DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	570	Identity:	151/570 - (26%)
Similarity:	265/570 - (46%)	Gaps:	98/570 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SVFYFLLLPTLVLWYIYWRLSRAHLYRLAGRLPGPRGLPIVGHLFDVIGPASSVFRTVIRK---S 76
            ::.:.|.|..:....:|  |.|..|.|.....|||....::||...:..........:::|   :
Mouse    17 ALVFCLALVLMQAMKLY--LRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKKHPCA 79

  Fly    77 APFEHIAKMWIGP-KLVVFIYDPRDVELLLSSHVYIDKASEY--KFFKPWLGDGLLISTGQKWRS 138
            .|      .|:|| :...:||||...::.||.   .|...:|  :...|.:|.|||...|.:|..
Mouse    80 FP------CWVGPFQAFFYIYDPDYAKIFLSR---TDPKMQYLHQLLTPCIGRGLLNLDGPRWFQ 135

  Fly   139 HRKLIAPTFHLNVLKSFIELFNENSRNVV---RKLRAEDGRTFDCHDYMSEATVEILLETAMGVS 200
            ||.|:.|.||.::||..::....:.:.::   .|:......|.:..::::..|::|:::.|.|..
Mouse   136 HRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQE 200

  Fly   201 KKTQDKSGFE-YAMAVMRMCDILHARHRSIFLRNEFVFTLT---RYYKEQGRLLNIIHGLTTKVI 261
            ...|....:| |..|...:.:|:.:|..:.:..::.:|.|:   ..::|.|:   :||..|.|:|
Mouse   201 TNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGK---VIHQYTEKII 262

  Fly   262 RSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPVAGLSYG 326
            :.:|..
Mouse   263 QDRKKI----------------------------------------------------------- 268

  Fly   327 QSAGLKDDLDVEDNDIGEKKRLAFLDLMLES-AQNGALITDTEIKEQVDTIMFEGHDTTAAGSSF 390
                ||:.:..:|....:    .|||::|.: |::....:|.:::.:|:|.|:.|||.:||..|:
Mouse   269 ----LKNQVKQDDTQTSQ----IFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDASAASISW 325

  Fly   391 FLSLMGIHQDIQDRVLAELDSIFGDSQRPATFQDTLEMKYLERCLMETLRMYPPVPLIARELQED 455
            .|..:.::.:.|||...|:.||.||.. ..|::...||.|...|:.||||:.||||.|:|||.:.
Mouse   326 LLYCLALNPEHQDRCRTEIRSILGDGS-SITWEQLDEMSYTTMCIKETLRLIPPVPSISRELSKP 389

  Fly   456 LKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFVPFSAGPRSCV 520
            |.|..| :.:|.|.||.::...||.||.|:.:|.||||..|..|....||..||:|||:|||:|:
Mouse   390 LTLPDG-HSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPFSSGPRNCI 453

  Fly   521 GRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQ 570
            |:::|||:||:.::.||.:::|..|||... ...:..:|:.:.|..:.|:
Mouse   454 GQQFAMLELKVAIALILLHFQVAPDLTRPP-AFSSHTVLRPKHGIYLHLK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	137/508 (27%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	143/533 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920