DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba5 and Uba1

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001014102.1	Gene:	Uba1 / 314432	RGDID:	1359327	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	91/473 - (19%)
Similarity:	162/473 - (34%)	Gaps:	154/473 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LETEPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGG 83
            ||..|:....:..:..|.|            .|.|...:|:...::   .|::..:...:||.|.
  Rat   429 LECLPEDKEALTEDKCLPR------------QNRYDGQVAVFGSDL---QEKLGKQKYFLVGAGA 478

  Fly    84 VGSVTADMLTRCGI-----GKLILFDYDKVELANMNRLF-FTPDQAGLSKVAAAAATLSFINPDV 142
            :|..........|:     |::::.|.|.:|.:|:||.| |.|......|...|||.:..:||.:
  Rat   479 IGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYI 543

  Fly   143 EIETHNYNI----TTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNERNLNWF 203
            ::.:|...:    ..:.:.|.|            |.:|.|.:.:||.:|||.::..|........
  Rat   544 QVTSHQNRVGPDTERIYDDDFF------------QNLDGVANALDNVDARMYMDRRCVYYRKPLL 596

  Fly   204 ESGVSENAVSGHIQFIRPGDTACFACA--PPLVVAENIDEKTLKREGVCA-ASLPTTMGITAGFL 265
            |||..  ...|::|.:.|..|..::.:  ||        ||::.   :|. .:.|
  Rat   597 ESGTL--GTKGNVQVVIPFLTESYSSSQDPP--------EKSIP---ICTLKNFP---------- 638

  Fly   266 VQNALKYLLNFGEVSDYLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQAR--------PKPV 322
              ||:::.|.:..           |.|..:..:|   .::.|..:...:|..|        |..|
  Rat   639 --NAIEHTLQWAR-----------DEFEGLFKQP---AENVNQYLTDSKFVERTLRLAGTQPLEV 687

  Fly   323 L--IEEKAVSEEP-------LHATNEW------GIELVAEDAPESNTTPAETPV----------- 361
            |  ::...|.:.|       ..|.:.|      .|..:..:.|....|.:..|.
  Rat   688 LEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPL 752

  Fly   362 ---MGEGLRLAY------------------------------EAPE-------KSSETSEETVSA 386
               :...|.|.|                              :.||       |...:.:|..||
  Rat   753 TFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSA 817

  Fly   387 -ATADETSLEDLMAQMKS 403
             |:.|::.||:|.|.:.|
  Rat   818 NASVDDSRLEELKATLPS 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	54/257 (21%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	56/269 (21%)
Uba1	NP_001014102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Ube1	49..1055	CDD:273603	91/473 (19%)
		2 approximate repeats. /evidence=ECO:0000255	63..611		47/210 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810