Protein Alignment Uba5 and MOCS3

DIOPT Version :10

• Sequence 1: NP_572722.2
• Gene: Uba5 / 32094
• FlyBaseID: FBgn0030305
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_055299.1
• Gene: MOCS3 / 27304
• HGNCID: 15765
• Length: 460
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 96/372 - (25%)
• Similarity: 138/372 - (37%)
• Gaps: 93/372 - (25%)

  Fly     8 LQAIIADLKTEL-------------ETEPKSS-----GGVASNSRLARDRIDRMSAEVVDSNPYS 54
            |||.:|..:.||             |.||:..     ..:...:.|:||.|.|          ||
Human    10 LQAEVAQREEELNSLKQKLASALLAEQEPQPERLVPVSPLPPKAALSRDEILR----------YS 64

  Fly    55 RLMALQRMNIVKDYERIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFT 119
            |.:.|..:. |....|:....|.|||.||:|...|..|...|:|:|.|.|||.||::|:.|....
Human    65 RQLVLPELG-VHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLH 128

  Fly   120 PDQ-AGLSKVAAAAATLSFINPDVEIETHNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVD 183
            .:. ||.:|..:|||:|..:|..||...:...:|..    ..||.:.:        .|:|..|.|
Human   129 GEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPA----TALDLVRR--------YDVVADCSD 181

  Fly   184 NFEARMAINAAC--NERNLNWFESGVSENAV--SGHIQFIRPGDTACFAC----APPLVVAENID 240
            |...|..:|.||  ..|.|      ||.:|:  .|.|.........|:.|    .||.....|
Human   182 NVPTRYLVNDACVLAGRPL------VSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTN-- 238

  Fly   241 EKTLKREGVCAASLPTTMGITAGFL----VQNALKYLLNFGEVSDYLG----YNALSDFFPKMTL 297
                     ||..  ..:|:..|.|    ....||.....|  ..|.|    ::||...|..:.|
Human   239 ---------CADG--GVLGVVTGVLGCLQALEVLKIAAGLG--PSYSGSLLLFDALRGHFRSIRL 290

  Fly   298 KPN----PQCDDRNCLVRQKEFQA----------RPKPVLIEEKAVS 330
            :..    ..|.:|..:....:::|          |...:|..|:.||
Human   291 RSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVS 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	73/261 (28%)
MOCS3	NP_055299.1	ThiF_MoeB_HesA_family	62..285	CDD:238386	73/266 (27%)
		Interaction with NFS1. /evidence=ECO:0000269|PubMed:23593335	158..238		23/97 (24%)
		RHOD_ThiF	327..460	CDD:238784	4/11 (36%)