DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Uba5 and UBA6

DIOPT Version :10

Sequence 1:NP_572722.2 Gene:Uba5 / 32094 FlyBaseID:FBgn0030305 Length:404 Species:Drosophila melanogaster
Sequence 2:NP_060697.4 Gene:UBA6 / 55236 HGNCID:25581 Length:1052 Species:Homo sapiens


Alignment Length:481 Identity:107/481 - (22%)
Similarity:158/481 - (32%) Gaps:160/481 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 DRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGGVGSVTADMLTRCGI----- 97
            ||.|.:.|.:.|    :....||.:||.            :||.|.:|..........|:     
Human   441 DRYDALRACIGD----TLCQKLQNLNIF------------LVGCGAIGCEMLKNFALLGVGTSKE 489

  Fly    98 -GKLILFDYDKVELANMNRLF-FTPDQAGLSK-VAAAAATLSFINPDVEIETH-NYNITTVENF- 157
             |.:.:.|.|.:|.:|:||.| |.|......| ..||.|||. ||..::|:.| |....|.|.. 
Human   490 KGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLK-INSQIKIDAHLNKVCPTTETIY 553

  Fly   158 -DRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAAC--NERNLNWFESGVSENAVSGHIQFI 219
             |.|.           ...|::::.:||.|||..:::.|  |.|.|  .:||..  ...||.:.|
Human   554 NDEFY-----------TKQDVIITALDNVEARRYVDSRCLANLRPL--LDSGTM--GTKGHTEVI 603

  Fly   220 RPGDTACFAC--APPLVVAENIDEKTLKREGVCAASLPTTMGIT---------AGFLVQNAL--K 271
            .|..|..:..  .||   .|.|...|||       |.|..:..|         :.|..:.:|  |
Human   604 VPHLTESYNSHRDPP---EEEIPFCTLK-------SFPAAIEHTIQWARDKFESSFSHKPSLFNK 658

  Fly   272 YLLNFGEVSDYL-----GYNALSDFFPKMTLKPNP----QCDDRNCLVRQKEFQAR--------- 318
            :...:....:.|     |::....|.....|...|    ||.:...|..:|.|..:         
Human   659 FWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFP 723

  Fly   319 ------------------PKPVLIEEKAVSEEPLHAT----------NEWGIELVAED------- 348
                              |.|:    |....||||.:          ..:.|....||       
Human   724 LDIRLKDGSLFWQSPKRPPSPI----KFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALL 784

  Fly   349 -------------------APESNTTPAETPVMGEGLRLAYEAPEKSSETSEETVS----AATAD 390
                               ..|:...|...|:..|..|.|....||:..::|.|.|    |..:.
Human   785 NILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSF 849

  Fly   391 E------------TSLEDLMAQMKSM 404
            |            |:..:|.|:|.|:
Human   850 EKDDDHNGHIDFITAASNLRAKMYSI 875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Uba5NP_572722.2 ThiF_MoeB_HesA_family 52..297 CDD:238386 67/275 (24%)
UBA6NP_060697.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Ube1 38..1046 CDD:273603 107/481 (22%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.