DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba5 and uba-2

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001293154.1	Gene:	uba-2 / 24104970	WormBaseID:	WBGene00006700	Length:	582	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	84/380 - (22%)
Similarity:	139/380 - (36%)	Gaps:	105/380 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 YERIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLF-FTPDQAGLSKVAAA 131
            :|:|....:.::|.||:|......|...|..|:.:.|.|.::::|:||.| |..:....||.|.|
Worm     8 HEKIVQSKILVIGAGGIGCELLKNLAVTGFRKVHVIDLDTIDISNLNRQFLFRKEHVSSSKAATA 72

  Fly   132 AATLSFINPDVEIE-THNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAAC 195
            ...:....|.:|:. .|:.......|.:.|            |..|:||:.:||..||..:|..|
Worm    73 TQVVKQFCPQIELTFDHDSIFEKKYNMEFF------------QAYDIVLNALDNRAARNYVNRMC 125

  Fly   196 NERNLNWFESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDEKTLKREGVCAASLPTTMGI 260
            :..|....:||  .....|.:..|..|.|.|:.|         :|:             |.....
Worm   126 HAANRPLIDSG--SGGYFGQVSVIMRGKTECYEC---------VDK-------------PVQQTT 166

  Fly   261 TAGFLVQNA----------LKYLLN--FGEVSDYLGYNALSDFFPKM-TLKPNPQCDDRNCLVRQ 312
            ..|..::|.          .|::.|  ||||      :...|..|.| .:.|    |:...:..:
Worm   167 YPGCTIRNTPSEHIHCTVWAKHVFNQLFGEV------DIDDDVSPDMDAVDP----DNTEAVTTE 221

  Fly   313 KEFQARPKPVLIEEKAVSEEPLH-ATNEWGIELVAEDAPE-----------------------SN 353
            |           |::|:.|||.. .|.:|. |.|..||.:                       ..
Worm   222 K-----------EKEAMKEEPAPVGTRQWA-ESVDYDAAKVFDKLFLHDIEYLCKMEHLWKQRKR 274

  Fly   354 TTPAE----TPVMGEGLRLAYEAPEKSSETSEETVS-AATADETSLEDLMAQMKS 403
            .:|.|    :...||...|   ...:..:||..|:| .|....|.:::|:.|:::
Worm   275 PSPLEFHTASSTGGEPQSL---CDAQRDDTSIWTLSTCAKVFSTCIQELLEQIRA 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	57/243 (23%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	59/256 (23%)
uba-2	NP_001293154.1	ThiF	9..>172	CDD:279270	47/198 (24%)
		E1_enzyme_family	15..434	CDD:304554	82/373 (22%)
		UAE_UbL	442..526	CDD:291402
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810