DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba5 and uba1

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_998227.1	Gene:	uba1 / 406335	ZFINID:	ZDB-GENE-040426-2009	Length:	1058	Species:	Danio rerio

Alignment Length:	478	Identity:	101/478 - (21%)
Similarity:	160/478 - (33%)	Gaps:	172/478 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TELETEPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGV 81
            ||.|..|::.            |.|...|  |..:....|:|.||              ..:||.
Zfish   441 TEEECAPRNC------------RYDGQIA--VFGSKLQELLAKQR--------------YFLVGA 477

  Fly    82 GGVGSVT----ADMLTRCGIGKLILFDYDKVELANMNRLF-FTPDQAGLSKVAAAAATLSFINPD 141
            |.:|...    |.|....|.|::|:.|.|.:|.:|:||.| |.|......|...|||.:..:||.
Zfish   478 GAIGCELLKNFAMMGLASGEGEVIVTDMDTIEKSNLNRQFLFRPWDVTKMKSETAAAAVKQMNPS 542

  Fly   142 VEIETHNYNI---TTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNERNLNWF 203
            |.|..|...:   |.....|.|.:.:           |.|.:.:||.:|||.::..|........
Zfish   543 VRITGHQNRVGPDTEKVYDDDFFECL-----------DGVANALDNVDARMYMDRRCVYYRKPLL 596

  Fly   204 ESGVSENAVSGHIQFIRPGDTACFACA--PPLVVAENIDEKTLKREGVCA-ASLPTTMGITAGFL 265
            |||..  ...|::|.:.|..|..::.:  ||        ||::.   :|. .:.|..:..|..:.
Zfish   597 ESGTL--GTKGNVQVVIPFITESYSSSQDPP--------EKSIP---ICTLKNFPNAIEHTLQWA 648

  Fly   266 -----------VQNALKYLLNFGEVSDYLGYNALSDFFPKMTLK-PNPQCDDRNCLVRQKEFQAR 318
                       .:|||:||.:              ..|.:.||| |.                |:
Zfish   649 RDEFEGLFKQPAENALQYLTD--------------SKFMERTLKLPG----------------AQ 683

  Fly   319 PKPVL--IEEKAVSEEPLH-------ATNEW------GIELVAEDAPESNTTPAETPVMGEGLR- 367
            |..|:  :.:..|::.|.:       |.|.|      .|..:..:.|....|.:..|......|
Zfish   684 PLEVVESVYKSLVTDRPRNWDDCVTWARNHWQCQYNNNIRQLLHNFPPDQLTSSGAPFWSGPKRC 748

  Fly   368 -------------------------LAYEAP---EKSSET----------------------SEE 382
                                     |:|..|   ::|:.|                      .:|
Zfish   749 PHPLEFSTNNDLHMDYILAAANLYALSYGLPSCNDRSALTKLLQDIKVPEFTPKSGVKIHVSDQE 813

  Fly   383 TVSA-ATADETSLEDLMAQMKSM 404
            ..|| |:.|::.||:|...:.|:
Zfish   814 LQSANASVDDSRLEELKTLLPSL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	62/266 (23%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	66/279 (24%)
uba1	NP_998227.1	Ube1	49..1055	CDD:273603	101/478 (21%)
		Ube1_repeat1	54..436	CDD:238768
		E1_4HB	303..366	CDD:292809
		Ube1_repeat2	471..1011	CDD:238767	90/434 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810