DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba5 and uba-5

DIOPT Version :9

Sequence 1:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001370592.1	Gene:	uba-5 / 171968	WormBaseID:	WBGene00020184	Length:	419	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	240/383 - (62%)
Similarity:	290/383 - (75%)	Gaps:	14/383 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGGVGS 86
            :|||....       |.:|:::|||||||||||||||||||.||.:|||||.|.||:||||||||
Worm    40 QPKSPAPY-------RQKIEKLSAEVVDSNPYSRLMALQRMGIVNEYERIREKTVAVVGVGGVGS 97

  Fly    87 VTADMLTRCGIGKLILFDYDKVELANMNRLFFTPDQAGLSKVAAAAATLSFINPDVEIETHNYNI 151
            |.|:|||||||||||||||||||:|||||||:.|:|||||||.||..||..:||||:||.||:||
Worm    98 VVAEMLTRCGIGKLILFDYDKVEIANMNRLFYQPNQAGLSKVEAARDTLIHVNPDVQIEVHNFNI 162

  Fly   152 TTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNERNLNWFESGVSENAVSGHI 216
            ||::|||.|::.|.:|....|: :|||||||||||||||:|.||||.|..|.|||||||||||||
Worm   163 TTMDNFDTFVNRIRKGSLTDGK-IDLVLSCVDNFEARMAVNMACNEENQIWMESGVSENAVSGHI 226

  Fly   217 QFIRPGDTACFACAPPLVVAENIDEKTLKREGVCAASLPTTMGITAGFLVQNALKYLLNFGEVSD 281
            |:|.||.||||||.||||||..|||:||||:|||||||||||.:.|||||.|.|||||||||||.
Worm   227 QYIEPGKTACFACVPPLVVASGIDERTLKRDGVCAASLPTTMAVVAGFLVMNTLKYLLNFGEVSQ 291

  Fly   282 YLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQAR--PKPVLIEEKAVSEEP-LHATNEWGIE 343
            |:||||||||||:.::||||.|||.:||.||||::.:  .:||.:|.:...||. :|..||||||
Worm   292 YVGYNALSDFFPRDSIKPNPYCDDSHCLQRQKEYEEKVANQPVDLEVEVPEEETVVHEDNEWGIE 356

  Fly   344 LVAEDAPESNTTPAETPVMGEGLRLAYEAPEKSSETSEETVSAATAD-ETSLEDLMAQ 400
            ||.|..|.:..:.:..  .|.||:.|||..::.::|......|||.| ..|::|.:.:
Worm   357 LVNESEPSAEQSSSLN--AGTGLKFAYEPIKRDAQTELSPAQAATHDFMKSIKDKLVE 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	185/244 (76%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	192/256 (75%)
uba-5	NP_001370592.1	ThiF_MoeB_HesA_family	63..307	CDD:238386	185/244 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167382
Domainoid	1	1.000	384	1.000	Domainoid score	I430
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11738
Inparanoid	1	1.050	467	1.000	Inparanoid score	I848
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54107
OrthoDB	1	1.010	-	-		D1092362at2759
OrthoFinder	1	1.000	-	-		FOG0006244
OrthoInspector	1	1.000	-	-		oto17747
orthoMCL	1	0.900	-	-		OOG6_104369
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2874
SonicParanoid	1	1.000	-	-		X4526
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840