DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba5 and Uba4

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	91/354 - (25%)
Similarity:	144/354 - (40%)	Gaps:	74/354 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IDELQAIIADLKTELETEPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYE 69
            :|.|.:.....:.|:......|..||.:::|..|.|.|          |||.:.|.... |:...
  Fly    34 LDSLFSFATRPEQEVVGNDLESPDVAVHTKLTNDDIAR----------YSRQLILPDFG-VQGQL 87

  Fly    70 RIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNR-LFFTPDQAGLSKVAAAAA 133
            :::..:|.|||:||:|...|..|...|.|.|.|.|||:||.:|.:| :..:.|:.|:||..:|..
  Fly    88 KLKNSSVLIVGLGGLGCPAAQYLAAAGCGHLGLVDYDEVERSNFHRQILHSEDRCGMSKAESARI 152

  Fly   134 TLSFINPDVEIETHNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNER 198
            .|..:||..||:.|:          |.|...:....|.|  .|:||.|.||...|..::.||
  Fly   153 ALLELNPHCEIQCHS----------RMLYPHNAMHIIRG--YDVVLDCTDNVPTRYLLSDAC--- 202

  Fly   199 NLNWFESGVSENA--VSGHIQFIRPGDTACFAC----APPLVVAENIDEKTLKREGVCAASLPTT 257
             :...:..||.:|  :.|.:......:..|:.|    .||.....|..:     .||..|    .
  Fly   203 -VMLSKPLVSGSALKMDGQLTVYNYANGPCYRCIFPVPPPPEAVTNCGD-----GGVLGA----V 257

  Fly   258 MGITAGFLVQNALKYLLNFGEV--SDYLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQARP- 319
            .|.........|:|.::..|:|  ...|.::..|..|             ||..:|.|    ||
  Fly   258 TGTIGAMQALEAIKVIVGMGDVLAGRLLIFDGGSGVF-------------RNIRIRSK----RPN 305

  Fly   320 ------KPVLIEEKAVSEE---PLHATNE 339
                  :|::.|  .::.|   .:|||::
  Fly   306 CHMCSAQPLITE--LINYEMFCGMHATDK 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	69/253 (27%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	71/265 (27%)
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	87/332 (26%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	72/276 (26%)
		RHOD_ThiF	336..453	CDD:238784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446837
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840