DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba5 and uba5

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001004790.1	Gene:	uba5 / 448010	XenbaseID:	XB-GENE-955661	Length:	399	Species:	Xenopus tropicalis

Alignment Length:	416	Identity:	260/416 - (62%)
Similarity:	307/416 - (73%)	Gaps:	29/416 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHAIDELQAIIADLKTELET----EPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQR 61
            |...|:||::.:::|:.||..    |....|        .|.:|:.|||||||||||||||||:|
Frog     1 MEKLIEELRSRVSELEEELHRVRNGEQVHEG--------HRAKINTMSAEVVDSNPYSRLMALKR 57

  Fly    62 MNIVKDYERIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFTPDQAGLS 126
            |.||:|||:||...||:|||||||||||:||||||||||:||||||||:||||||||.|.|||||
Frog    58 MGIVEDYEKIRTFTVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVEMANMNRLFFQPHQAGLS 122

  Fly   127 KVAAAAATLSFINPDVEIETHNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAI 191
            ||.||..||..|||||:.|.|||||||::||..|:|.||:||...|.||||||||||||||||||
Frog   123 KVEAAEHTLRNINPDVQFEVHNYNITTLDNFQHFMDRISKGGLKEGTPVDLVLSCVDNFEARMAI 187

  Fly   192 NAACNERNLNWFESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDEKTLKREGVCAASLPT 256
            |.||||....|.||||||||||||||.|:||:|||||||||||||.|||||||||||||||||||
Frog   188 NTACNELVQIWMESGVSENAVSGHIQLIKPGETACFACAPPLVVAANIDEKTLKREGVCAASLPT 252

  Fly   257 TMGITAGFLVQNALKYLLNFGEVSDYLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQ----A 317
            |||:.||.||||.||||||||.||.||||||:.||||.|.:||||||.|:.|..:|:||:    |
Frog   253 TMGVVAGMLVQNVLKYLLNFGTVSFYLGYNAMQDFFPTMAMKPNPQCGDKYCRKQQEEFKLKEAA 317

  Fly   318 RPK--PVLIEEKAVSEEPLHATNEWGIELVAEDAPES-NTTPAETPVMGEGLRLAYEAPEKSSET 379
            |||  |::::|    ||.:|..|:||||||:|.:.|. .......|.:.||:::||..|     .
Frog   318 RPKQEPIVVKE----EEIVHEDNDWGIELVSEVSEEELKAASGPVPELPEGIKVAYTVP-----I 373

  Fly   380 SEETVSAATAD-ETSLEDLMAQMKSM 404
            :|.|......| |.||::||||||::
Frog   374 TEPTSGFIVEDSEQSLDELMAQMKNL 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	193/244 (79%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	200/256 (78%)
uba5	NP_001004790.1	ThiF_MoeB_HesA_family	48..293	CDD:238386	193/244 (79%)
uba5	NP_001004790.1	UFM1-interacting sequence (UIS). /evidence=ECO:0000250\|UniProtKB:Q9GZZ9	331..343		6/11 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	403	1.000	Domainoid score	I715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11738
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1422
OMA	1	1.010	-	-		QHG54107
OrthoDB	1	1.010	-	-		D1092362at2759
OrthoFinder	1	1.000	-	-		FOG0006244
OrthoInspector	1	1.000	-	-		oto103460
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2874
SonicParanoid	1	1.000	-	-		X4526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110