DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba5 and ula-1

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001348740.1	Gene:	ula-1 / 266650	WormBaseID:	WBGene00006735	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	71/378 - (18%)
Similarity:	124/378 - (32%)	Gaps:	112/378 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 AVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFT-PDQAGLSKVAAAAATLSFI 138
            :..::|...:.:.....|...|:....:.|..|||.|::.:.||. .|..|.|:..|....|:.:
Worm    29 SACVLGSDSLATEILKSLVLAGVQSFYVVDDAKVEQADIGQNFFLHADDIGRSRAEATLEKLTEL 93

  Fly   139 NP-----------------DVEIETHNYNITTVENFDRFLDT----ISQGGRIAGQPVDLVLSCV 182
            ||                 |||..| .:::....|.:..:||    :....|:.       ..|:
Worm    94 NPSVSGSASSQPPTALAMEDVEKLT-TFSVVVAANQNEEIDTTFAKVLYNIRVP-------FICI 150

  Fly   183 DNFEARMAINAACNERNLNWFESGVSENAVSGHIQFIRPGD---TACFACAPPLVVAENIDEKTL 244
            ..|.....|.....|..:           .:.|.:..|| |   .|.|:....::...|:||.||
Worm   151 KTFGLIGTIRICIKEHTI-----------ANSHEENPRP-DLRLDAPFSKLIEMINETNLDEMTL 203

  Fly   245 KREGVCAASLPTTMGITAGFLVQNALKYLLNFGEVSDYLGYNALSDFFPKMTLKPNPQCDDRNCL 309
            ::                   :::....||:|..:..:.......:.||..|
Worm   204 EQ-------------------LRHTPYILLHFKALEVFRKQRNDPEAFPSTT------------- 236

  Fly   310 VRQKEFQARPKPVLIEEKAVSEEPLHATNEWGIELVAE--------------------DAPESNT 354
            ..:||.||    :|:..:..|||.....:|...|..|.                    .:|:.:|
Worm   237 AERKELQA----ILMSFRRSSEESGTKDSENFDEAKAAVIRAFQRTTFQIGSSVKSILSSPQCST 297

  Fly   355 TPAETPVMGEGLR-----------LAYEAPEKSSETSEETVSAATADETSLED 396
            :.....::.|.||           |....|:.:|::|..|..|....|.:|.|
Worm   298 STRPFWLICEALRRFVTENNNLLPLRGTLPDMTSDSSRYTRLATLFHEKALSD 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	45/246 (18%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	46/259 (18%)
ula-1	NP_001348740.1	APPBP1_RUB	8..541	CDD:238770	71/378 (19%)
ula-1	NP_001348740.1	E1_enzyme_family	<443..541	CDD:304554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900