Protein Alignment Uba5 and SAE1

DIOPT Version :10

• Sequence 1: NP_572722.2
• Gene: Uba5 / 32094
• FlyBaseID: FBgn0030305
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_005491.1
• Gene: SAE1 / 10055
• HGNCID: 30660
• Length: 346
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 69/398 - (17%)
• Similarity: 121/398 - (30%)
• Gaps: 174/398 - (43%)

  Fly    22 EPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGGVGS 86
            |.:.:||..|....|:               |.|.:.|..:...|   |:|...|.:||:.|:|:
Human     3 EKEEAGGGISEEEAAQ---------------YDRQIRLWGLEAQK---RLRASRVLLVGLKGLGA 49

  Fly    87 VTADMLTRCGIGKLILFDYDKVELANMNRLFFTPD-----------QAGLSKVAAAAATLSFINP 140
            ..|..|...|:..|.:.|:::|          ||:           ..|.::..|:......:||
Human    50 EIAKNLILAGVKGLTMLDHEQV----------TPEDPGAQFLIRTGSVGRNRAEASLERAQNLNP 104

  Fly   141 --DVEIETHNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNERNLNWF 203
              ||:::|.:
Human   105 MVDVKVDTED------------------------------------------------------- 114

  Fly   204 ESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDEKTLKREGVCAASLPTTMGITAGFLVQN 268
               :.:...|...||    |..|..|....|:        :|.:.:|.               :|
Human   115 ---IEKKPESFFTQF----DAVCLTCCSRDVI--------VKVDQICH---------------KN 149

  Fly   269 ALKYLLNFGEVSDYLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQARPKPVLIEEKAVSEEP 333
            ::|:..  |:|..|.||...:                    :.:.||        :|||
Human   150 SIKFFT--GDVFGYHGYTFAN--------------------LGEHEF--------VEEK------ 178

  Fly   334 LHATNEWGIELVAEDAPE--------SNTTPAETPVMGEGLRLAYEAPEKSSETSEETVSAATAD 390
               |....:....||.|:        |.||..:..|:...::.|.|. :.|||.::..:...|:|
Human   179 ---TKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEV-DWSSEKAKAALKRTTSD 239

  Fly   391 ETSLEDLM 398
            ...|:.|:
Human   240 YFLLQVLL 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	42/257 (16%)
SAE1	NP_005491.1	Aos1_SUMO	16..341	CDD:238769	65/385 (17%)