DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba5 and Uba5

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_079968.2	Gene:	Uba5 / 66663	MGIID:	1913913	Length:	403	Species:	Mus musculus

Alignment Length:	410	Identity:	258/410 - (62%)
Similarity:	308/410 - (75%)	Gaps:	13/410 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHAIDELQAIIADLKTELETE-PKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNI 64
            |:.:::.|:..:.:|:.||..| .:.|||   :....|.||..||.||:|||||||||||:||.|
Mouse     1 MADSVERLRQRVEELEQELARERTRRSGG---DGHCGRTRIQEMSDEVLDSNPYSRLMALKRMGI 62

  Fly    65 VKDYERIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFTPDQAGLSKVA 129
            |.||::||..|||||||||||||||:||||||||||:|||||||||||||||||.|.|||||||.
Mouse    63 VSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGLSKVH 127

  Fly   130 AAAATLSFINPDVEIETHNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAA 194
            ||..||..|||||..|.|||||||||:|:.|::.||.||...|||||||||||||||||||||.|
Mouse   128 AAEHTLRNINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTA 192

  Fly   195 CNERNLNWFESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDEKTLKREGVCAASLPTTMG 259
            |||....|.||||||||||||||.:.||::||||||||||||.||||||||||||||||||||||
Mouse   193 CNELGQTWMESGVSENAVSGHIQLMIPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMG 257

  Fly   260 ITAGFLVQNALKYLLNFGEVSDYLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQARPKPVLI 324
            :.||.||||.||:||.||.||.||||||:.||||.|.:||||||||:||..:|:|::.|...:..
Mouse   258 VVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAAALPT 322

  Fly   325 EEKAVSEEP--LHATNEWGIELVAEDAPES-NTTPAETPVMGEGLRLAYEAPEKSSETSEETVSA 386
            :|....||.  :|..||||||||:|.:.|. ..:....|.:.||:.:||..|:|    :|::.|.
Mouse   323 QEAEPQEEAEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKK----TEDSASE 383

  Fly   387 ATADET--SLEDLMAQMKSM 404
            .|.:::  |||||||:||:|
Mouse   384 VTVEDSGESLEDLMARMKNM 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	192/244 (79%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	201/256 (79%)
Uba5	NP_079968.2	ThiF_MoeB_HesA_family	50..293	CDD:238386	191/242 (79%)
		ThiF	51..307	CDD:279270	201/255 (79%)
		UFM1-interacting sequence (UIS). /evidence=ECO:0000250\|UniProtKB:Q9GZZ9	333..345		7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850226
Domainoid	1	1.000	406	1.000	Domainoid score	I712
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11738
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1400
Isobase	1	0.950	-	0	Normalized mean entropy	S1760
OMA	1	1.010	-	-		QHG54107
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006244
OrthoInspector	1	1.000	-	-		oto93208
orthoMCL	1	0.900	-	-		OOG6_104369
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4526
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.710