..|    ||...|..:.:...|               ||..|.:|:||
  Fly   649 KPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGII 713

Mouse   473 ----------EMK-----------------TNDDVDGP-----------------VEGAGFT--- 490
                      .:|                 |...::||                 .|....|
  Fly   714 EVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSP 778

Mouse   491 ----------------------------------------------------------------- 490

  Fly   779 PPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSI 843

Mouse   491 --------------------------------YISSSPDEIALVKGAKRFGFTFLGNQNGYIRVE 523
                                            |.:.||||:|||..|..:....|......|.|.
  Fly   844 ATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVS 908

Mouse   524 -NQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKG--DILLFCKGADSSIFPRV--HSHQI----- 578
             .......|||:|..|.|||.|:.||::|| |.|  :|:|:.|||||||.|.:  .||..
  Fly   909 MPMAGATREYEILKVLPFDSSRKCMSIVVR-QIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGIL 972

Mouse   579 -ELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNL 642
             |.|:..::|.|.:|.|.|.:|.:.:...|:....|:..|.:|:|::||.:|...|.::|:|:.|
  Fly   973 REQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTL 1037

Mouse   643 IGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEE 707
            :|||.:||:|||...|||.:|.:||:.||||||||.|||.:..|:.:||....||:.||.
  Fly  1038 LGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTA----- 1097

Mouse   708 SERKEDRLHELLIEYRKKLLHEFPKST----RSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSS 768
              |..|.....:..|...:.::...||    :||:|     ::..|::||.||:.||:...
  Fly  1098 --RSRDAAETAINFYLTDMENDKTTSTLGYGQSLRK-----KQRALVVDGKTLTFILDPKS---- 1151

Mouse   769 NNYKSI--FLQICMKCTAVLCCRMAPLQKAQIVRMVK---NLKGSPITLSIGDGANDVSMILESH 828
               |.|  ||::..:|.:|||||..|||||.:|::||   ||:    ||:|||||||||||..:.
  Fly  1152 ---KLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLR----TLAIGDGANDVSMIQMAD 1209

Mouse   829 VGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQF 893
            ||:||.|:||.||...:|:::|:|::|::|||.||:..|.|::.::.||||||..|:...|.||.
  Fly  1210 VGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQL 1274

Mouse   894 FCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLH 958
            :||||.|.:.|..||.:||:.|||||.||..:.::.:..|.|..:|.||.  .|...:...|...
  Fly  1275 YCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK--NGRLGVAYRPHDF 1337

Mouse   959 WTFL--AAFEGTVFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWI 1021
            |..|  |.::..|.||.....:..|.:       |.|.|||.:....:|...:..|::.|.||.:
  Fly  1338 WLILLDALYQSLVIFFVALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVL 1395

Mouse  1022 NHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIV 1086
            :...|..||..:..|:..:..:.......:..|:|......|...||.|:|...:::.|.:||..
  Fly  1396 HVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTT 1460

Mouse  1087 VK 1088
            |:
  Fly  1461 VR 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp11c	NP_001032952.1	P-type_ATPase_APLT_Dnf-like	42..974	CDD:319770	362/1142 (32%)
		Cyt_bd_oxida_II	<993..1083	CDD:376764	21/89 (24%)
		Di-leucine motif. /evidence=ECO:0000250\|UniProtKB:Q8NB49	1113..1118
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	23/49 (47%)
		ATPase-Plipid	250..1473	CDD:273734	389/1260 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	32/91 (35%)
		Cation_ATPase	<880..965	CDD:289987	36/85 (42%)
		HAD_like	<1177..1240	CDD:304363	33/66 (50%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	77/249 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820