Protein Alignment Uba5 and NAE1

DIOPT Version :10

• Sequence 1: NP_572722.2
• Gene: Uba5 / 32094
• FlyBaseID: FBgn0030305
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001273429.1
• Gene: NAE1 / 8883
• HGNCID: 621
• Length: 537
• Species: Homo sapiens
• Alignment Length: 223
• Identity: 43/223 - (19%)
• Similarity: 74/223 - (33%)
• Gaps: 64/223 - (28%)

  Fly     6 DELQAIIADLKTELETE--PKSSGGVASNSR-------------LARDRIDRMSAE--------- 46
            :..:..|.::.|.|.|.  |.|...:.::.|             |||...:.::.|
Human   266 ENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRG 330

  Fly    47 -----VVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYD 106
                 :.||..|.:|..:.|....||             ...||:..|.:|...|.....:.: .
Human   331 TIPDMIADSGKYIKLQNVYREKAKKD-------------AAAVGNHVAKLLQSIGQAPESISE-K 381

  Fly   107 KVELANMNRLFF-------TPDQAGLSKVAAAAATLSFINPDVEIETHNYNITTVENFDRFLDTI 164
            :::|...|..|.       ..::.||..:.......|..|||.||..: ..:..|:.|.:
Human   382 ELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLY-LMLRAVDRFHK----- 440

  Fly   165 SQGGRIAG-------QPVDLVLSCVDNF 185
             |.||..|       :.:..:.||:..|
Human   441 -QQGRYPGVSNYQVEEDIGKLKSCLTGF 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	30/148 (20%)
NAE1	NP_001273429.1	APPBP1_RUB	11..535	CDD:238770	43/223 (19%)
		Interaction with UBA3	334..347		4/12 (33%)